Conserved Protein Domain Family
Cybc1_Eros

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pfam15169: Cybc1_Eros 
Cytochrome b-245 chaperone 1 / Eros
Cytochrome b-245 chaperone 1, also known as Eros (essential for reactive oxygen species) in mice, is a transmembrane protein that may play a central role as a chaperone critical for expression of gp91phox and p22phox and hence for the cytochrome b558 heterodimer.
Statistics
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PSSM-Id: 405793
Aligned: 14 rows
Threshold Bit Score: 206.797
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0D2D7         2 YMQVESRTGTLLHLKRNPSIRSWSLLVGISSVGLAA-AYYSTDTW---LWKLFYVAGCAFVALQNLEDWEEAIFDKKSGK 77  tropical clawed...
XP_005809692   3 YMTVETNSPTLLHLKRSPGIRSWSLLVGIASAGLAA-AYYSSDSV---PWKLFYVAGCLFVALQNMEDWEEAVFDKTRKL 78 
XP_007250184   3 YMVVEEHTADVLRLKRSPGIRSWSLLVGIASVGLAA-AYYSSDSV---LWKLFYVTGCLFVALQNMEEWEEAVFDKSKGN 78 
Q6DGA7         3 YMIVEKHTSELLHLKRSPGIRSWSILVGIASVGLAA-AYYSSDSI---LWKMFYVTGCFFVALQNMEEWEEAVFNKSKNE 78  zebrafish
XP_003217139   2 YMIVENHSKSVLHLKRSPSIRSWSLLVGISSVGLAA-AYYSEDSL---GWKLFYLAGCCFVAVQNLEEWEEAIFDKGAGK 77 
XP_415607      2 YMLIETRTSSLLHLTRSPGIRSWSVFVGIASIGLAA-AYYSADSL---AWKLFYMAGCFFVAAQNLEQWEEAVFDKNKGT 77 
XP_003770533   2 YMQVETRTGSLLHLKRSPGIRSWSLLVGILSIGLAA-AYYSGDNI---GWKFFYVTGCLFVAVQNLEDWEEALFDKTTGK 77 
XP_011433412   3 gVRVREETDEQLKLVKEPSLQSFGIVIAFMACGYGA-AVYSEDSS---LWKLVYVVSGLFVGLACIEDWEYCDFNRTTNE 78 
EGC32650       1 -MKIIKTTPNELVLISRNRLKEWSLAFAISSIGLLP-FLHQSDELfikAAKVVFFITFVLVGLLGIHEEYNIEFNIKKRK 78 
Q54IN9         1 -MRIVKTTSNELVLVHSNRLKEWSMGLAIASIGLLPtIFHTSDELfikMSKVVFIITFILIGLLGIHEEYYIEFNVKKRK 79  Dictyostelium d...
Q0D2D7        78 AILITYSLYKKLLTLCKGGQEQ-VVVLLKEIRDVNVEEERVRYFGSGYVIVLRFVTGISHPLTQSAVLGARSDVEAVAKE 156 tropical clawed...
XP_005809692  79 VELKTVSLYALVLTMWRRGQER-IVLDLTQLCDICVEEERVRYLGKGYHVMLRLAAGISYPLTQSATVGGRSDVEVVASL 157
XP_007250184  79 IELKTFSLYALILTLWKKGHEK-VLLDLRHLRDISVQEEKVRYLGKGYVLVLRMATGFSHPLTQSATLGGRSDIDALAAL 157
Q6DGA7        79 IELKTFSLYTMLLTLWKRGHEK-VLLDLRHLRDVSVQEERVRYLGKGYLVVLRLATGFSYPLTQSATLGSRSDVEALAAL 157 zebrafish
XP_003217139  78 IFLKTFNLYKKLLTLSKAGHEQ-VVVPLDEIRAVNVEEEKVRYFGKGYLVVLRFGTGFSHPLTQNAVMGCRSDVDALAKL 156
XP_415607     78 VCLKTFNLYKKMLTFSKGGSEQ-VVALLHEIRDVNVEEETVRYFGKGYLVVLRFVTGFSHPLTQSAVLGCRSDVEAVAKL 156
XP_003770533  78 VILKTFNLYKKILMASRVCHEQ-VVVGLNDIKDVNVIEEKVRYFGKGYTVVLRFATGFSHPLTQSAVMGHRSDVEVIAKL 156
XP_011433412  79 LRQKRYTVYDKILHLFSTKNDQiVVTSLSDIVDVEVEEQYVRYFGNTYQTVMVYDTGIRIGVTESFIYGNKSDQEAIADK 158
EGC32650      79 VLME----YKNILELIARQEGRvMVLDLDQVRSSSVQEVK-EGKKTLFKLVLDYSDGLKIGLTETYFY-YPDLIESIKTD 152
Q54IN9        80 MTME----YRNIIEVLTMQPGRnMVLELDQIRGAVIQEIK--EKKPLYKLAIDYSDGLKIGVTETCYF-FPDQITEIKNS 152 Dictyostelium d...
Q0D2D7       157 LTKFLEFDLVGSrpQAVEESNDSESDEALDT 187 tropical clawed frog
XP_005809692 158 LKRFLRLDQTQR---KQQDYEDYGEDDSTDS 185
XP_007250184 158 LKRFLGLDALHQ---RLSQEEEDEYGNEDDD 185
Q6DGA7       158 LKRFLGLEELQQ---RLADDDYPDDDDGIED 185 zebrafish
XP_003217139 157 ITNFLELNKVPAy-QNFEDSSESDATDEEEP 186
XP_415607    157 VISFLELDRAES--QDVYESSETEASDADEP 185
XP_003770533 157 IINFLELRQPESp-KDLSQSSDSDVDEPRHq 186
XP_011433412 159 IRTFLRLGERPG---VVNGDTSSSSGDEEDf 186
EGC32650     153 INKWLTENNVVS--NKDKDLYGSDDEDDDDQ 181
Q54IN9       153 INKWLSDNGIIG--NNKNNKNNKNEEDEDYS 181 Dictyostelium discoideum AX4
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