Conserved Protein Domain Family
PPPI_inhib

?
pfam14895: PPPI_inhib 
Protein phosphatase 1 inhibitor
This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes.
Statistics
?
PSSM-Id: 464358
Aligned: 20 rows
Threshold Bit Score: 345.113
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_005623555         16 FTPAVELKEKGKKGKAIHFAETDGPAADRLTDKKfASRDDKSPKAlgkrgqqGNVTLHDAKFVALFLLQDTEMQRicSFT 95 
EDV97731             32 HFDLEHADERYMDTNGYQFLRTLNPTEEVIFRKK-FVRPHTTYDT-------DTVVINDVRDLVLFLMPKEFLSK--KFL 101
WGS:AANI:GJ11249-PA  32 HFDLEHANERYIVTNGYKFLRTIDQEEELIFRQV-FVRPDTTYDA-------DTVVINDVRDLVLFLMPKEFLSP--KLI 101
WGS:AAPU:GI21013-PA  32 YTDLEGQPTRFIYTNGYKFIRTINQDEESVLREQ-FVRSDNSFDA-------DTVIIDDVRNLVLFLMPKEFLNM--QFL 101
2_pfamImport          1 STEKKNKKD-------FVFKESMEEVEELVFRQV-FSRTDKSYDA-------DVIILQDIKNVALFLAPTYIMQK--RFV 63 
XP_003472558         48 FAPTVELKEKGKKGKAVHFTEVDGAASERLTDKKlSSRDEKSIKAsekrgqqGHITLDDVKFVALFLLQDAEMQRicSFT 127
XP_003408756         46 FTPAIEFKEKGKKGKAVHFAEIDGPASDRLADKRsAARDDKSTKAlekrgeqGYVTLDDVKYVALLLLQETEMQRicSFT 125
XP_002007718         32 YSDLEDANERFIMTNGFKFLRTINQEEELIYRQV-FARPENTFDG-------DVVVVNDVRDLVLFMMPKEFLSI--KFV 101
WGS:AAPU:GI11569-PA  32 FFDLENANDRYVDTNGYRFLRTINQEEELIFREL-FARPDTTFDA-------DTVVINDVRDLVLFMMPKEFISR--KFI 101
WGS:AAPU:GI21012-PA  32 HSELGDAGERYIDTNGYKFLRTIDQHEETVFRQV-YVRPGARYDL-------ETIGLDDVRDLVLFMMPKEFLTL--KFV 101
XP_005623555         96 IFMRNKNLDNFLMALLYYLSHYLEknslekqpksyMV--GLVEKKEMELVINKLEAAQ---------KYL-------AQK 157
EDV97731            102 SLIHQPAVHRLIHSLIIYFEYFLR-----------MVefTLIRRDELACKMAQVQSEQtnemkrifsTHLrqyrmlvARN 170
WGS:AANI:GJ11249-PA 102 EFMHKPAVHGLIHALIIYFEYFLR-----------MVefILIRRDELAGNLAKIQSEQtnemkrifsLYLsqyrmlvARN 170
WGS:AAPU:GI21013-PA 102 EFMHHPIVHRLLHGLIIYFEYFLR-----------FVelILIQRDELSDTYQQIKSHNstkikriwsKYLsqyrilvARD 170
2_pfamImport         64 DFVHTKVVDSFLNALIIYFEYFLK-----------VLeyLLIRRDELSGKTPQIQSMDsinikemfsEYLtqyriliARE 132
XP_003472558        128 TFMRNKNLDIFLMALLYYLSYFLEknslekkpksyMV--GLVEKKEMELILSKLVAAQ---------KYL-------AKK 189
XP_003408756        126 TFMKNKNLDNFLMALLYYLSYFLEkislerkpksyMV--ALVEKKEMKLVLSKLDIAQ---------KYL-------AQK 187
XP_002007718        102 DFMHRPAVHRLLHALVIYFEYFLR-----------LVefILIRRDELSGDMAQVQSEQtnevkrifsSHLshfrmlvARN 170
WGS:AAPU:GI11569-PA 102 EFMHKPAVHRLLHALIIYFEYFLR-----------LVefLLIRRDELAGNMAQVQSEQtnemkrifsTNLrlyrmlvARN 170
WGS:AAPU:GI21012-PA 102 TFIHQPDVHRLLHSLILYFNYFLQ-----------LVefILIRRDELSGDKAQVQSEQtnevkriwsTYLsqyrllvARN 170
XP_005623555        158 YCILVLGLA--MPDKHHMccgKE--KISDTQKDWKFFESFYTFCTYVAWIVFRRQHFTEIEEEIGRLFRTNLFNIPRRKR 233
EDV97731            171 YCMIISGEGd-LKKFYHT---KEivNISSKIKDRALHEQLLAVLIQIVWITMHRRAYFIIEMEMNRLFRSEHFLMNRKEY 246
WGS:AANI:GJ11249-PA 171 YCIIIMGESd-MKKFYHT---KEivNISSKIKDRFFHEHFLAVCIQIVWITMHRRAYFIIEMEMNRLFRSEHFLMNRPEY 246
WGS:AAPU:GI21013-PA 171 YTELITGDGd-LHQFYHL---RSklNISATKTDGILYDQFLAVATQIVWITLHRRAYYVIEMEINRLFRSEHFYTKRPEY 246
2_pfamImport        133 YSKIIMENSetIGAFYHM---DPilHISNSVSDQFLHEALIAFSIQVVWIAMHRKSYNVIHGEIDRLVRTNHFSMKLKGC 209
XP_003472558        190 YCILVLGLG--MPDKHHMccgKD--KMSDTQKDWKFFESFFTFCTYVAWIVFRRQHLTEIEEEIGRLFRTNMFNMPRRKH 265
XP_003408756        188 YCILVLGLA--MPDKHHMccgKE--KISDTQKDWKFFESFYTFCAYIAWIVFRRQHLTDIEEEIGRLFRSNMFNIPRRKR 263
XP_002007718        171 YSVIIKGEGd-MQEFYHT---KEvvNISSTIRDRAFHEQFLAVATQIIWITMHRRAYFIIEMEMNRLFRSEHFLMNNIHY 246
WGS:AAPU:GI11569-PA 171 YSAIVMGDGe-LKKFYHT---KEvvNISSTIKDLYFYEYFLAVSTQIVWITMHRRAYYVIEMEMNRLFRSEHFLSNCPKY 246
WGS:AAPU:GI21012-PA 171 YSVILKSEGd-LKKYYHT---KEivHISSKIKDRAFHSQFLAYATQVVWITLHRRAYFIIEMEMNRLFRSEYFLMNRKEY 246
XP_005623555        234 ED----EESGGEKKRMTLVQFRRMMAkrPAIKKAIHMRSPVMSTLLpslrekaqdIFEKKNHQVGIKFPAQMQEHMESLD 309
EDV97731            247 IKftpvERSLLFGRNYKIFNYRVQCS--PLIQDLKHVDHEDMPLLW---------IGERKYRGSDHRIAEVELEYIVPGP 315
WGS:AANI:GJ11249-PA 247 LKftnvERSLLYGRNMKIVNYRSQNS--PMIQELKSVAIEDMPILW---------IGERKYRGSDPRIAELELEYIVPGP 315
WGS:AAPU:GI21013-PA 247 PRftpaERSLLYGRYNKIVNYRNQTS--PLMQEMQNISTADVPIVL---------IGRRKYPGTDPRMLELELEYIVPGS 315
2_pfamImport        210 LElssmEKQVFMVKTIK------QTS--FLIQELINIEHKNLEIVW---------IGVKKYRGNNMRIAKLEFEFIVPNS 272
XP_003472558        266 ED----EELGGEKRRMTLVQFRRMMAkrPAIKKAINMRSPVMSTLLpslrekaqnIVEKK-YQGGARRSAYAGKHTASQD 340
XP_003408756        264 ED----EESGGEKKRMTFVQFRRMMAkrPAIKKAINMRSPVLSTLLpsprekaqnIFEKKFHHGSIKLQAKIQKHLESLD 339
XP_002007718        247 LNfttvERSLLYGRNNKIFNCRVQNS--PMIQELQHVADEDMPILW---------IGERQYRGTDLRIAQVEMEYLIPGS 315
WGS:AAPU:GI11569-PA 247 LKftpvERSLLYGSKCKIFNYRAQIS--PLIQELRNVADEDMPVLW---------IGERKYRGTDARIAQVEMEYIVPGP 315
WGS:AAPU:GI21012-PA 247 LEftpvERSLLYGRNCKIVNYREQRS--PLIQELLHVADEDMPILW---------IGERMYRGSDHRIAELELEYMVPDM 315
XP_005623555        310 SVPMPTV--GILGEPRCLFNphTLLPLDLeenmkSDGRHSS---------LIEKNNMKIQDTLNLVMRT 367
EDV97731            316 QLHLIDVshGILGHPKKLYN--TILSLDW-----PSVRYANfseendpyyIIRQPNLRIPNINEMHVRK 377
WGS:AANI:GJ11249-PA 316 QLRMIDVvhGILGNPKILYD--TILTLDW-----PSVRYANfskqydpysILRQPNLPIPQINEMQVRQ 377
WGS:AAPU:GI21013-PA 316 QLRLIDVqhGILGHPKAVYD--TLLRLNW-----AALRQSTha-----wiTSKQPYLRIPNIENIEEHK 372
2_pfamImport        273 QLSLADLshGILGHPKNLYD--TLLNLNW-----EAVRFAGysqtfdpyrLVRQPYINIPDWDEYNEKH 334
XP_003472558        341 SVPMPVV--GILGEPRCLFNphTLLPIEPeenakASRRNSS---------LIERNSVRIQDTLDLALKS 398
XP_003408756        340 TVAMPVV--GILGEPRCLFNphTLQPLELeettkTPGRHSS---------VVERSNTRVRGTLDFALRT 397
XP_002007718        316 QLNLADLshGILGHPKNLYD--TILSLDW-----PSVRFANfskqydpynLLRQPGLQLPNIDEMQVRR 377
WGS:AAPU:GI11569-PA 316 QLHMIDVahGILGHPKKLYD--TILMLDW-----PSVRFANysiqhdpyfIIRQPSLTLPNFDELKHRK 377
WGS:AAPU:GI21012-PA 316 QLYMVDIshGILGHPKTLYN--TILALDW-----PSVRYSNfslnydpyyMIRQPELHIPNINDMALRR 377
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap