5ULJ,5BTH,3FQD


Conserved Protein Domain Family
RAI1

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pfam08652: RAI1 
RAI1 like PD-(D/E)XK nuclease
RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease. It is required for 5.8S rRNA processing. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteriztic to the PD-(D/E)XK nuclease superfamily.
Statistics
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PSSM-Id: 462550
Aligned: 117 rows
Threshold Bit Score: 54.829
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ULJ_D       236 VD-CVW-DYIPEDGk-DVLSHYMELKTTRIL-----ESNGQVV--NFE-KKLFKTWAQCFLMGIRKVVYGFRDDSFFLRD 304 Scheffersomyces...
EFN64237     209 ID-GISsQQHITDTliGKTFEMIELKTLSIRqyneiGTEQHYKygTMRvNKVITWWSQNYLAGIERLICGLRNRNEEVRM 287
EGI70723     203 ID-GIFsRQPITDTlvNKRFEIIELKTYPMYninmqKNNR-----KIScERVSMWWSQNYLVKTNKIIFGLKDKKQKVRK 276
Q6C4A3       206 VD-CVFdPCA------KGTSRYGELKTSREV-----HNAKDGE--ILE-RKMNRAWAQSFLLGVKHIIYGYRTGDHKLAA 270 Yarrowia lipoly...
ABN68449     269 IDaCKDiTK-------DGLSNYIELKARAIP-----SGPKGRAnsSFQ-RKLLSAYCQNKLIGSQNLVIGFRSPELKVSS 335
EGW34192     245 ID-CAIkSE-------PGLCNYVELKTHSKS-----ADDKIKTvnKLN-KKLLEAYCQNKLVGCQHLVMGYRTLDFKLAS 310
EMG48523     225 ID-CAIvKQ-------PGTSNYVELKTHTKL-----PNDKYATvnKLN-KKLLSTYIQNKFVDCQHTVIGFRSDDLKLAA 290
Q59QN5       231 VD-CSIdKE-------TGLENYIELKTHTKL-----ADDKISTinKLN-KKLLSTFIQTKFIDCQHSIIGFRSTDLKIAS 296 Candida albicans
CCE42699     223 ID-CAIsKM-------PGLSNYVELKTHSSL-----PDDKLKTanKLQ-RKLMALYCQNKFISCNYSAIGFRTTDFRLSS 288
XP_007587696 234 VD-SVWdDKVEG----RKNQNYVELKT-RVCnnfshQSDKDKE--NYE-RKQMKYWAQSYLIGCPKIIVGRRSRDGRLMM 304
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