Conserved Protein Domain Family
DAZAP2

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pfam11029: DAZAP2 
DAZ associated protein 2 (DAZAP2)
DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organization and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats.
Statistics
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PSSM-Id: 402565
Aligned: 17 rows
Threshold Bit Score: 52.0411
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDS27834      29 YSPYPPGMVQ-HHQPYYATSAATWSVNPSTglpqatpmqyapappaaqhhhlpppppySAA--------AAGQPM----- 94 
EDV27812      28 QQHPPQQFAPqPGQVPYSAPPPAYNAAPGY----------------------------GPPqav---pqQQYYPNpn--- 73 
XP_011673611  53 YSAPPPGAGGyAGAP----PPYSAAGAPPpa-------------------------------------aQAGYPQ----- 86 
1_pfamImport   1 YPQAPPPYSA--------QPPMTYAGAPPTapqgy------------------gappqGYPagp---ppQAYPPG----- 46 
XP_005991475  35 YTDAPPSYSE-IYQPRYMHP--SSSTVPQL----------------------------SSTyp----anTMYIPMaqtvp 79 
EFN82050      61 qgpppPTYDQtLTHPMMYQPMYGQGYPGGY----------------------------LAGyptaygplQYYPPL----- 107
XP_002410303  11 pgdPPPPYTApYPAPYPAGGFPASHSLPS-----------------------------GGGywp---qpQTTQPMdha-- 56 
EKC43014      21 QFAYPQSQAQpw--------------------------------------------------------qPTAPPMyga-- 42 
ETN60456      49 yagYPQAMVP---QPFYSN---SWSMSPSGqpqfap-----------------ppppyGATpg-----aVAAIPAq---- 96 
Q0IFG8        49 YPPYPPGIVH--QQQFYPT---SWSVNPSApqaapmqyap---------hhlpppppyAAAtqq---aaVAAIPA----- 106 yellow fever mo...
EDS27834      95 ----HHHPAAMYQY--------PIATAAQLthqaq-----ppqvfQAQIYpv--------------qGAMYDAGARFGKA 143
EDV27812      74 ---mNAPPPMHYQQ--------PGQYQQFGt--------------ASVVMpi--------------qEGTFDAGARFDGR 114
XP_011673611  87 -------APVYYQP--------PQP--------------------QTVVV-----------------NGGYDAGARFNSR 114
1_pfamImport  47 ------PPPQSYPAgapaqymaPGPP-------------------QTVVV-----------------QGGFDAGARFDRN 84 
XP_005991475  80 vapvAPSMPMGYYS--------MGPSFPPG---------------STLVV-----------------GGAYDPGARFGAG 119
EFN82050     108 ------AAAAAYYP--------AAAMQPAPv-------------rPTIMV-----------------PNGFD-GTRFDGI 142
XP_002410303  57 -akmYPAPGQGYGQ--------APPAPPQYagasypqqpvvpqanQTTVYh---------------vPDAFDAGARFSAN 112
EKC43014      43 --psDPPPPYSYQA--------PPQQQPMPnyq----------aypTQVQnvqmytqgpmmasgglaTASFDSAARFDGI 102
ETN60456      97 ----TVHHPQMYQY--------QLAAAPPPqaqp-------pqmyQTQMYpv--------------qTAMFDSGARFGKS 143
Q0IFG8       107 ----QSVHPTMYQY--------PIATAPQPqppq--------vyhQTPMYqv--------------qGAMYDAGARFGKS 152 yellow fever mo...
EDS27834     144 ggGAATIPPPPPGIAPNAAQIAAMQGQQVVMTKKKNNFLHGGNGAGF 190
EDV27812     115 --SAPVVPPPPPGCVPNHAQLAASTGGAAVVRQNQSGFFTGGSSGVY 159
XP_011673611 115 --NPPSIPPPPPGCAPNAAQMASGTGQNVVMGQKPSNWVTGGSDGGY 159
1_pfamImport  85 --SPASIPPPPPGYAPTAGQLAAAQGNNVVMTQREESFFSGGSGGGY 129
XP_005991475 120 --ATANIPPPPPGCPPTMAQLAAMQNVNVVMTPRKGSYFTGGSDGGY 164
EFN82050     143 --SQPVLPPPPPGVAANAAQLAAMAGHSVALSQKKGSFLGGGTDGGY 187
XP_002410303 113 --TPASIPPPPPGVMPNAAQLAAMQGNQVVLGQKKSTFLSGTGGAGY 157
EKC43014     103 --SQPRIPPPPPGYMPTAAQQAVMQGRPVVATQQKAGWFSG-SGGGY 146
ETN60456     144 g-GTPTIPPPPPGMGPNAAQLASMQGQQVVVAKKKNNFLHGGNGSGY 189
Q0IFG8       153 g-GSASIPPPPPGIAPNAAQIAAMQGQQVVMTKKKNNFLHGGNGSGF 198 yellow fever mosquito
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