Conserved Protein Domain Family
SMP_TEX2
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cd21675: SMP_TEX2 
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in testis-expressed protein 2 (TEX2) and similar proteins
testis-expressed protein 2 (TEX2), also called transmembrane protein 96 (TMEM96), is a transmembrane protein with uncharacterized biological function. Diseases associated with TEX2 include Wernicke-Korsakoff Syndrome. This model corresponds to the SMP domain of TEX2, which may be implicated in lipid transport.
Links
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Statistics
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PSSM-Id: 439231
Aligned: 212 rows
Threshold Bit Score: 109.504
Created: 14-Apr-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #  ##   #   #                      #     #                
Q8IWB9        823 WVNALLGRIFWDFlg----ekYWSDLVSKKIQMKLSKik----lPYFMNELTLTELDMGva-vPKILQAFKPYVd-hQGL 892  human
CCC46546      280 AFNLVIARLFFANtg----tsRLRDLLVEKIRRKLRKasa-klpKNIDGSITLEHLDLGgq-vPLIDVVSDPIVspnGEI 353  Trypanosoma v...
XP_004335321  487 WINALTSRFWFNFrnseelvvVIKTFLETKMKAKLAEkk----lAGFLERIDVVDLSLGdf-vPKMSGIKILPQrrsGEL 561  Acanthamoeba ...
XP_004352943  646 YLSILIARHFEDMrt----ssIMRHVLMKKLGGKLSAvr----rPPALGPLVLEDFDLGqsmkDIFKGMRACTTdipNEM 717  Acanthamoeba ...
EPY33249      384 VFNILITRLFFENts----snRLHDILTEKIQDKFAAisr-slgHNVKGNIYLDGLVIGge-vPLISSVSEGTIspsGDF 457  Strigomonas c...
CCW65843      292 VLNSLLARLFFENtr----tlGLHNLFVGKISKKLESvsk-rlpEHVKGCITLDCLVIGge-vPLFNDVSAASLsscGSL 365  Phytomonas sp...
CCW70263       39 TANMLLSRFFFQSmr----reGMTTLIKKQIQEKLNKlaqskfpRDLQGHIYLDDFIIGkh-iPSIGNVSDARFganGEV 113  Phytomonas sp...
CUG86909      294 VLNLLAARIFFENts----grDFEHFVRGKIEAKLNVle---lpSPLSGHIEVADITIGge-vPLISGVSFASFstnGEI 365  Bodo saltans
CCM13801      322 VFNLLIARLFFENtr----anTLHDLLEEKIKKKLARvsk-slpPQLRGNIFLDGLDVGge-iPLISNVSDPAPsksGDT 395  Leishmania gu...
SYZ63773      478 TLNMFLSRFFFQNmr----ldNFSDVLIKLVRKQLRElpskkfpRDLGGELILDDFLIGtq-iPWISNVSEPRVsanGEV 552  Leishmania br...

Feature 1              #          # # #                                                           
Q8IWB9        893 WIDLEMSYn-----GSFLMTLETKMNltklgkeplvealkvgeigkegcrprafcladsdeesssagsseeddapepsgg 967  human
CCC46546      354 ELDFNLSYr-----GGLMLGLRFGMKvhav-------------------------------------------------- 378  Trypanosoma v...
XP_004335321  562 GIDLVLDYrgedrpAFVKFTGNVWVTqkt--------------------------------------------------- 590  Acanthamoeba ...
XP_004352943  718 LGEIDINYs-----NGVSLRVSTFLTkgi--------------------------------------------------- 741  Acanthamoeba ...
EPY33249      458 EFGFDILYr-----GGLVLLVHFAITyrdi-------------------------------------------------- 482  Strigomonas c...
CCW65843      366 SFDFDVLYr-----GGLILSIRFSITyrgi-------------------------------------------------- 390  Phytomonas sp...
CCW70263      114 GFDMNFCYkg--gdEGFSLYFRLALTyrgi-------------------------------------------------- 141  Phytomonas sp...
CUG86909      366 GFDFDLHYr-----GGFRVVFAASFYvksi-------------------------------------------------- 390  Bodo saltans
CCM13801      396 EFDFDVLYr-----GGLALKIRFSILyrdi-------------------------------------------------- 420  Leishmania gu...
SYZ63773      553 GFDFNLVYkg--geGGFSLFFRLALTycgi-------------------------------------------------- 580  Leishmania br...

