Conserved Protein Domain Family
WTX

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pfam09422: WTX 
WTX protein
The WTX protein is found to be inactivated in one third of Wilms tumours. The WTX protein is functionally uncharacterized.
Statistics
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PSSM-Id: 462794
Aligned: 14 rows
Threshold Bit Score: 440.055
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007252366   59 ELARSKTHDGLvTDVpSDLEGSKKEdscss----------dllhsA------------------------PVEGVSLAPV 104 
E1C2Q8         57 GMVRSRTHDGL-ADA-VLESGKKEDagggea--------qgkdapS------------------------RAAGGLGGSA 102  chicken
XP_005990615   56 GMVRSKTHDGL-ADVvV-EGSKKGEssssdq--------lntdtnT------------------------KTVTSASVSL 101 
EDL95988       89 GLNKSKTHDGL-SESsHGPEDVVVE--------------------E------------------------TELSTPLSKS 123 
Q5JTC6         89 GLSKSKTHDGL-SEAaHGPEDVVSE--------------------G------------------------TGFSLPLPEL 123  human
4_pfamImport    1 ELVRSKTHDGL-TGSnNEAVGQRGE----------------------------------------------GLTSLEAGP 33  
3_pfamImport    1 ELVRSKTHDGL-TSSnSDADGQRGE----------------------------------------------GLAILEAGP 33  
F1QGH6         60 ELVRSKTHDGLiTDTpSELDSHRKEesass----------dqlhaG------------------------TPDGVSTAPL 105  zebrafish
Q8N7J2         99 GLVRSRTHDGL-AEVlVLESGRKEEprgggdsggggggrpnpgppR------------------------AAGPGGGSLA 153  human
VTJ64886      101 GMVRSRTHDGL-AEVvVLEGSk-----------------------KeepraggdsgggrgggrpnpgpprAAGTGVGSLA 156  woodchuck
XP_007252366  105 RSAITKSFSFFSLLR-----RNSTRVGDGA------ATLGHRGRGLKGLFSSMRWRRKPPPREDSSEIqevaKEVKEGDV 173 
E1C2Q8        103 SSSVAKSHSFFSLLR-----KNGRPENGKAaenaeqRAGGRQKKGLKGIFSSMRWHRKDKIGKEERGE----ASEIPSGL 173  chicken
XP_005990615  102 SSSVAKSHSFFSILK-----RNGKSENGKGens-dqKAGNRQKKGLKGLFSSMRWHKKDKSHKEEKED----SSENQSSI 171 
EDL95988      124 PSQFPSSQSAHGALEigsrhKTSVTEAVEKagvekvPSVHKPKKGLKGFLNSIRRHRKSKVSGADQSGlgakELE----- 198 
Q5JTC6        124 PCQFPSSQSAHGALEtgsrcKTSVAGATEKavaekfPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEpgakGPE----- 198  human
4_pfamImport   34 VRSLSKSLSFFSFLR-----RGSFRTSENGg-----TGIVRRGRGLKGFFSSMRWRRKEKTSEAEGEEvegkKAR-DTDA 102 
3_pfamImport   34 VRSLSKSLSFFSLLR-----RGSFRSGENGg-----AGLVRRGRGLKGFFSSMRWRRKEKTNEVDAEEaerkAEKdgevg 103 
F1QGH6        106 RSSITKSFSFFSLLR-----RSSSRAGDGT------TTVGRRGRGLKGLFSSMRWRRKPQIQEDTle---vaKEVKEGDL 171  zebrafish
Q8N7J2        154 SSSVAKSHSFFSLLK-----KNGRSENGKGepvdasKAGGKQKRGLRGLFSGMRWHRKDKRAKAEAAEg---RAPG-GGL 224  human
VTJ64886      157 NSSVAKSHSFFSLLK-----KNGRSENGKGdpadasKAGGKQKRGLKGIFSSMRWHKKDKRGKEEEKEa---HAAGQGSL 228  woodchuck
XP_007252366  174 ILPstsnkvetleDSVTLTLEPTVRVFEECPTEDNSGTWDKNSLEEVKSSNE-ESrkSSCSLVq---------------- 236 
E1C2Q8        174 IMP----------GSLTASLECIKEETPKPLSETPNGAGDTGVESQQEKRGGdAC--VSAEEPqagggesrds----ktp 237  chicken
XP_005990615  172 ILP----------GSLTASLECVKEKVQKPLSELENDREQAEKESPCESNSNeVN--ASVNKPeamdcgepscm--ldnn 237 
EDL95988      199 -------------GTRTMSQEHVSSIS-LPSSE------EIFRDAIKENTKPqDApgPKMSPArehfslttek---tack 255 
Q5JTC6        199 -------------RVRARPHEHVSSAPQVPCFE------ETFQAPRKENANPqDApgPKVSPTpepsppatek---mack 256  human
4_pfamImport  103 TESet-------lKDITLTLEP----------PPHHHQEDCASAETGSNLQAsDTptTSVTMTpthcvamp-------gp 158 
