6U42


Conserved Protein Domain Family
TPH

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pfam13868: TPH 
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Trichohyalin-plectin-homology domain
This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Statistics
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PSSM-Id: 464007
Aligned: 120 rows
Threshold Bit Score: 81.1184
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6U42_5A             140 MLEQKDPVKHMNQMMLYSKCVTIRDAQIEEKKQMLAEEEEEQRR-LDLMMEIERVKALEQYEARERQRVEERRKGAAVLS 218
XP_002061397         92 LRNNNQELRELSEHLKLAAISKDLSEHIGDFFKTRLQIEKSKAE-SQKQAELERLKFLDHVNKEQLKLKEQQIKLHDSLA 170
XP_002073380         51 LRTDCEELRQLAEHLRLAAITKDLCEQRAELQKSRLEAEKDKAK-SHQLAETERLRFLAEEQKKEVALKEQQKKLRDCLA 129
XP_002054568         94 LRSECEELRELAEQLRLASITKELEEHMVETKRNRELAKNAKAV-GLQRAEATRQQNLAMQEQEELRKKEQQEELRKTLA 172
XP_002000071         94 LRNDCEELRQLAEQLRLAAITKDLEEHMREVNRSRQLANHVKLQ-GLQRAEAERQQQLAMEQEKELRKKEQQEELRKTLI 172
XP_001992106        130 LHNNSLRLRDLHIEINRAKTTLSVVQKRNENMQTVGAERAERHReAQQVMEKVR----DEKLAEERALQMKSQVYSEQLV 205
XP_002059537        129 LHDNSQRLRDLKIEIDRAKTTLSVVKKRNENIRQHGAERADERKeALEHREQVR----EEKLAEQRALQEKAHNYSEQLV 204
WGS:AAPU:GI15335-PA 129 LQINSQRVRDLQIEIERAKTTLSVVSKRNENMRNKGKERVEERReALEDREQVR----KEKLAEQQALRDKTLAYSQQLV 204
XP_002031153        122 LHRNVENLRDLEMEVARAHTALAVKNKITNNIKQTVEDKQRERA-EALAEQRAVE---KQVLEEKQRRAQKAAVFRKDLM 197
WGS:AAPP:GF19498-PA 203 LHRNVNDLRRLKAEVDQAHTALVVRQTILENERQAAEIKQKERN-KALAEKRQLE---QEQRAEEMKKGLKASTFRRDLI 278
6U42_5A             219 EQIKERERERIRQEELRDQ-ERLQMLREIERLKEEEMQAQ-IEKKIQAKQLMEEVAAANSEQIKRKEGMKV-REKEEDLR 295
XP_002061397        171 AQMEQKQQRRKQESLQTLA-DRESRIAMQRQVEKEDSAKL-ALQERVKIQKLQEMDKYIEERKAHRVLQYK-EAEADLKK 247
XP_002073380        130 LQMEQTQQRRKKECVETVA-DRELRMALQLQIEEEDRALQ-YHLEQEKIRKRRDMNRLIEEKKTYKEFKNK-EEEVELKK 206
XP_002054568        173 KQIEEKRQQRQLRYVETLT-EREMRMAMQQQIEEEDRAEQ-LELNRLKLKKRDDMITFIKEQREYKELQRA-KSDENLSK 249
XP_002000071        173 SQVEERQKCRQSEYVQTLA-EREVRMAIQQQIEEEDRELQ-LELQRLKIKKRDDIIQFIEEKREYEALQKV-KLNEDNLK 249
XP_001992106        206 AQIHKVQADRHRQQQSALE-EGRQKRHNDEMADANDLQQAiVRRHKKRDELKHMLDECAELQRKMREANAAhKSDKLDVI 284
XP_002059537        205 AQIRKLQAERAQQQLTDLE-EGRQKRHNDEMAHANDLQQAvEERHKKRIELKQMLDEFSALQRSIREANPD-KPDKLDVI 282
WGS:AAPU:GI15335-PA 205 AQIRKLQAERAEKQMADLE-EGRLKRYNDEQAHANDLKEGiESKFRKRTELKKMLDDFSALQRSLREANPV-PPDKLNVI 282
XP_002031153        198 AQITEGRTKRIQDHRIAVAeGRQELKECKEIVEQGILKDA-ITKANQRKVLLESLDQSAAMLKQTREAYAL-AQKNKPER 275
WGS:AAPP:GF19498-PA 279 IQITEAREKRQKDQQAMVEeGRRERREFLAKVEEDRIQDI-IKLAKSRRELMEGLQQSVAQSSANREVTAK-ASKGKPER 356
6U42_5A             296 -IADYILQKEMREQSLAAEKERI-AKEKEMETAR-LRAMQERAADKQSELDELRARRYQEAKEREWRQKERAYAERQASM 372
XP_002061397        248 -NLDTQNQMDDRKKKLDQERIEI-RRKQEEISQL-LGQQVAKLETDKRQKDNLLLDLLESEHNAKEEARVRQQQQQIAFE 324
XP_002073380        207 -ALRTQTQMDERKQRLDHERLEV-RRKHEEITTQ-LGYQLYKLDSEKRQRENVLLDLLESEYKAKDDERFRHQLQQEEMD 283
XP_002054568        250 -ALEKQSEIAEQKRQREEAKLET-QRKQEEIKMR-VGHQVFEIEERLRQRYSLLFDLLIAEYKAKDDERYRQQLKQEQFN 326
XP_002000071        250 -AFEIQLEDAKHREEMEKARLEA-IRKQQEISSR-IGQQVLEVENRKRQRDNVLLDLLQAEYKAKGDERYRQQLQQEQLE 326
XP_001992106        285 -VMEAVSPVTKSFINQQLQQRHD-DIERRRRISDgLGQQLTEMRSKKDAHDNMLADILICERQAREKKRAHQDIQKRCNQ 362
XP_002059537        283 -VMEALGPVTGSFIKKELQRRLD-DIERRRLISDgLGQELSEIRGKKDARDNMLADILICERQAREKKRAHQDIQKRHNQ 360
WGS:AAPU:GI15335-PA 283 -LMEAVGPVTKSFMRKAIQQKLD-ILERRRLISDgLSVKLAEIRGKKEAHDNMLADILVCERQAREKQKARQEVLDRHNQ 360
XP_002031153        276 gLLDALGPVTAAYVSKARKRRLDeIEARDINAAR-LGFQLSQIKHDLESRDQLITSLLIREHKAKENAKALEQARTKMAK 354
WGS:AAPP:GF19498-PA 357 gILDALGPVTATYVGMERKRRHDeIEARDINAAR-LGFQLSQIKHEIEAREQLITNLLIRECQAKDSELALNQARQKMAL 435
6U42_5A             373 QQELAN---ARTAQqASKLKQKAE-MARLEHDEFMR-VLDVNRAKEYDELQQTVN---AMTLNSKYKEELLAQIQANEER 444
XP_002061397        325 RMRAKGeleAYRLQ-VQQRNMDQE-EQKRLEV-----VARKDVSADNQEAIDRQQklnDFQKRKDYGKMLLSMIEDNQRK 397
XP_002073380        284 RIRVKKdleRYRAE-VLQRNKEQM-EMRRQELA----AEQELLLTINPDAIEKEQelaEQQRRRDHGNILLSMIKENQRK 357
XP_002054568        327 RQRARQ---ELELY-RAEVNERNI-EKARKKH-EQT-VERNLMCPDEGPDGINKKdiqERQRRKEHGVLLLSMIEDNNRK 399
XP_002000071        327 RQRARQeleRYRAE-AYERHLEAV-RKKKEQA-----VDKDSFSIDIHACGDNEMl--iRQQRKEHGALLLSMIEENNRK 397
XP_001992106        363 KLQVAKdliGQQEE-------QQF-YRDKDEALTATiPITPTCFMERQYQQASEReatTREINLRAHQEIAIDIEHNAQV 434
XP_002059537        361 KLQVAKdliNQRKE-------QQF-YREKDEALAKTiKTDATSFMQRQYQQASEKeaaSHAISAKTYDGIAADIVNNARV 432
WGS:AAPU:GI15335-PA 361 KLQVAKdliEQHEE-------KEF-FREKNELLFSKiPTDATSFMQRQYQQTLAKeaaRREINQKGTAGSAAEIANNARL 432
XP_002031153        355 KQEIREqllSQREE--------QKfFRDKGVQDALVmPKDPMCFGERQYRMQVAQrenTRRLDVQCYQDMANMVVEAKNN 426
WGS:AAPP:GF19498-PA 436 KREIRDqllSQRDE--------QKfFRDKAIQQSMLkPKDPTSFGERQYRNQVAQaenTHRLDVQAYKDLAVMIEAGKKR 507
6U42_5A             445 RKRERSHYLEEGARLREAAEKERQLLLQIKDRKLGE 480
XP_002061397        398 RAQTLAEDAEFFNMKAKEDKELRERVHQERIVMLNA 433
XP_002073380        358 RANAMAENVQFFSMKDKADKELQERIQRERLEMLDT 393
XP_002054568        400 RAEAAAENMLFFDSKAKAEAERQERIQEERLQMLGS 435
XP_002000071        398 RAEAAAENIQFFNLKAKSDAERQARIEEERLRMLSS 433
XP_001992106        435 RAALVEEERQIKQALHEMELDMERRIDEERMRLLHE 470
XP_002059537        433 RAAAVEEERMIKQALHDMELDMERRIDEERMRVLHA 468
WGS:AAPU:GI15335-PA 433 RALAIEEDRMLKQAILDMEADTERRIDEERMRLLRA 468
XP_002031153        427 RKIAAQEVVDIVQAVYNQQNRQDELVAIERMKLLSK 462
WGS:AAPP:GF19498-PA 508 RAENAEEMRQMNKRVYDLQDIQDKLVAVERMEILGK 543
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