Conserved Protein Domain Family
Bbox1_ZBBX
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cd19818: Bbox1_ZBBX 
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins
The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380876
Aligned: 13 rows
Threshold Bit Score: 87.0348
Created: 7-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #        #  #    #  #    #       #     
A8MT70        133 VCGQCENKaALLVCLECGEdYCSGCFAKvHQKGALKLHRTTLL 175  human
XP_014431299  134 ACGQCENKnALLVCLECGEdYCGSCFAKvHQKGALKLHRMIPL 176  Chinese soft-shelled turtle
ELU12382      137 GCGQCEQKaAHVSCIECGEdYCANCFASfHLKGALKKHRSVPV 179  Capitella teleta
XP_019864244   93 QCGQCDQYhASMMCIECVEnYCNMCFVKiHHKGSLSKHHVRPL 135  Amphimedon queenslandica
PAA70289      174 RCGQCEDRaAAVLCPECAEeYCARCFAAfHLKGALRKHRSLPL 216  Macrostomum lignano
XP_013382875   20 KCGQCEQKaANVSCLECGEdYCAACFASfHIKGALRKHRSMPV 62   Lingula anatina
PIK48550      179 ACGQCEAKaVSLTCMECGEnYCTTCFAKfHLKGALRNHRSIPY 221  Japanese sea cucumber
XP_018119227  126 ACGQCESKsALLMCLECGEdYCSACYAKiHQKGALKLHRTRPI 168  African clawed frog
XP_002593334  135 PCGQCEAKkAVLLCEDCGElYCTACFAQfHMKGALRNHNAIPY 177  Florida lancelet
XP_007888009  133 TCGQCETRrPAMVCVECGEdYCSSCFAKfHQKGALKLHRYMPF 175  elephant shark
PFX32542      366 GCGQCERTkATLVCIECEEkYCVSCFMSfHQKGALTKHTTQSI 408  Stylophora pistillata
AAI33912      132 VCGQCEVQlAGLMCVECGEdYCAGCFVRfHQKGALKRHRLVPV 174  zebrafish
KOF91944      135 QCGQCEVNkADFCCLQCTEvYCSSCFASyHRKGALRKHRSISL 177  Octopus bimaculoides

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