Feature 1                                                                     # #   # #         # 
Q8IWB9        968 dkqllpgaegyvgghrtskimrfvdkitkskyfqkatetefikkkieevsntPLLLTVEVQECRGTLAVNiPPPPTDRVW 1047 human
CCC46546      379 -------------------------------------------------rtpDIIFNIGLLQLSNRMRLSvGPPPSKKVW 409  Trypanosoma v...
XP_004335321  591 --------------------------------------------------ciPFCITATLHSLTGKMHIHcAPWPAERFS 620  Acanthamoeba ...
XP_004352943  742 -------------------------------------------------vqiPLVVVINIHLLAGKLKVYcPADVSAKWW 772  Acanthamoeba ...
EPY33249      483 -------------------------------------------------kvpDIVFTIRVLELAGRMRMNiGPPHTHKFW 513  Strigomonas c...
CCW65843      391 -------------------------------------------------rvpDIIFHIKVLELAGRARFSvSPPPTQLCW 421  Phytomonas sp...
CCW70263      142 -------------------------------------------------ripHIVFSVKFHHLEASLYVSvSPPPSERFW 172  Phytomonas sp...
CUG86909      391 -------------------------------------------------rvpQLLFHVHVVEISGRMHVSiGPPPTNKFW 421  Bodo saltans
CCM13801      421 -------------------------------------------------rvpDIIFSIKVLELAGRVHFVvGPPPTRKLW 451  Leishmania gu...
SYZ63773      581 -------------------------------------------------hipHIVFSVKLLELETTMHVSiGPPPSKKFW 611  Leishmania br...

Feature 1         # #         #                            #  ##      # ####   
Q8IWB9       1048 YGFRkpPHVELKARPKLGEr-------eVTLVHVTDWIEKKLEQEFQKvFVMPNMDDVYIT 1101 human
CCC46546      410 LGGSrtPHLQLDFSQEVATndgllhtflKILPDLSLIVSNVVKVKLFEdMVLPSMEDFPLF 470  Trypanosoma vivax Y486
XP_004335321  621 VSFYsvPVMDIRLESVVGGdkr----qiRNFPKLNNLILNKLTNILIEkTVMPNRRYITIP 677  Acanthamoeba castellanii str. Neff
XP_004352943  773 ACFNrlPELNVGITLYIDGrkl----pvSSLPKLRHWVFHAIQNMVRDrLVWPARLKFRFP 829  Acanthamoeba castellanii str. Neff
EPY33249      514 LGCPrpPELRLDISQEVVKegll-gnliSLLPDLGEIISNVVREKIFEdMILPKYDDFPWP 573  Strigomonas culicis
CCW65843      422 IGTStlPQLRLQFTQEVPShdgilhiltKIMPNMNQLVSDLVRVKLFEdMVLPNMEDFPWP 482  Phytomonas sp. isolate EM1
CCW70263      173 IGCHvpPELQVEVHQGCASgrgllhrilISFPNLSTFFTNLIKNYFFKeMVLPFLDDFPLP 233  Phytomonas sp. isolate Hart1
CUG86909      422 IGFHspPNVRLEFTQEVAShegvlssilSWIPDLSETISNFVKVEMFEdMLLPNLDDYALP 482  Bodo saltans
CCM13801      452 LGGPqpPQLRLEFTQEVAShdgilnavlRLLPDMSKIASNIVKVMLFEdMVFPNMDDFPLP 512  Leishmania guyanensis
SYZ63773      612 IGAHklPIVRLEVHQGCASgrgvlhrilTALPNLSGIVTNLIKLYLFSdMVLPYMDDFPLP 672  Leishmania braziliensis MHOM/BR/...

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