Conserved Protein Domain Family
Taxilin

?
pfam09728: Taxilin 
Myosin-like coiled-coil protein
Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.
Statistics
?
PSSM-Id: 462861
Aligned: 52 rows
Threshold Bit Score: 131.999
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EEN55084                        6 QTIKQTMq-TLNAMDNPDEKLGAIVKRYAELLGDHRSLQREFKAGQRMQAQVMREKEKLQAEHSKALLARSKLESL---C 81  
XP_004994135                   35 KEFRQIMqsPATGLND---REKAAVQRYTALKQENGSLKKQVLDLSTQLQQVQAENAVLEHKVAQ-------LNGL---S 101 
A0D4Z8                         32 KIARQSKi-SKSQLDSLEDK-TALITRLKKIINESKTAHKDALLSAKKFEIATQEKEKVFNENSKLKNQIKTLEGF---R 106  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00047689A  49 KAYTDLKe-FISANPDDANKIQ---EKFEKILKDIKQAAKDYAINKKLYETLIANFKKTKDENAQCIKSKDNYEKL---H 121 
EFA75417                       87 KSMKDLSs-SLATLKE-DEKVKLLLSKYQQNLTERFKYDKKLAQNEEAMSVLNKDNGRLAAELTKSNVVKVRLETL---F 161 
A0D273                         24 KAEESYKe-LIKNLNE-DLSIEQLKQLGNQFLEFSLVLQQDEYIQRKRAKEETQEKEQLL--HKEYPQLQDKLIKLkqnC 99   Paramecium tetraurelia...
XP_006696924                   85 KANRELQn-QTAKMMD-MQKIEFLTKRCSDLFMEMKRHERESIKNKKRTDQLQKDKDNSRQELNKTVSLKEKLEKL---C 159 
EFW99877                      103 KANRELHs-QTAKMDS-LQKIDHLSKRCTDLLHEMKRLERESQKNKKKNDQLQKERDQSRSDLSKTIGLKEKLEKL---C 177 
EGX89651                       70 RATRDLVq-QISKMDD-SQKIDHLTKRSSELLADMRRLEKENQKNRKRGDILQKERDINRTELSKTVGLKEKLEKL---C 144 
XP_013960918                   70 RANRDLLq-QVSKMDD-MQKIEHLMKRSSELLADMRRLERENQKNKKRGDALQKERDASRTELSKTVGLKEKLEKL---C 144 
EEN55084                       82 RELQRHNKAIK---EESQRKMKEEEEKRREISSKFQTTLGEISTQMDD-NRDRSLK-MKEENME-----LCGKLKSLVEQ 151 
XP_004994135                  102 RRLAEQRTVIE---KQAEAMVKQEEAKRAELTQKFQASLADISARVEE-SSKEQKQ-RDEYHQA-----MQAKIDAFVKQ 171 
A0D4Z8                        107 NTQTNQLNEYQ---EKYSKVVDEEKQKKTELVEGFQQEIKDISTKMEE-VSNAKHK-SQAENEA-----LKEKMKEIQEH 176  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00047689A 122 KALTAQYQEQI---NTNKELQEKEKQKRTELAEQFQQRIKDIQSSVEE-KSRDRIQ-KEKENEI-----LKEKLKEITAQ 191 
EFA75417                      162 KEVQKRNDEVM---EYSKKTAVEEDQKRRDLSDKFNATLKDVSSKLND-FNDQNER-QAKYIEE-----LQDRIKSFEEI 231 
A0D273                        100 QEIDFNAKKIN---ETIKKLPEIEEANRKSMKDKFYEDVKDVKDKIQQ-EDTDAQK-FAEENLK-----IREEMQALIAQ 169  Paramecium tetraurelia...
