Conserved Protein Domain Family
Chisel
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pfam15355: Chisel 
Stretch-responsive small skeletal muscle X protein, Chisel
The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.
Links
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Statistics
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PSSM-Id: 405939
Aligned: 7 rows
Threshold Bit Score: 115.007
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001072253  1 MSKQPASNIRSIQANINIPMGAFRPGAGQPPRRKEIS------TEE-EPHvpmheSEEKNEEKKPIPGAVKLPGPVFNLS 73 
XP_014352888  1 MSKQPASNVRAIQANINIPMGAFLPGAGHPPKRKECS------VEA-DET-----ASAGTEEKKHLPGAVKLPGPSVNLS 68 
Q6GMK5        1 MSKQPSSNVKALQANLNIPMGALRPGAGHPVKRREDT------VET-EEV-----SPVTPEEKKPLPGAVKLPGPAVNLS 68  zebrafish
XP_003218882  1 MSKQPASNVRSIQANINIPMGALLPGAGQPPKRKEFT-------EP-DESl---pPSSEAEKKKTLPGAKKLPGPAVNLS 69 
XP_006911677  1 MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECT------PET-EEGv---pPTSD-EEKKPIPGAKKLPGPAVNLS 69 
XP_010724014  1 MSKQPASHVKAIQANINIPMGAFRPGAGHPHKRKEVT------PEEvEESv---pATEEEKDKKHLPGAIKLPGPAVNLS 71 
XP_004081248  1 -msKPSTNVKALQANLNIPMGALRPGAGLPVKRREETaaqmeeVPP-EQSc---pAAPTPEEKKPSPGALKLPGPAVNLS 75  Japanese medaka

NP_001072253 74 EIQNVKSELKFVPKAE 89 
XP_014352888 69 EIKSAKSELRFVPKAE 84 
Q6GMK5       69 ELQNVKSELRWVTKd- 83  zebrafish
XP_003218882 70 EIQNVKSELKFVPRAE 85 
XP_006911677 70 EIQNIKSELKYVPKAE 85 
XP_010724014 72 EIQNIKSELKFVPKAE 87 
XP_004081248 76 ELKNVKSELRWVTKd- 90  Japanese medaka
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