Conserved Protein Domain Family
DUF4521

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pfam15021: DUF4521 
Protein of unknown function (DUF4521)
This family of vertebrate proteins is functionally uncharacterized. The family includes the Chromosome 20 protein C20orf196.
Statistics
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PSSM-Id: 464452
Aligned: 11 rows
Threshold Bit Score: 286.296
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007636933   1 MESQADTPS-SESVESCT-LNLPTACDIRGHeACQGASQAASSKSLSSLESHSFPCSSTADTDSSSLNTEQKeGSWDSEN 78 
XP_014317849   1 MATPQATPD-SQSEESNS-LELPSACDIRDY-VLREPCQEAHSEAASSAEGLSVLSSSEVDPDSGHLNTTQR-DSWASEN 76 
XP_005634867  17 MATQEATPG-SQSEESSV-LDLPSVYDIRDY-ILQRPQQEAGSEAFSSEEALSIPCSSDVDSDTSNLNTEQH-DSGTSEN 92 
Q2KIJ1         1 MATQETTPG-SQTEESNA-LDLPSAYDIRDY-VLQRPSQQTNSEAFSSEEACSIPCSSDVDPDSSNLNTEQN-DSWTSEN 76  cattle
ELV13419       1 MATQENTPG-SQSEESNV-LDLPSTNDIRDY-VLQRPSQEPNSEAFSSVEFLSFPCSSDVDPDTKSQNTEQN-ASWTFEN 76 
XP_018872251   1 MAARDATSG-SLSEESSA-LDLPSACDIRDY-VLQRPSQEANSEAFSSLEFHSFPYSSDVDPDTSNLNIEQN-NSWTSEN 76 
XP_016283390   1 MESQNATSD-HCSEKSSSfLDLSLTYDITQQ-LQQKPRQEASSEASSSMD---ILASFSLDSEASNLNSEQN-DAGTSED 74 
1_pfamImport   1 MDREETSPShHHSEESSI-LDLPSVCDLAEG-FLSPHSTESSEELFNFVDTFPSPLTVFQSLLLNSHAVLDV-PLLLLYN 77 
XP_005042917   1 MEGKETSPS--LTSESSI-LDLPSVCDLAEH-FLPPHSSENSEELYSSGDIFPSPPTGESNPSSAAPAGCSA-EGSEEAD 75 
Q9D112         1 MESQAATPS-SLSGESCT-LDLPAVCDTSSYeASQRVSQ-GSSNSLSSLESHPFLSSSTTDPDSNSLNTEQK-GSWDSEN 76  house mouse
XP_008254506   1 MEAQEATPG-SQSQESCV-LDLPSACDVRDY-VLQRSCQKPDSEAFSSVEFHSFPCSSDVDPETDNLNTEPK-DSWTSEN 76 
XP_007636933  79 FWLDPS---VT--------------GQLETSEEEDGLRKSLDRFYEAFAYPLPGSGDQLSVPVCQCLSQTISELQGQESQ 141
XP_014317849  77 FWLDPS---VN--------------GQPETKAEDEELRKSLDRFYEMFGHPPPASRNPLSASVCQCLSQKIDELQGQESQ 139
XP_005634867  93 FWLDPS---VQ--------------GQTETKAEDDGLRKSLDRFYEMFDHPHPAARNPLSTSVCQCLSQKINELKGQESQ 155
Q2KIJ1        77 FWFYPS---VK--------------GQPETKEEDDGLRKSLDKFYEVFGNPQPASGNSLSTSVCQCLSQKINELKDQENQ 139 cattle
ELV13419      77 FCLDPS---VK--------------SELETKEEDEELRKSLDRFYETFGHPQPVSRNSLSASVCQCLTQKITELRGQESQ 139
XP_018872251  77 FWLDPA---VK--------------GQSE-KEEDDGLRKSLDRFYEMFGHPQPGSANSLSASVCKCLSQKITQLRGQESQ 138
XP_016283390  75 FWLNHS---MA--------------NQPEPV-KDDGLRKSLDHFYEVYGQALPPPEDALSTAVSRRLSQKITELSSQESQ 136
1_pfamImport  78 IWLVPCgsgSG--------------MYEHSSMEDASIRKSLDSFYKTYCKKQPDSMDPTYEAASQCLLKKISELADRDGT 143
XP_005042917  76 MRCYPK---AGlcepsepndaglswMYERDGAEDPSIRDSLDGFYKMYCRKQPERKDPTYQAASQCLSQKISELEQKGGT 152
Q9D112        77 FWLDPS---SK--------------GQLETNEEEDGLRKSLDRFYEAFAHPLPGSGDPLSASVCQCLSQTISELEGQESQ 139 house mouse
XP_008254506  77 FWLNSS---VK--------------RQSETEEEDDGLRKSLDTFYEAFGCLQPASGNPLSARVCQCLSEKITELRGQESR 139
XP_007636933 142 EYALRSFQMARVIFNRDGCSILQRHSRETRFYPLEQGSNSLEDVELTPGLSREIIRFLLEQPVMK 206
XP_014317849 140 KYALRSFQMARVIFNRDGCTLLQRYSRDARFYPLGEGSQSLDDEKPTPGLSKDIVRFLLQQNVME 204
XP_005634867 156 KYALRSFQMARVVFSRDGCSVLQRHSKDAHFYPVGEGSVLLEDEKPTPGLSKDIIHFLLQQNVMK 220
Q2KIJ1       140 TYTLRSFQMARVIFNQNGCSILQKHSRDAHFYPVREGSTSLQDEKLTPGLSKDIIHFLLQQNLMK 204 cattle
ELV13419     140 KYTLRCFQMARVIFNRDGCSALQRHSRDVRFYPLGEGSASLDDEKPTPGLSKDVVHFLLQKNVMK 204
XP_018872251 139 KYALRSFQMARVIFNRDGCSVLQRHSRDTHFYPLEEGSTSLDDEKPNPGLSKDITHFLLQQNVMK 203
XP_016283390 137 KYALHSFQMAQVILNRDGYSVIQSHCKDVHFYPLEEGNASQDTQKPTPGLSTDVISFLLKESKTK 201
1_pfamImport 144 KYTLRCLQMAQLVLNRDGCKVFPNHPTTACFSKPAEGEVMLEDRKRIPGLSDDVLQFLFKQTQIE 208
XP_005042917 153 KYVSRCLQMAQLVLNRDGCKIFPNHSPSTCFSKPAEGEVLLENRRRTPGLSDDILQFLVKQTQAE 217
Q9D112       140 RYALRSFQMAQVIFSRDGCSILQRHSRDTRFYPLEQEGSSVDDEEPTPGLSREVIRFLLEQTVMK 204 house mouse
XP_008254506 140 EYALRSFQMARVVLSRDGCSVLQRHARDTHFYPLGDRSASLEDEKPIPGLSKDIIHFLLQQNVLK 204
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