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Family of unknown function (DUF5404) This is a family of unknown function found in Chordata. This domain is located downstream the N-terminal of Fip1 pfam05182. Family members such as Swiss:P70537 and Swiss:P70675 contain this domain. The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain. In vertebrates, Fip1 is the evolutionary precursor of eutherian Tsx, hence its location upstream from the Tsx gene. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",