5UJC


Conserved Protein Domain Family
MMACHC

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pfam16690: MMACHC 
Methylmalonic aciduria and homocystinuria type C family
Statistics
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PSSM-Id: 465235
Aligned: 24 rows
Threshold Bit Score: 311.877
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UJC_A        31 KIGSYNEAVgeSSPFALPYDDSTMALLILSTPDMFDVAFRKWV----------------------VQkTMDFGSfdevce 88  Caenorhabditis ...
EKC18165      20 LIGWYNEHV--QEVFRLSYPADTLGLLVISTPDMFERAFIPFV----------------------KEqEECDGI------ 69 
EFX90307      26 KVGWYNERV--KSGYQLEHHEDTLCFVVISSPSFFEKGFIPFV----------------------RNsTESNN------- 74 
XP_002404566  30 KIQWYNDRV--PGAFKFQRHPDTLCFVSLSTPSTFEKAFLPFV----------------------LN-DRNLTL------ 78 
XP_002115419  27 KISWYNDQV--DDHFKLKCNQNALAFIIISLPQMFDKTFKTFImkkynidnfpledkaewneeekEEfSYNQNV------ 98 
EDO39337       2 QIGWYNNQVt-HKQFQFPFDPDTLAFVIISTPEMFEKGFKPFI----------------------TD-ADCLGS------ 51 
3_pfamImport   8 KVGWYNDTV--IPSFKLPYDNDTLCAVILTIPSFFENAFLPNL----------------------STfFSQSDS------ 57 
4_pfamImport   8 QVAWYNELL--SPAFHLP-PGPTLAFQVLSTPATFDQALKTLL----------------------R--AHLQLL------ 54 
XP_011405503  31 KIQWYNDKV--SDSFKLPYNGDTLAVLIISAPKMFEELLKPFIlggkykre------gfnalkdeENeRKEEGG------ 96 
XP_009009623  27 KIGWYNDEV--HKSFHLEYDYDTLAFSLVSLPKMFDILFCPFL----------------------EQ-WDGKGG------ 75 
5UJC_A        89 mvSSPIQSFLEDRLEIMSEKLRKVEenFEILHDYSMTP-QRRPKILMQTCGHVAGAAFYYQ--------PCHFQEDGVtw 159 Caenorhabditis ...
EKC18165      70 --RDPIDQCVAYYFNKVKEDFPEYE--VESIHDYEMHH-SRRPKILVQTVGHVSGAVYYYQks----dvTDQPWPTDK-- 138
EFX90307      75 --QDYLDQAISSCLKTAIQSISGYD--ISILHDYEMRPgTRRPKVLVQTAGHVSGAVYFYQkt----dvINPPWLTDQ-- 144
XP_002404566  79 --KDPFDQCMTACFARAIQAFPGES--VELLQDFELHP-NRRPKVIMQTAGHVSGAVHYYGcn----dmEITESPPNK-- 147
XP_002115419  99 --YDPLDQCMLDYFQKIRNHFPDHQ--LHIIRDFEMDA-SHRPKVLVQTAGHVAGAVRYYQrc----dvHDDPWDESQ-- 167
EDO39337      52 --RDPIDECMAAFFLKVKQAFPCHE--IDAIHDFELHP-NRRPKVLVQTAAHAAGAAYFYQrk----diTDDPWPPTQ-- 120
3_pfamImport  58 --KDPIDKCIAHHINSALSNLDING--VEVMYDYEILP-NRRPKVLVQTAAHVSGAAFYYQrhhcnskcLNDHWDKNR-- 130
4_pfamImport  55 --TRPVDQCVAYHHH-VKESPPELQ--VEVVADCEVHP-NQSPEILAQTAAQVVEAAYYqd-------vETDPS-GTK-- 118
XP_011405503  97 --SDPLDQCFRDVFNKLQTHFSQYK--TTFIQDYELHH-NRRPKILLQTAGHVSGSAYYYQrg----dvPRAPWGEDK-- 165
XP_009009623  76 --NDALDECMRFYLNKLKSNF--TD--VELIHDFEFHH-SKRPKVLVQTAGHVSGGVFYFQrkd---ikHSDPWPENR-- 143
5UJC_A       160 ppagrmgpnlKFIGLSLHPIYGGHFAFRSVLIFPNVKI-PE-FCEKEPRPILTASEDVRTALEKFNYNWKDSGFRDFG-- 235 Caenorhabditis ...
EKC18165     139 ----------KICGVCYHPVYGGWFGLRGVLIFKDVLC-PP-LQQPLPKDVIPSQEKRVELLNKFNFHWQDWTFRDLL-- 204
EFX90307     145 ----------PIYGVCLHPSYIGWFALRAVIIFQKVLV-PD-LVYKPPKDILVDETKKIELLNRYNNSWQDWSFRDIM-- 210
XP_002404566 148 ----------KLLGVCIHPKYGGWFAFRGVFIFSDILV-PD-LEQRQPADVVQREDVRRDLLRLFNFSWQNGLYRDVI-- 213
XP_002115419 168 ----------RIYGTCVHPKYGGWFALRGVIIFEDVN--ANkLAQVDPPDMIKTDQDRIRLLNLYNFHWRDWSFRDVLp- 234
EDO39337     121 ----------RICGVCVHPKYGGWFAIRGVLIFKTFKY-PD-LPRKQPMDVVVGDEKRIELLEKFNFHWEDWSFRDVV-- 186
3_pfamImport 131 ----------RIYGVCIHPKYGGWFAIRAVLVFKDMKD-PD-LQIQPPTDCVKSRNDRIDLLERFNGNWKDWTYRDII-- 196
4_pfamImport 119 ----------HILGVCVHPQRGGWFAIQEVVLLPEKEV-PD-LPPREPRDCVPTRADLAALLEGFNFHWCDWTYQDTV-- 184
XP_011405503 166 ----------PIYGVSVHPRYGGWFAFRGVLIFEDIRVkGEeLEYKDPIDCVSKREKRIELLEEFNYHWEEWRYRDILdg 235
XP_009009623 144 ----------KICGVCLHPKYGGWFGLRGILIFKNVKV-PN-LMKKE-LECFLSNEQIISLLDKFNNSWRDGTFRDVI-- 208
5UJC_A       236 -NPTRRYSTTQMEFFGRPVAERWEVL 260 Caenorhabditis elegans
EKC18165     205 -PVRQRYSQEQIMYFSTKPKDRPELI 229
EFX90307     211 -EPTERYSELQQKYLSTRPSERSHLI 235
XP_002404566 214 -DVDERYSARQQEYFRTVPSQRWELI 238
XP_002115419 235 -GVVARYSDEQKTFFSTPPSQRPQIL 259
EDO39337     187 -PSERKYSDQQIKYFSTLPVNRKDLL 211
3_pfamImport 197 -PVVEKYSELQKLYFITAPKERKH-- 219
4_pfamImport 185 -TPQEHYSE-QRAYFSTPHSQQLALL 208
XP_011405503 236 gDVEDRYSEEQKEYFGTLPKDRHKLV 261
XP_009009623 209 -EPLERYSTLQQKYFNVTPDERLELI 233
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