XP_006696924                  160 RELQKENNKLKvlsHDSTDGMGKKQDADEFYVGRTRTKLLQMRKFGARlRGTSGIQaFCVEWMNikktkITHRFKSLIDQ 239 
EFW99877                      178 RELQKENNKLK---NENRTMKANEVSNLNSWDQKYATLLQKLDDLQDE-KDHPKKQ-VVDVELDe---lFRQRFKSLIEQ 249 
EGX89651                      145 RELQRDNNKMK---NENKELQAIQKRNTLSWDEKYATLLSKLEGYQED-KDIPRKQ-VVDMEMEe---lFRVRFKSFIEQ 216 
XP_013960918                  145 RELQRDNNKMK---NENKELQSTQKRNNTAWDEKFASLLSKLEGYQEE-KDTPKKQ-VVDMEMDe---lFRVRFKSFIEQ 216 
EEN55084                      152 YEKREEHVEKLIKQKDLERQLAEAKMQQATMmlaeEKEKFLTEKQVllKENYAHRERAEQMAIQEENMKMQLKLYTEKFE 231 
XP_004994135                  172 SEIREEQVAKLLKTKELEKQLAEAKLQQELEnkkvLQQQLAVQGKA----IDEYKASSQSLFDEFKKLSDQATAQQKELQ 247 
A0D4Z8                        177 VEKRDKIFDEELNKLDSQRKERETKI---------FEQINNISQSL--GTTDNSEDLLQKIKEEEALVEAHLNPHLQKAE 245  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00047689A 192 QQTTELIFSTQIKKKELEMQLQEAKLGQ-------EFELIKQQAQL----VSKFQEEIDKQKELDVKLEERLNVYLEQDK 260 
EFA75417                      232 SQKSNVKFDSVLKKTEAETSILILKL---------HQQIEMTNREN--AKAIKLKEELDRLTAENLIQKEKVKYYEDNFS 300 
A0D273                        170 YEQKEKDFWEKVKLNEEEQKNDTKKYMEQFEkmqgDAQKAMQEKQL-----------IQDAQKQLNDKKMKLQVYKGKQN 238  Paramecium tetraurelia...
XP_006696924                  240 YELRELHFHSQMRTKELEVQYNLARY---------EQQKKNYEAEY--ARSRQLNAQVQAFTQTEADLRHQLSVYVEKFK 308 
EFW99877                      250 YELRELHFHSLMRTKELEVQYNMARF---------EREKKRAEAEV--ALSRRLNEQVQTFSRTESELRNQLNLYVEKFK 318 
EGX89651                      217 YELRELHFHSQMRTKEIELQYHLSRF---------DRDKKATEAEL--AKMRQLQTQVQTLSRSETQLRTELNTYIDKLG 285 
XP_013960918                  217 YELRELHFHSLMRTKELEVQYHLSRH---------DREKKNAEAES--TKARHLQAQVHAFTKTETELRNQLNVYVDKFK 285 
EEN55084                      232 E---LHKTLNQSNEVFNKFKVEMDTMNKRMKKLEKESFQWRTKWEKSNVTLIAMAEEKQTRDKELIMLRTKCGKLENLCR 308 
XP_004994135                  248 KqrkAAGRMKQLEKEMGEWRNAFERLNKQCTAFKDAHDKQQELSGLLKDKLTSTVAERNKLLEEVASLKKLTRALSGSCK 327 
A0D4Z8                        246 E---FQQIIEKTNQQFNLYKNETEKLAQQCRSLEQKSQACQRKCEKSDIYIVDQAKEYQKLQVQYKQKQEQINSLLTLKS 322  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00047689A 261 K---FQDIMVESNSKFTNYKQAHDSLIDSQKKTESSINELKKKNEKTDFTLLDMVEKNVKLKEDLKKQLDQLSGLENLYA 337 
EFA75417                      301 Q---FQDIIQKSNEKFLSFKNDMEKVTKANRSLEKDNKQLHSKIEGTNKALINTMTE-------LTQQKKQNETLKNLCK 370 
A0D273                        239 E---FVETFEKSTSTFQNLTVEFLKLAFKVKEDEEKSILNQQRADKANLLTVEIAQKNADLKQQIENIEKEKDKLRAEIL 315  Paramecium tetraurelia...
XP_006696924                  309 Q---VEDTLNNSNDLFTTFRKEMEDMTKKTKRLEKENEQLKRKHEQVNGNILKMAEERNRNLSEIEELRKKLDKLNGIIK 385 
EFW99877                      319 Q-------------------KEMEEASSKTRKLEKDNDGMKRKHEAMSQNVVKMAEERAENARLLDLTKRQLEKLKSIVV 379 
EGX89651                      286 EacnVKSALDQRDDIFARQRKEMQDQAKKCKRLEKDNEALRRQKEATAANIIRMAEERQHWKNKMDIADRKTEKLMSIIQ 365 
XP_013960918                  286 Q---VEDTLNNSNDLFLSFRKEMEDMSKKGKRLEKENEALKRQKEATTANIIHMAEERQDWKRKIEAADKKNEKLMSIIQ 362 
EEN55084                      309 ALQNA 313 
XP_004994135                  328 EVQSQ 332 
A0D4Z8                        323 TLQSG 327  Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00047689A 338 ILEKQ 342 
EFA75417                      371 TLTTE 375 
A0D273                        316 ELNNQ 320  Paramecium tetraurelia
XP_006696924                  386 QMQQQ 390 
EFW99877                      380 MMQRQ 384 
EGX89651                      366 QMQQQ 370 
XP_013960918                  363 QMQQQ 367 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap