Conserved Protein Domain Family
SLC6sbd-TauT-like
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cd11496: SLC6sbd-TauT-like 
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain
This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 271387
Aligned: 31 rows
Threshold Bit Score: 759.424
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #                                                             
XP_414303     43 RDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSiGGLGVW-KLAPMF 121 chicken
XP_002122580  16 REKWKSKIDFVFGVAGGSIGLGNVWRFPYLCYKNGGGAFLIPYVLFLVGAAVPIFFLEAAIGQFTSrSVSSAW-DMFPLM 94  Ciona intestinalis
XP_002121211  11 RQKWAKPFDFLFSTVGYVVGLGNLWRFPYLCFENGGGAFLIPYTLSVIFIAIPVIILETSFGQYCQqGVSKSW-NRVPLF 89  Ciona intestinalis
XP_002127069  11 RQKWEKPFDFLFACAGYFVGLGNIWRFPYLCFENGGGAFLIPYLLSVAFMGIPFIMLETSFGQCCQsGIMKAW-DKVPLF 89  Ciona intestinalis
XP_002126541  13 RETWGGKQEFILALIGYSVGLGNVWRFPYLCYDNGGGAFLIPYAIFVVLAGIPLFFLEISLGQYTQqSCVKVWsKLVPAM 92  Ciona intestinalis
NP_505873     10 REQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFILETSWGQLMSvGGLGMF-KICPIF 88  nematode
XP_784181     29 RVGWGNKMDFIMACIGYAVGLGNVWRFPYLVYKNGGGAFLIPYFISLVLCGVPIFFMEISLGQQLQtGGISVW-EIYPIL 107 purple urchin
NP_493910     30 RGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQkGAMEMW-LMCPLF 108 nematode
EFX67299     135 RGGWSNEWDFLFSCISVSVGLGNIWRFPYLCFKNGGGTFLVTYFIAMVFCGIPIFYQEVAIGQYLGvGGMTLVaELAPIM 214 common water flea
EFN82579      62 RGGWDNKLDFLFSCISVSVGLGNVWRFPYLCYKNGGGAFLITYGIAMLFCGIPIFFQEVAIGQYLGaGGMSLVgQLCPLL 141 Harpegnathos sa...

Feature 1                                                                                        
XP_414303    122 KGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFtt--tLPWKHCENPWNtdRCFSNYTLant------------------ 181 chicken
XP_002122580  95 RGIGFASMTIIMNLNTYYMAVLAWSLRYVVASFes--pLPWTTCHNAWNsdRCFVYGSNtsasenfeenmtssqwnmtsl 172 Ciona intestinalis
XP_002121211  90 KGVGLAGMITIFHSSVYYVIILAWAAKYLVASFqf--pLPWTSCGNSWNteSCVEVGRRdvlnvtgnia----------- 156 Ciona intestinalis
XP_002127069  90 KGVAYAGVVCVFHSNVFYIVILSWVSKYIVASFss--pLPWSVCGNPWNseNCVEMNVRmnqtnlte------------- 154 Ciona intestinalis
XP_002126541  93 KGIGYGSAVVNFMCAIYFVLVMSWSVLYFVHSCip-gpLPWTSCGNWWNseHCVLNANYkgmnatmlqqvsntsg----- 166 Ciona intestinalis
NP_505873     89 KGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFtm-sdVPWKNCDHAWNtpNCRSEYVKipcdsnrtiaeffnvkvlthd 167 nematode
XP_784181    108 KGVGFAGATISAILNTYYIVIVAWSLLYFFYSFrt--kLVWGDCDNEWNdfFCNDPIYQtncsapdgffc---------- 175 purple urchin
NP_493910    109 RGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIaw--vFPWETCNNYWNdaTCVTGKENftelarika------------ 174 nematode
EFX67299     215 KGVGYATMTVVFLIDIYYSIIIAWTLFYLIASFtalpgLPWQSCENSWNtlNCFLPTSNisil----------------- 277 common water flea
EFN82579     142 QGVGYATMTIVFFLDVYYCIIISWTLFYLISTFvnlpeVPWRGCDNWWNtdDCFDATEGsksihgrtny----------- 210 Harpegnathos sa...

Feature 1                                                                                        
XP_414303    182 -------------------------tnMTSAVVEFWERNMHQMTDGLEKPGQ-IRWPLAITLAIAWILVYFCIWKGVGWT 235 chicken
XP_002122580 173 ppvvetssnetgffntssafntssndvRVSSVIEYWERGVLGKSSGVDEIGS-VQMPLFGCLLVAWLIIYFCIWRGIAWT 251 Ciona intestinalis
XP_002121211 157 -----------------yndpgrntslETTAAEEFWSKQVLQSSDGIENIGS-ILPDLVLYFLLLWVGLYICTFKGIKWS 218 Ciona intestinalis
XP_002127069 155 --------------------hqlnatkGVSAAEEFWTKEVLGMSSGIDQVGS-IRTDLLVNILLLWIGVYFATFKGVKWL 213 Ciona intestinalis
XP_002126541 167 -----------fasalhttpnktnnttIYSPENEFWNNYVLRKSDGIENIGSlENWPLILCFFGSWVVIYLCVFKGARTS 235 Ciona intestinalis
NP_505873    168 hih-eykkqffvgekmnwtvcsaadlsVVSPVKEFWNHRVLGISSGLENPGG-IRWDLALFLLLVWIICYLCIFKGVKWT 245 nematode
XP_784181    176 ----------------tsngtfinkteGESPAQQFWENRVLGISDGIDNIGG-LRWDLVGCLALGWILTYLCIVKGVKQT 238 purple urchin
NP_493910    175 -------------------lvasagghTQTSVEQFWEKRVLHDTGDISEFGG-IQWELFFIMAAAWLIVYFALWKGITQA 234 nematode
EFX67299     278 ------------------------hndSVSAVEEFWSRRVLAITDGIDDAGA-MRWELFGVLILSWMFVYFIIWKGINQS 332 common water flea
EFN82579     211 -----------------tttienntchHTTPVEEYWEQRVLGITSGIETIGN-IQYELLGCLVVGWLLVYFIIRRGLHQS 272 Harpegnathos sa...

Feature 1                                                                                        
XP_414303    236 GKVVYFSATYPYVMLLILFFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNV 315 chicken
XP_002122580 252 SKVVYFTATFPLFMLLVLFIRGVTLDGASDGVSYYLTPNITKLQEPLVWVDAATQVFYSYSLCNGIMVAMGSYNNYHQNL 331 Ciona intestinalis
XP_002121211 219 SKIVYVTATLPIVLIIIILVHTSQLDGASNGIYLYLTPNMTKLANPSVWISAATQATFSFGSGRGSMLVMSSFNQYNHNF 298 Ciona intestinalis
XP_002127069 214 SKVVYVTATLPILLIIVVVVRGCTLEGAYDGIYFYLVPDLTKLAKVEVWVSAATQVAYSTGIGLASLVLLGSYNQYHHNF 293 Ciona intestinalis
XP_002126541 236 GKVVYVTAILPYVMLLILLIRGLTLEGASTGIMFFLRPDFSKLLSSQVWMQAGGQIFYSYGICFTVLYAFGSYNPYNNNC 315 Ciona intestinalis
NP_505873    246 GKVVYITASFPYMMLFCLLIRGLTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNKFNNNV 325 nematode
XP_784181    239 GKIVYFTALIPYVILLALLIRGLTLPGSSDGIYYFINPDWDRLKTPTVWIDAATQIFFSYGVGIGSLISLGSYNPIRNNS 318 purple urchin
NP_493910    235 RKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNC 314 nematode
EFX67299     333 GYIIWFTALFPYVILCVLVVRAVTLDGASDGLLYYITPKWDLLLTSGPWIDGATQIFFAYSIGTGALPALGSYNKFNHNC 412 common water flea
EFN82579     273 GKIIWFSALFPYVVLFILLGRAVTLEGSYDGLLYYVTPRWKELLTPGPWIDGATQIFFAYSIGTGALPALGSYNKFHHNC 352 Harpegnathos sa...

Feature 1                                                                                   #  ##
XP_414303    316 YRDSIIVCCINSCTSMFAGFVIFSIVGFMANvtKRPIADVAASGPGLAFLAYPEAVTQLPiSPLWAILFFSMLLMLGIDS 395 chicken
XP_002122580 332 YRDTIVLSLLNSGTSFFAGFTVFSVLGFMAKeqNTTIDLVAESGPGLVFIAYPKAITLMPlPNLWGALFFLMIFLLGLDS 411 Ciona intestinalis
XP_002121211 299 LRDAVTIGICDTVASFLSGFAVFASLGFMAKqlNTTVLDVAKSGPGLVFIAHPQSISLLPhPQIWSCLFFITLILLGFDS 378 Ciona intestinalis
XP_002127069 294 FRDSILIGVINSMSSFVSGFAVFSSLGFMAKqlNTTVQDVAASGPGLVFIAFPQSISLLPfPQLWSSIFFFTLLLLGFDS 373 Ciona intestinalis
XP_002126541 316 YKQSVILASTCSLTSIFASFVVFSIIGHMSFvqGKDIDAVATSGPGLVFLVYPVGLSLLPaPNLWSVLFFATLFMVGIDT 395 Ciona intestinalis
NP_505873    326 YKQALTVCFVNSGTSVFAGFVIFSFIGFMATqqEKSVAEVAQAGPGLLFLAYPSGILQLPyTQFWSCLFFLMVLFLGVDS 405 nematode
XP_784181    319 VIDTIVVGVVNAGTSLFAGFVIFAILGFMAHeqGVPVSEVVDEGPGLTFVAYPTAVYYMPgAPAWAVIFFAMLIMLGLDS 398 purple urchin
NP_493910    315 FKDAITMCFINGCTSITAGFAVFSILGYMSHvaQKDISEIVKPGVGLAFLAYPEVASNLPmKQVFAVLFFLMITILGLDS 394 nematode
EFX67299     413 YRDAIITCIVNTFTCLIAGVVTFSILGNIASatNSSIESVVSSGPGLVFITYPEVVLRLPgAPIWAILFFIMLAILGIDS 492 common water flea
EFN82579     353 YRDAIITCVVNTLTCLLAGCVTFSILGHIAQeqQTQVSEVVKSGPGLVFLTYPEVVLKLPgASLWAIIFFIMLLILGIDS 432 Harpegnathos sa...

Feature 1                                                                                        
XP_414303    396 QFCTVEGFITALVDEFPkll--rnRREIFIAVVCIVSYLIGLSNITQGGIYVFklFDYYSASGMSLLFLVFFECISISWC 473 chicken
XP_002122580 412 QFIGQESFIAAISDLKPnlfnkpwRREKLVAGVCGVQFLIGIIMITQGGVYVFnmYDNYAAAGWCLFFIGVCECVTVSWL 491 Ciona intestinalis
XP_002121211 379 EFVFLEVFVTFIVDCSSrirsyrwHREVTTAIVCTVMCLIGLSMVTEGGIYVFeiYNNYAVAGWCLFLLATTELIAIAWV 458 Ciona intestinalis
XP_002127069 374 QFVMVECAVNFFIDGSArirsyrwHREIVTAIICVCTGLVGILMVTEGGIYFFeiYNAYAVTGWCIFLIAACEVIAISWV 453 Ciona intestinalis
XP_002126541 396 QFAGVESCVTIFLDLWPnvgkgkyGRELVSAMVCLLFIVLGLPLLTNGGIYIFelFNMYAVSGIALLWLAFFQSITIGWI 475 Ciona intestinalis
NP_505873    406 QFCTMEGFFTAIIDEFPqirrkkyGREIFVGVICVISYLIGLTTVTEGGFYVFqlFDFYAASGWALLWLLFFECIAISWS 485 nematode
XP_784181    399 QFCVVEGLATSLMDEFPqyg-lrkNRSLFLAIFCFIDFLLGLLCVTEGGMYFFqlMDSYGASGICLLWVAFWECASVSYG 477 purple urchin
NP_493910    395 QVCMMEGLFTALEDAFPil---rkYKKQSLGIFCLFFFCIGIPMVTHSGSHWLtlFDAYGASGYALLFVVFFEVVGLAYG 471 nematode
EFX67299     493 EFCMIEAFVTGIVDNWPnql--rkYRRLFVVSTIIVIFLLSLPMITEGGVYLFqvMDYYSASGMSMLFLVFFQTISINWI 570 common water flea
EFN82579     433 EFCIVESFITGMVDYWPdrl--rpHRIKFTIAICLIMFALGIPMVTNGGIYIFqlMDFYSASGMSILWVCFFQTIAISWI 510 Harpegnathos sa...

Feature 1                                                                                        
XP_414303    474 YGVNRFYDniqEMVGYRPCIWWKLCWSFFTPIIVAGVFIFSAVQMT-PLTMGS--YVFPKWGQGVGWFMALSSMvlIPGY 550 chicken
XP_002122580 492 YGITDFWGhvcHMLGFKPRVPWFKYAWAVVAPVLTSSVFIYSLVQYePLTYNRt-YIYPMWAQAVCWCLALSAIlwIPFY 570 Ciona intestinalis
XP_002121211 459 YGIDVHFRgmtDMLGPFRGKLYLKLCWKYITPSICLAIIVYYLTGFkLLKIGN--YVFSVWAQFLGHLMSLSSVlfIPGY 536 Ciona intestinalis
XP_002127069 454 YGLDLYFKeitKMIGSVKGKWWLTFCLKFLTPVLSLAIVGYSLAGFrPLKVGN--YVFPLWAQCLGHLMSLSSVifIPGY 531 Ciona intestinalis
XP_002126541 476 YGVDNYYEnvkSMIGYYPSPYFKLCYKFFAPGISLFIFIFYCVKYA-PLTLGQ--YVFPGWANAVGWFLSLTSMlcVPGF 552 Ciona intestinalis
NP_505873    486 LGIDRWYEhmkSMIGYYPSAWWKFCWVFATPSVCFGVLLFGLIKYQ-PLRIDAynYDYPVWGHIFGWFLSLSSMlcIPGY 564 nematode
XP_784181    478 YGIKNFYNrisTSIGFTPGWYWPLSWAALTPAISMGIFLFSLIDYQ-PAKYGEd-YYYPVWGEIIGWMMAIVSMqwVPIY 555 purple urchin
NP_493910    472 FGAHNIRKalhEMIGVTLPKGIEYVWKFCAPATSLVLFVFCVVYYH-PVKYPDg-KDFPFWANAFGWFLSSCSMvvIPGY 549 nematode
EFX67299     571 FGGKRFCScieEMLGKKSSWFLYVCWVFLAPAVMLGIFVFSIVQYT-PVTYGSd-YQYPKWAEILGICISLSSMlwIPLY 648 common water flea
EFN82579     511 FGAQKFCDcvhQMMGIRLNKFWYICWVLLAPVIMAFIFVFQCVQYK-PLKYGSn-YEYPTWAEIVGVCLSLSSMiwIPAY 588 Harpegnathos sa...

Feature 1                              
XP_414303    551 MAYMFLTLKGsLKQRIQVMIQP 572 chicken
XP_002122580 571 AIYRFAVAKGtMYERWIEVTTV 592 Ciona intestinalis
XP_002121211 537 ALYIKLKLKKpFSELGQNVFLE 558 Ciona intestinalis
XP_002127069 532 AIYIKLKTGK-SFAELRRCVPP 552 Ciona intestinalis
XP_002126541 553 FIAEICKSKGsVYQRIRKALNP 574 Ciona intestinalis
NP_505873    565 AIWIWFKTPGtVQEKIKLLCRP 586 nematode
XP_784181    556 AIYIILTTPGsFKDRLRIATSP 577 purple urchin
NP_493910    550 AIYYLFFTNKhLTLKERVRKGL 571 nematode
EFX67299     649 IVYYILTTPGtLREVLTKGVTP 670 common water flea
EFN82579     589 AVYYVIVTPGsIKENILKGMQP 610 Harpegnathos saltator

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