3N2B,2P3E,1TWI,2QGH,1HKV,1KNW


Conserved Protein Domain Family
lysA

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TIGR01048: lysA 
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diaminopimelate decarboxylase
This family consists of diaminopimelate decarboxylase, an enzyme which catalyzes the conversion of diaminopimelic acid into lysine during the last step of lysine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Statistics
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PSSM-Id: 273415
Aligned: 21 rows
Threshold Bit Score: 516.843
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3N2B_A        28 FNYQEDGQLWAEQVPLADLANQYGTPLYVYSRATLERHWHAFDKSVgdy------phLICYAVKANSNLGVLNTLARLGS 101 Vibrio cholerae...
P00861         2 PHSLFSTDTDLTAENLLRLPAEFGCPVWVYDAQIIRRQIAALKQFD-----------VVRFAQKACSNIHILRLMREQGV 70  Escherichia col...
Q58497        10 TVEIKDGRFFIDGYDAIELAEKFGTPLYVMSEEQIKINYNRYIEAFkrweeetgkefIVAYAYKANANLAITRLLAKLGC 89  Methanocaldococ...
O27390         5 IEVNDKGHLLIGGADAVELADEYGTPLYVIDEMRIRENYRRLYRAFsgey----srfQVFYACKANTNLAVMRILEEEGS 80  Methanothermoba...
Q9X1K5         1 ------------MDILRKVAEIHGTPTYVYFEETLRKRSRLVKEVFegv------nlLPTFAVKANNNPVLLKILREEGF 62  Thermotoga mari...
P31848        16 TTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFgs-------gaNVHYAAKAFLCSEVARWISEEGL 88  Mycobacterium t...
WP_015251780   9 SRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRERAKSFKQAFisag----lkaQVAYASKAFSSVAMIQLAEEEGL 84  Bacillus subtilis
Q55484        33 AVINKNGELEIGGCSVPALVEQFGSPLYILDETTLRQAAQQYRQSFqahy---pgssQVIYASKAWSCLAVVAIAAQEGL 109 Synechocystis s...
1TWI_A         6 TVEIKDGRFFIDGYDAIELAEKFGTPLYVMSEEQIKINYNRYIEAFkrweeetgkefIVAYAYKANANLAITRLLAKLGC 85  Methanocaldococ...
1HKV_A        16 TTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFgs-------gaNVHYAAKAFLCSEVARWISEEGL 88  Mycobacterium t...
3N2B_A       102 GFDIVSVGELERVLAAGGD--------PSKVVFSGVGKTEAEMKRALQLKIkcFNVESEPELQRLNKVAGELgvkaPISL 173 Vibrio cholerae...
P00861        71 KVDSVSLGEIERALAAGYNpq----thPDDIVFTADVIDQATLERVSELQIp-VNAGSVDMLDQLGQVSPGH----RVWL 141 Escherichia col...
Q58497        90 GADVVSGGELYIAKLSNVP--------SKKIVFNGNCKTKEEIIMGIEANIraFNVDSISELILINETAKELgetaNVAF 161 Methanocaldococ...
O27390        81 GIDAVSPGEIYTALMAGFD--------PDRILYTGNNVRDDELQFALDSGVr-INVDSRSQLLRLSEIAPEGl---RISF 148 Methanothermoba...
Q9X1K5        63 GMDVVTKGELLAAKLAGVP--------SHTVVWNGNGKSRDQMEHFLREDVriVNVDSFEEMEIWRELNPEGv---EYFI 131 Thermotoga mari...
P31848        89 CLDVCTGGELAVALHASFP--------PERITLHGNNKSVSELTAAVKAGVghIVVDSMTEIERLDAIAGEAgivqDVLV 160 Mycobacterium t...
WP_015251780  85 SLDVVSGGELYTAVAAGFP--------AERIHFHGNNKSREELRMALEHRIgcIVVDNFYEIALLEDLCKETghsiDVLL 156 Bacillus subtilis
Q55484       110 GFDVVSGGELFTTVSALKQlgwdeaeiAEKIYFHGNNKSVQELQEAIAINCt-IIVDNWLELETLTKLAADSgapvKIML 188 Synechocystis s...
1TWI_A        86 GADVVSGGELYIAKLSNVP--------SKKIVFNGNCKTKEEIIMGIEANIraFNVDSISELILINETAKELgetaNVAF 157 Methanocaldococ...
1HKV_A        89 CLDVCTGGELAVALHASFP--------PERITLHGNNKSVSELTAAVKAGVghIVVDSMTEIERLDAIAGEAgivqDVLV 160 Mycobacterium t...
3N2B_A       174 RINPDVDAKTHPYISTGLRDNKFGITFDr--AAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSlk- 250 Vibrio cholerae...
P00861       142 RVNPGFGHGHSQKTNTGGENSKHGIWYT---DLPAALDVIQRHHLQLVGIHMHIGSGVDYAHLEQVCGAMVRQVIEF--- 215 Escherichia col...
Q58497       162 RINPNVNPKTHPKISTGLKKNKFGLDVEsgiAMKAIKMALEMEYVNVVGVHCHIGSQLTDISPFIEETRKVMDFVVElk- 240 Methanocaldococ...
O27390       149 RVNPLVGAGHHEHCITGGEMSKFGVMERe--APEVYRMAMDLG-FEPVGIHAHIGSGILDPEPFMLAVETLMDIAGRvhe 225 Methanothermoba...
Q9X1K5       132 RVNPEVDAKTHPHISTGLKKHKFGIPLE-----DLDSFMERFRSMNIRGLHVHIGSQITRVEPFVEAFSKVVRASER--- 203 Thermotoga mari...
P31848       161 RLTVGVEAHTHEFISTAHEDQKFGLSVAsgaAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDvvg 240 Mycobacterium t...
WP_015251780 157 RITPGVEAHTHDYITTGQEDSKFGFDLHngqTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGFVLAAEKIFKKLDEwrd 236 Bacillus subtilis
Q55484       189 RLTPGIECHTHEYIKTGHLDSKFGFDPNq--LEAVFTYIAQQPSLHCLGLHAHIGSQIFERQPHKDLGEVLVQWFTKgl- 265 Synechocystis s...
1TWI_A       158 RINPNVNPKTHPKISTGLKKNKFGLDVEsgiAMKAIKMALEMEYVNVVGVHCHIGSQLTDISPFIEETRKVMDFVVElk- 236 Methanocaldococ...
1HKV_A       161 RLTVGVEAHTHEFISTAHEDQKFGLSVAsgaAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDvvg 240 Mycobacterium t...
3N2B_A       251 ----aeGIHIRHLDVGGGLGVVYRDEL-PPQPSEYAKALLDRLERH------R-DLELIFEPGRAIAANAGVLVTKVEFL 318 Vibrio cholerae...
P00861       216 ------GQDLQAISAGGGLSVPYQQGEeAVDTEHYYGLWNAAREQIarh-lgH-PVKLEIEPGRFLVAQSGVLITQVRSV 287 Escherichia col...
Q58497       241 ----eeGIEIEDVNLGGGLGIPYYKDKqIPTQKDLADAIINTMLKYkd--kvE-MPNLILEPGRSLVATAGYLLGKVHHI 313 Methanocaldococ...
O27390       226 ----atGVEFEFIDFGGGLGIPYTPEEePLDIDEFASKITGLFKDKlse-ygLgRPMMCLEPGRYIVGDASYLLTRVNTI 300 Methanothermoba...
Q9X1K5       204 -------YGFEEINIGGGWGINYSGEE--LDLSSYREKVVPDLKR---------FKRVIVEIGRYIVAPSGYLLLRVVLV 265 Thermotoga mari...
P31848       241 efgpekTAQIATVDLGGGLGISYLPSDdPPPIAELAAKLGTIVSDEsta-vgLpTPKLVVEPGRAIAGPGTITLYEVGTV 319 Mycobacterium t...
WP_015251780 237 ----sySFVSKVLNLGGGFGIRYTEDDePLHATEYVEKIIEAVKENasr-ygFdIPEIWIEPGRSLVGDAGTTLYTVGSQ 311 Bacillus subtilis
Q55484       266 ----tyGLPLTELNIGGGLGICYTESDdPPSIEEWAQVAAISVAKAcdr-qnIpYPKLIAEPGRSLVGSACVTAYRVGGR 340 Synechocystis s...
1TWI_A       237 ----eeGIEIEDVNLGGGLGIPYYKDKqIPTQKDLADAIINTMLKYkd--kvE-MPNLILEPGRSLVATAGYLLGKVHHI 309 Methanocaldococ...
1HKV_A       241 efgpekTAQIATVDLGGGLGISYLPSDdPPPIAELAAKLGTIVSDEstavglP-TPKLVVEPGRAIAGPGTITLYEVGTV 319 Mycobacterium t...
3N2B_A       319 KHTE-----H-----KNFAIIDAAMNDLIRPALYQAWQDIIPL-R----PRQGEAQTYDLVGPVCETSDFLGKD------ 377 Vibrio cholerae...
P00861       288 KQMG-----S-----RHFVLVDAGFNDLMRPAMYGSYHHISALaAdgrsLEHAPTVETVVAGPLCESGDVFTQQeggnve 357 Escherichia col...
Q58497       314 KETP-----V-----TKWVMIDAGMNDMMRPAMYEAYHHIINCkV----KNEK--EVVSIAGGLCESSDVFGRD------ 371 Methanocaldococ...
O27390       301 KES------Y-----RKFAGVDAGFNTLLRPAMYGSYHHILVAeR----PLDEPSEKMDVAGNVCESGDLFARD------ 359 Methanothermoba...
Q9X1K5       266 KRRH-----N-----KAFVVVDGGMNVLIRPALYSAYHRIFVLgK----QGKE--MRADVVGPLCESGDVIAYD------ 323 Thermotoga mari...
P31848       320 KDVD-----VsatahRRYVSVDGGMSDNIRTALYGAQYDVRLVsR----VSDAPPVPARLVGKHCESGDIIVRD------ 384 Mycobacterium t...
WP_015251780 312 KEVP-----Gv----RQYVAVDGGMNDNIRPALYQAKYEAAAAnR----IGEAHDKTVSIAGKCCESGDMLIWD------ 372 Bacillus subtilis
Q55484       341 KVVP-----Ni----RTYISVDGGMSDNPRPITYQSVYRVALAnR----MNDEITETVTVAGKHCESGDILVKD------ 401 Synechocystis s...
1TWI_A       310 KETP-----V-----TKWVMIDAGMNDMMRPAMYEAYHHIINCkV----KNE--KEVVSIAGGLCESSDVFGRD------ 367 Methanocaldococ...
1HKV_A       320 KDVDvsataH-----RRYVSVDGGMSDNIRTALYGAQYDVRLVsR----VSDAPPVPARLVGKHCESGDIIVRD------ 384 Mycobacterium t...
3N2B_A       378 -RDLV--LQEGDLLAVRSSGAYGFTMSSNYNTRPRVAEVMVDGN-KTYLVRQREELSSLWALES 437 Vibrio cholerae O1 biovar El To...
P00861       358 tRALPe-VKAGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG-QARLIRRRQTIEELLALEL 419 Escherichia coli K-12
Q58497       372 -RELDk-VEVGDVLAIFDVGAYGISMANNYNARGRPRMVLTSKK-GVFLIRERETYADLIAKDI 432 Methanocaldococcus jannaschii D...
O27390       360 -RQLPe-INEGDVLAIMNAGAYSFSMSSQYNSRPRPAEVLVREG-KVDVVRERETFSDLLRGQN 420 Methanothermobacter thermautotr...
Q9X1K5       324 -RELPe-VEPGDIIAVENAGAYGYTMSNNYNSTTRPAEVLVRENgRISLIRRRETEMDIFKDVV 385 Thermotoga maritima MSB8
P31848       385 -TWVPddIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAG-NARLVLRRETVDDLLSLEV 446 Mycobacterium tuberculosis
WP_015251780 373 -IDLPe-VKEGDLLAVFCTGAYGYSMANNYNRIPRPAVVFVENG-EAHLVVKRETYEDIVKLDL 433 Bacillus subtilis
Q55484       402 -VALPa-AEPGDIMVVAATGAYNHSMASNYNRLGRPAAVLVNQG-QANLILQRETYTDLLRQDC 462 Synechocystis sp. PCC 6803 subs...
1TWI_A       368 -RELDk-VEVGDVLAIFDVGAYGISMANNYNARGRPRMVLTSKK-GVFLIRERETYADLIAKDI 428 Methanocaldococcus jannaschii
1HKV_A       385 -TWVPddIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAG-NARLVLRRETVDDLLSLEV 446 Mycobacterium tuberculosis H37Rv
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