3_pfamImport  104 --------dperaKDITLTLEP----------PPHHHQVDCGDAAASPDp---EThsTSVTITpplcvvamp------gq 156 
F1QGH6        172 ILSsssgs-vkteKDMTLTLEPLPQVFEESPLPGDSDKWKVASMQGIQGTNEvECgnCGPSVSqq--------------- 235  zebrafish
Q8N7J2        225 ILP----------GSLTASLECVKEETPRAAREPEEPSQDAPRDPAGEPAGGeEVp-APADRAparscreaeglahpgdt 293  human
VTJ64886      229 ILP----------GSLTASLECVKEETPRAACEPETPSQDAPRDPAGELGGGeEVpaSA-DRApartcreaespgcpndk 297  woodchuck
XP_007252366  237 -----eITEESPAPSPLRVPTEGPLRANTSGSACLTSIPASAMTPPLEH--------------SSVDPPSEPSVDRLC-S 296 
E1C2Q8        238 pgedpaAAARRLEELCGERPDPGAGEVGTAKDAAITGDIPITTIPPVEPhcdsgqetaaapdpSSVDPPSEQSIDRIC-L 316  chicken
XP_005990615  238 knikegIATEIKQESLALLPDTSKEQIQVKEAEAITGDIPEQGTALTKPkcvsape-taapepSTIDPPSEQSIDRIC-L 315 
EDL95988      256 npekltMTCASEFMQPKPILEASSLEEPHTSETEGKVVT------------------------GDANPPNGPVGDQLS-L 310 
Q5JTC6        257 dpekpmEACASAHVQPKPAPEASSLEEPHSPETGEKVVA------------------------GEVNPPNGPVGDPLS-L 311  human
4_pfamImport  159 sgepdsPFPYTPTDSPLRPSI-------QKAKASISSLTPSLTTPPLDRc-------------SIGDQPSEPSVDRLCsI 218 
3_pfamImport  157 scepdsPIPYTPTDSPLRPPT-------QKAKASISSLTPSLATPPLDRc-------------SNGDPPSEPSVDRLCsL 216 
F1QGH6        236 ----htVTEESPAPSPLRVQTGGLQNHKHSSSTHLSSIPTCALTPPMEH--------------STADPQSEQSVDRLC-S 296  zebrafish
Q8N7J2        294 gargedAAGHRRAE-------PGPGEVRTAEDASRTGAVPVKTVPLVDSeggsgra-paapdpASVDPPSDPSADRIC-L 364  human
VTJ64886      298 sargedAAGHRRAEKPRAPPESGAGEVHTAEDASRTGDVPIKTVPLVDSecgsgrasavpdpsS-VDPPSDPSADRIC-L 375  woodchuck
XP_007252366  297 MFTDVTSLKSFDSLTGCGDIIADQEEDSGnggSATSSGTGSSSGGCGGRRvigaatercspvkpplppqvts----rvsi 372 
E1C2Q8        317 MFADVTSLKSFDSLTGCGDIIADQEEDVGggsGGCEKSTPGAGKLGAPKK------------------------------ 366  chicken
XP_005990615  316 MFADVTSLKSFDSLTGCGDIIADQEEEGG---NGGDKAAPAEKGQGTSKK------------------------------ 362 
EDL95988      311 LFGDVTSLKSFDSLTGCGDIIAEQDMDSM---TDSMASGGQRANRDGTKR------------------------------ 357 
Q5JTC6        312 LFGDVTSLKSFDSLTGCGDIIAEQDMDSM---TDSMASGGQRANRDGTKR------------------------------ 358  human
4_pfamImport  219 LFTDVTSLKSFDSLTGCGDIIADADEE-G---PGGN----VPPPPQQHSA------------------------------ 260 
3_pfamImport  217 LFTDVTSLKSFDSLTGCGDIIADAEEDg----PGGN------------ARarappp------------------------ 256 
F1QGH6        297 MFTDVTSLKSFDSLTGCGDIIADPEEDSGnggSATSSGTGSSSGGCMGRRlsgagtnsercspakpplppqvsslasiha 376  zebrafish
Q8N7J2        365 MFSDVTSLKSFDSLTGCGDIIADQEEEAG---PSCDKHVPGPGKPALSKK------------------------------ 411  human
VTJ64886      376 MFSDVTSLKSFDSLTGCGDIIADQEEEAG---PSCDKHAPGPGKPVLSKK------------------------------ 422  woodchuck
XP_007252366  373 spylsshqrmssspkkpqGSGIVAYMGGGEEMASPE-------------------------GVNDADMQGLW---HMLPQ 424 
E1C2Q8        367 ------------------HPTMVAYQGGGEEMASPD-------------------------QVDDTYLQEFW---DMLSQ 400  chicken
XP_005990615  363 ------------------NSNIVAYQGGGEEMASPD-------------------------EVDDAYLQEFW---DMLPQ 396 
EDL95988      358 ------------------SSCLVTYQGGGEEMALPDdddneeeeeedeeveledeeeevkdGEEDDDLEYLWasaQIYPR 419 
Q5JTC6        359 ------------------SSCLVTYQGGGEEMALPDdddeeeeeeeev--eleeeeeevkeEEEDDDLEYLWetaQMYPR 418  human
4_pfamImport  261 ------------------GSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW---HMLPS 294 
3_pfamImport  257 ------------pqphpaGSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW---HMLPS 296 
F1QGH6        377 scympahqrpraapkkpqGSGVVAYMGGGEEMASPE-------------------------GVDDADMQGLW---HMLPQ 428  zebrafish
Q8N7J2        412 ------------------NPGVVAYQGGGEEMASPD-------------------------EVDDTYLQEFW---DMLSQ 445  human
VTJ64886      423 ------------------NPSVVAYQGGGEEMASPD-------------------------EVDDTYLQEFW---DMLSQ 456  woodchuck
XP_007252366  425 KGED-------SPALPRSdpi------vhhPPG---------------RQEKKHPQVKSLGLSKIPVcgis-------kt 469 
E1C2Q8        401 TEETetgggggGGGGTKT------------PEGlken--------rgtEGAQNRVAVKRGGLNQIPI------------- 447  chicken
XP_005990615  397 TEESp------SEQQNQAtppsnpteqkkcPEEav------------------gnTVKLLDIGKRSV------------- 439 
EDL95988      420 FNMNlg---yhTAISPSHqgymlldpvqsyPNLglge------------------------------------------- 453 
Q5JTC6        419 PNMNlg---yhPTTSPGHhgymlldpvrsyPGLapge------------------------------------------- 452  human
4_pfamImport  295 AGES-------SPALPRQyqpssstltstyPPRsnspsal--rpsaqrSAERKAPQVKSLGLSKIPVvggagsragkppl 365 
3_pfamImport  297 TGDN-------SPALPRShqtpsttptstyPPRattnaagchllsahrSADRRLPPVKALGLSKIPVvgaaggraakppi 369 
F1QGH6        429 KDED-------SPAPRRAepv------lhhAPA---------------RLEKRPPQVKALGLSKIPVsgss-------kt 473  zebrafish
Q8N7J2        446 TEEQgp---epQEGAAKVaaale---tkvvPETpkdt--------rcvEAAKDASSVKRRRLNRIPI------------- 498  human
VTJ64886      457 TEDQgq---gpQEGAAKVaaale---tkvvPETskda--------rsvEASKDVSLVKRRRLNRIPI------------- 509  woodchuck
XP_007252366  470 gKQQSAHPSPP--PTDKELHDAPPSDEGYWDSPTPGPE---DED---NGFTRRDGLLRDSCSGDALYDLY-DLDSPGAGG 540 
E1C2Q8        448 -HLNNKEEQKG--REKEQHEGVPNSDEGYWDSTTPGPE---EDS---TTSIQKETLPRDSYSGDALYDLYaEPDENPPGG 518  chicken
XP_005990615  440 --TNSDNSDDS--IEKEPQECIPNSDEGYWDSTTPGPE---EDSg--NTFVQKESLPRDSCSGDALYDLYaDPDESLAGM 510 
EDL95988      454 ----------lltPQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVHRDCLPRDSYSGDALYEFY-EPDDSLEHS 519 
Q5JTC6        453 ----------lltPQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVRRDCLPRDSYSGDALYEFY-EPDDSLENS 518  human
4_pfamImport  366 pHAHGRHPVSP--GEKE-----LLSDEGYWDTPSATPTatpDESg--LQRNQKIALSRDSCSGDHLYDLYnDPEEEGEDQ 436 
3_pfamImport  370 pHAHGRHAASP--GEKE-----PLSDEGYWDTPTATPTatpDESg--QQRNRKTALTRDSCSGDHLYDLYnDPEGAGEDV 440 
F1QGH6        474 gKQQPSRPSPP--PVDKELQDAPPSDEGYWDSPTPGPE---DED---STFLRRDGLLRDSCSGDALYDLY-DPDSPSAAG 544  zebrafish
Q8N7J2        499 -EPHPKEEPKH--PEKEQQEGVPNSDEGYWDSTTPGPE---EDS---SSSGKKAGIPRDSYSGDALYDLYaDPDGSPATL 569  human
VTJ64886      510 -ESHPKEQPKHpeKEKEQQEGVPNSDEGYWDSTTPGPE---EES---ASSGKKAGIPRDSYSGDALYDLYaDPDGSPAVP 582  woodchuck
XP_007252366  541 SDd--DDNMSSPTPSTgDLK 558 
E1C2Q8        519 PP---EEEVTCMPRSK-PVS 534  chicken
XP_005990615  511 AS---DEEMSSLSESK-PLS 526 
EDL95988      520 PP---GDDCLYDLRGR-NSE 535 
Q5JTC6        519 PP---GDDCLYDLHGR-SSE 534  human
4_pfamImport  437 RGd--NDVNSTPSPSA-EFK 453 
3_pfamImport  441 EQegdEDLNSTPSPSS-EYK 459 
F1QGH6        545 SD----DDASSPTKSAgDLK 560  zebrafish
Q8N7J2        570 PGgkdNEETSSLSRLK-PVS 588  human
VTJ64886      583 PA---NEETSCLSRLK-PVS 598  woodchuck
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