Conserved Protein Domain Family
7tmA_LPAR3_Edg7
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cd15343: 7tmA_LPAR3_Edg7 
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Links
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Statistics
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PSSM-Id: 320465
Aligned: 4 rows
Threshold Bit Score: 426.987
Created: 25-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human lysophosphatidic acid receptor 1 (LPAR1) in complex with antagonists
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                                                 #      #   #          ##  ##
Q9UBY5        31 VIVLCVGTFFCLFIFFSNSLVIAAVIKNRKfhfPFYYLLANLAAADFFAGIAYVFLMFNTgPVSKTLTvnrWFLRQGLLD 110 human
NP_001107182  31 IGVLCFGTFFCLFIFISNSLVIAAVVKNKRfhfPFYYLLANLAAADFFAGIAYVFLMFHTgPVSKTLTvnrWFLRQGLLD 110 chicken
AFQ98273      33 ILVQCVSSICCCFILVANAMIIAAVVTNKRfhyPFYYLLANLAASDFLAGIAYIYLMFNTgKISRDLTvqgYFFRQGLLD 112 zebrafish
XP_002931719  31 IIVLCFGACCCFFIFVSNLLVIAAVVINKRfhyPFYYLLANLAAADFFAGIAYVFLMFHTgPVSKTLTvnrWFLRQGLLD 110 western clawed ...

Feature 1          #                                                                          #  
Q9UBY5       111 SSLTASLTNLLVIAVERHMSIMRMrVHSNLtKKRVTLLILLVWAIAIFMGAVPtlgWNCLCNISACSslapiYSRSYLVF 190 human
NP_001107182 111 TSLTASLVNLLVIAVERHMSIMRMkIHSNLtKKRVTFLIISIWAIAIFMGAVPtlgWNCLCDISACSslapiYSRSYLVF 190 chicken
AFQ98273     113 ASLSASLTNLLVIALERYISIMNFkVHSNLtKRRVTLLIALVWGISIFMGAVPslgWNCICSLDLCSklapiFSRSYLIF 192 zebrafish
XP_002931719 111 TSMSASLANLLVIAVERHISIVRMrIHSNLtKRRVTFLIFLIWAIAIFMGAVPtlgWNCICNITTCSslapiYSRSYLTF 190 western clawed ...

Feature 1        #                                                            #  #  ##           
Q9UBY5       191 WTVSNLMAFLIMVVVYLRIYVYVKRKtnvlsphtsgsisRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGlncrqCG 270 human
NP_001107182 191 WSVLNLVVFFIMVVVYIRIYMYVQRKtnvlsshtsgsisRRRTPVKLMKTVMTLLGAFVVCWTPGLVVLLLDGlnctnCG 270 chicken
AFQ98273     193 WSVSNLVLFLIMVGVYVRIYVYVVKKtvvlkahtsgsinRKRTPIKLIKTVMTVLGAFVICWTPGLVVLLLDGlkcerCE 272 zebrafish
XP_002931719 191 WTVSNLAVFVIMLVVYLRIYMYVQRKtnvlsphttgsinRRRTPIKLMKTVMAVLGAFVICWTPGMVVLLLDGlnctkCG 270 western clawed ...

Feature 1            ## ##                         
Q9UBY5       271 VQHVKRWFLLLALLNSVVNPIIYSYKDedMYGTM 304 human
NP_001107182 271 IQNVKRWFLLLALLNSVMNPVIYSYKDdeMWGTM 304 chicken
AFQ98273     273 VLKFKRWLLLLAVLNSVMNPIIYSYRDeeMWNTI 306 zebrafish
XP_002931719 271 VQHVKRWFLLLALMNSIMNPIIYSYKDeeMWRTF 304 western clawed frog

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