Conserved Protein Domain Family
bHLH_TS_ATOH7
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cd19714: bHLH_TS_ATOH7 
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins
ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.
Links
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Statistics
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PSSM-Id: 381557
Aligned: 7 rows
Threshold Bit Score: 128.141
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #   # ### #    #                 ####                        
Q8N100        34 RLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERF 102 human
Q8AW52        22 KFESAMRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALNRILSDAGRH 90  zebrafish
O13126        27 RLEGSTKRRLAANARERRRMQGLNTAFDSLRKVVPQWGEDKKLSKYETLQMALSYIMALSRILTEAERY 95  African clawed frog
O57598        33 RMESAAKRRLAANARERRRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERY 101 chicken
XP_007897907  32 RVESGARRRLAANARERRRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERY 100 elephant shark
XP_014341838  33 RMESVARRRLAANARERRRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERY 101 coelacanth
XP_002124707 187 SICISRKRRQAANARERRRMEGLNKAFDSLRKVVPSISRRRKLSKYETLQMALSYIEELGRILQTTPSE 255 vase tunicate

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