Conserved Protein Domain Family
PP4R3
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pfam04802: PP4R3 
Phosphatase 4 regulatory subunit 3
This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homolog) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement.
Links
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Statistics
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PSSM-Id: 461435
Aligned: 110 rows
Threshold Bit Score: 168.789
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007328979  221 QEEYIKSLIDVLRAAEDL-ESLENLHALCSLMQTILMLNDHTLYEHILEDDIFYGVVGMLEYDPDFP-THKANYRDFLKQ 298 
EEH55088      177 QNGYLRKLLDLFKTCEDL-DDQDGLHMMYRLVRGLVLLNDAALFDELLRDDNVMDVVGALEYDPDLP-VERTQHRVFLRD 254 
EFJ22511      210 EQSYIPKLMELFRLCEDL-ENVENLHMIFRIVKGMISLNDKNVFDTIFSDEHVMDVVGALEYDPELS-SQQ-DHRGFLKT 286 
ERN03083      165 DRTFVPKLTDLFRVCEDL-ENVDGLRLMYKVVKGIISLNSPPIFERIFGDDYIMDIIGALEYDPEVP-QVQ-HHRAFLKE 241 
Q8LPS4        167 DHDFFRNLMGVFKICEDL-ENVDGLHMIFNIVKGIILLNSSQILEKIFGDELIMEIIGCLEYDPGVP-HSQ-HHRNFLKE 243  thale cress
KRH11977      167 YQDFFGKLMDVFRVCEDL-ENMDGLHMIYKIVKGIILLNSTQIFERIFSDEFMMDIIGALEYDPEVS-HVK-HHRKFLKE 243 
XP_006654069  203 YHDFFPQLVNLLRTCESS-GNMDALHMIFRLVKGIIFLNSSAIFDKIFSDDFILEIIGALEYDPEAR-SVQ-NHRYFLKE 279 
XP_006644141  198 ERDFFPKLLDIFRICEDL-ENLDDLHMIFKLVRGIILLNSSSIFDKIFSDEFILDIIGALEYDPDVP-KVQ-KHRAFLKD 274 
EFA75365      165 RDDYLKQLLELFDQLEQS-NDIPNLHHQFTIFKNLILFNDSSIFELLLSEEYLLRMMGVLEYDPEISeQNRIRHREFLSQ 243 
Q54I18        149 KEDLVRSLLDLFDEIEKSgEGGVHLFQIFNIFKNLILFNDTSILEVILSEDYLVRVMGALEYDPEISeNNRIKHREFLNQ 228  Dictyostelium...

XP_007328979  299 AARFRQPIPMQEEVIQRKIHHTYRLQFLKDVVLARALDDSTFNVLNSCIIFNQIDIITHIQSDQMFLKEIVRLFVdedvl 378 
EEH55088      255 SVVFKEVVPIQDADVRAKIHQTYRIGYLKDVILPRVLDDATFGTLTSIMLFNNVEVVLALQNDPTFLKELFARLD----- 329 
EFJ22511      287 QVVFKEAVPIHDVAIVSKIHQTYRIGYVKDVILPRVLDDQTFANMNSMMLANNKAVVSALHSDKTFVSDLFAKLR----- 361 
ERN03083      242 HVVFKEAIPIKDPSVLSKIHQTYRVGYIKDVILPRALDEATIANLNSIVHSNNAYVVSLLKDDNAFIQELFARLR----- 316 
Q8LPS4        244 HVVFKEAIPIKDPLVLSKIHQTYRIGYLKDVVLARVLDDAIVANLNSVIHANNAIVVSLLKDDSTFIQELFARLR----- 318  thale cress
KRH11977      244 HVIFKEAIPIKNTTVLSKIHQTYRVGFLKDVVLARVLDEATVANLNSIIHANNAIVVSLLKDDNTFIQELFARLK----- 318 
XP_006654069  280 HAIFKEAIPIKSASVVSKIHQTYRIGYIKDVILPRVVDDATMASIAAIIHANNAAVVCLLKDDSSFVKELFTKMR----- 354 
XP_006644141  275 HVVFKEAIPIKNASVVSRIHQTYRIGYLKDVILPRVLDDATLASLNTMIHSNNAAVISLLKDDSCFIQELFARMR----- 349 
EFA75365      244 QVIFKEVVKFSSESLISTIHQTFRVQYLKDVVLPRVLDDLTFSTLNSIIYFNNSEIVGQIQKDTTFLQKIFTQIQ----- 318 
Q54I18        229 QVVFKQVIKFPSKSLIGTIHQTFRIQYLKDVVLPRVLDDVTFSSLNSLIYFNNIDIVSQIQNDSDFLENLFSEIQ----- 303  Dictyostelium...

XP_007328979  379 iggaqryqiqlqmmqqqqqqmhqmhqrlqqgpddsmdvdtapkpipsvsppasapissptaysfappddLTEAEINQRRE 458 
EEH55088      330 ---------------------------------------------------------------------NTPRTNPDWDD 340 
EFJ22511      362 ---------------------------------------------------------------------SPDISQNVRND 372 
ERN03083      317 ---------------------------------------------------------------------SPATSVESKKN 327 
Q8LPS4        319 ---------------------------------------------------------------------SPSTSMESKKN 329  thale cress
KRH11977      319 ---------------------------------------------------------------------SPATSPESKKN 329 
XP_006654069  355 ---------------------------------------------------------------------SSNISAESKRE 365 
XP_006644141  350 ---------------------------------------------------------------------LPSISMESKRE 360 
EFA75365      319 ---------------------------------------------------------------------QSPSGSSERRD 329 
Q54I18        304 ---------------------------------------------------------------------KSEKNSEERKD 314  Dictyostelium...

XP_007328979  459 VVLLIQQLCIMGKNVQLPARMALFRVL 485 
EEH55088      341 LVGFLQELCSLAKHLQIQQRGSLFAAL 367 
EFJ22511      373 LIYFLHEFCNLSKNLLSLHRSELFGSL 399 
ERN03083      328 LVLFLQEFCSLSKSLQLVHQMRLFRDL 354 
Q8LPS4        330 LVYFLHEFCSLSKSLQVVQQLRLFRDL 356  thale cress
KRH11977      330 MVHFLHEFCSLSKSLQMVHQLRFFRDL 356 
XP_006654069  366 LVLFLLEFCTLSKSLQPVQQLQLSRDL 392 
XP_006644141  361 LVLFLHEFCTLSKSLPLVQQLRLFRDL 387 
EFA75365      330 LLLFLQELCGLAKNLQIQNKSTFFLSL 356 
Q54I18        315 LILFLQDLCNLAKGLQIQSKSTFFTVV 341  Dictyostelium discoideum
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