1OMX


Conserved Protein Domain Family
Glyco_transf_64

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pfam09258: Glyco_transf_64 
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Glycosyl transferase family 64 domain
Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.
Statistics
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PSSM-Id: 430488
Aligned: 20 rows
Threshold Bit Score: 255.296
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1OMX_A        30 FTLIMQT--YNRTDLLLRLLNHY--QAVPSLHKVIVVWNNvgEKGPEEL-----------WNSLGPHpIPVIFKPQTANK 94  
Q28F88        60 FTLIMQT--YNRTDLLLKMLNHY--QAMPGLSHVIVVWNNv-GQDTPQEl----------WESFGPHpVPVTFKKQKVNL 124  tropical clawe...
Q08C36        66 FTIIMQT--YNRTDVLLRLLNHY--QAVPHLQCIIIVWNNp-GETPPRRl----------WDELGPHpVPVLFREQRVNR 130  zebrafish
Q3TSR0        53 FTLIMQT--YNRTDLLLRLLNHY--QAVPSLHKVIVVWNNv-GEKGPEEl----------WNSLGPHpIPVIFKPQTANK 117  house mouse
XP_001625539 625 FTVVMLT--YERELVLMEAIQRL--VGLSYLNKVVIVWNS--PLAPSLS-----------LHWPDIG-VPVHVVRTTKNS 686 
Q9XZ08       714 FTIVMLT--YEREQVLMDSLGRL--YGLPYLHKVVVVWNS--PKPPLDD-----------LRWPDIG-VPVAVLRAPRNS 775  fruit fly
Q9LY62        74 YTLLMNT--WKRYDLLKKSVSHY--ASCSRLDSIHIVWSE--PNPPSESlkeylhnvlkkKTRDGHE-VELRFDINKEDS 146  thale cress
Q9C975        48 ITVLINGysEYRIPLLQTIVASY--SSSSIVSSILVLWGN--PSTPDQLldql----yqnLTQYSPGsASISLIQQSSSS 119  thale cress
EAY20414      62 LSIIIVTh-APRKKFIRTQLKRIafGQVPHLKEIFIYWADr-KNPLPDLsf--------fGFKLNDGhIPVNILPTTKEF 131 
Q84WB7       518 FTLATMTy-DARLWNLKMYVKRY--SRCPSVKEIVVIWNK---GPPPDL-----------SELDSA--VPVRIRVQKQNS 578  thale cress
1OMX_A        95 MRNRLQVFPEVETNAVLMVDDDTLISAQDLVFAFSIWQ--QFPDQIIGFVPRKHV-ST---SSGIYSYGGfelqtpgpgN 168 
Q28F88       125 MRNRLQSFPEIQTQAVLMMDDDTLVSAYDISFAFSIWQ--QFPDRIVGFVPRKHV-SS---PSGIYSYGSfelkaphteT 198  tropical clawe...
Q08C36       131 MRNRLMMHPDVKTDAVLMLDDDILLSVPDISFAFSVWK--QFPDQIVGFVPRKHV-SS---ASGVYSYGSfelqdpdkgG 204  zebrafish
Q3TSR0       118 MRNRLQVFPEVETNAVLMVDDDTLISAQDLVFAFSIWQ--QFPDQIIGFVPRKHV-ST---SSGIYSYGGfelqtpgpgN 191  house mouse
XP_001625539 687 LNNRFLPYDVIETDAILSIDDDVELRHDEILLAFRVWR--ENRDRIVGFPGRYHA-WDs--VRNRWTYVSn--------H 753 
Q9XZ08       776 LNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWR--EHRDRVVGFPGRYHA-WDlgnPNGQWHYNSn--------Y 844  fruit fly
Q9LY62       147 LNNRFKEIKDLKTDAVFSIDDDIIFPCHTVDFAFNVWE--SAPDTMVGFVPRVHWpEKsndKANYYTYSGwws----vwW 220  thale cress
Q9C975       120 LNARFLPRSSVDTRAVLICDDDVEIDQRSLEFAFSVWK--SNPDRLVGTFVRSHG-FDl--QGKEWIYTV---------H 185  thale cress
EAY20414     132 VSERFKPPQNLTTQTILAMDDDLLISGSELDRAFVVYIknNFTNRIFGLRTRSC-------PSGHYRIFe---------Y 195 
Q84WB7       579 LNNRFEIDPLIKTRAVLELDDDIMMPCDDIEKGFRVWR--EHPERLVGFYPRF--------VDQTMTYSAekf----arS 644  thale cress
1OMX_A       169 GDQYSMVLIGASFFNSKY-LELFQ---K-QPAAVHALIDETQNCDDIAMNFLVTRHTGKPSgi-fVKPINMVNLEKETN- 241 
Q28F88       199 GDMYSMILIGAAFFHSDY-LRLFE---Q-LPASVHNMIDQTQNCDDIAMNFMVANHLGKASgv-lVKPTDMRNLEKEAGs 272  tropical clawe...
Q08C36       205 GDRYSMILVGASFFHRRF-LKQFQ---E-QPAEVHTLLDRTQNCDDIAMNFIVARQLSKRPsgvfVKPVHMSNLEKDASs 279  zebrafish
Q3TSR0       192 GDQYSMVLIGASFFNSKY-LELFQ---K-QPAAVHALIDETQNCDDIAMNFLVTRHTGKPSgi-fVKPINMVNLEKETNg 265  house mouse
XP_001625539 754 SCELSLILTGAAFIHRYY-TYLFT---HwMQQSIREKIDEFMNCEDIAMNFLVSHITRKPP----IKVTSRWTFVCSSCp 825 
Q9XZ08       845 SCELSMVLTGAAFVHKYY-LYLYT---YhLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPP----VKVTSRWTFRCPGCp 916  fruit fly
Q9LY62       221 SGTYSMVLSKAAFFHKKY-LSLYT---NsMPASIREFTTKNRNCEDIAMSFLIANATNAPA----IWVK-------GKIy 285  thale cress
Q9C975       186 PDKYSIVLTKFMMMKQDY-LFEYSckgGvEMEEMRMIVDQMRNCEDILMNFVAADRLRAGPi--mVGAERVRDWGDARNe 262  thale cress
EAY20414     196 NKPYTMALTNFAFLNVKM-LEAFN---KpEYSKMVDYITENRNGEDILMNFIIAKEFQLPPivmkLDVLHLGIFD----- 266 
Q84WB7       645 HKGYNMILTGAAFMDVRFaFDMYQ---SdKAKLGRVFVDEQFNCEDILLNFLYANASGSGKaveyVRPS-LVTIDTSKFs 720  thale cress
1OMX_A       242 G------YSGMWHRAE-HFLQRSYCINKLVNIYDGMPLKYSNIMI--S 280 
Q28F88       273 G------YTGMWHRAE-HLLQRSFCLNKLAEIYSTMPLKYSSIMI--S 311  tropical clawed frog
Q08C36       280 G------FVGMWHRPE-HMLQRSYCLNKLAQIYGHMPLRYSNIMI--T 318  zebrafish
Q3TSR0       266 -------YSGMWHRAE-HFLQRSYCINKLVNIYDGMPLKYSNIMI--S 303  house mouse
XP_001625539 826 V--------SLWSDKS-HFEERHQCINYFEKVYGYMPLLRTQYRA--D 862 
Q9XZ08       917 V--------SLSEDDT-HFQERHKCINFFSRVFGYTPLLNTQYRA--D 953  fruit fly
Q9LY62       286 Ei----gSTGISSIGG-HTEKRTHCVNRFVAEFGKMPLVYTSMKAvdS 328  thale cress
Q9C975       263 EveervrDVGLSSRRVeHRKRRGNCIREFHRVMGKMPLMYSYGKVv-N 309  thale cress
EAY20414     267 ---------GFSAKSG-HLDKRSNCCKKFSEFFG-ENLVEKY-----E 298 
Q84WB7       721 G-------VAISGNTNqHYRKRSKCLRRFSDLYG--SLVDRRWEFggR 759  thale cress
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