Conserved Protein Domain Family
PTP_PTPDC1
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cd14506: PTP_PTPDC1 
protein tyrosine phosphatase domain of PTP domain-containing protein 1
protein tyrosine phosphatase domain-containing protein 1 (PTPDC1) is an uncharacterized non-receptor class protein-tyrosine phosphatase (PTP). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Small interfering RNA (siRNA) knockdown of the ptpdc1 gene is associated with elongated cilia.
Links
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Statistics
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PSSM-Id: 350356
Aligned: 16 rows
Threshold Bit Score: 274.997
Created: 4-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitecatalytic site
Feature 1: active site [active site], 7 residue positions
Conserved feature residue pattern:C x x x x x RClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
EDL41054       25 QAIKGVYSSWVTDNILAMARPSSELLEKYRIIEQFlgqgiKTIINLQRPGEHASCGsaleqesg--ftylpeaFMEAGIY 102  house mouse
EFN88384      129 MAIQNIFSHWVTDDVLAMARPSTAQIIKKDIIAQFqgwsiKTIINLQTSGEHASCGgpleesg---ftydpniFMKNGIY 205  Harpegnathos ...
NP_501178      64 QAIDGLYSTWITSDILAMARLQVEHFDSLGIVEKFktngiQSVINLQESGEHSFCGsgnltsg---fsydpenLMRNGIY 140  nematode
XP_001750238   66 NAFRGVNSTWVTENLLAMSRPLQGAIDAYHLPKKFaeagiTMVLNLQEPFEHSHCGagvnrhg---fsysfesFQQQGVT 142  Monosiga brev...
XP_002906974   40 SPVKGLHADWVADCALAMMRPSSRLMNEYKIAEQFhklniTAVFNLTLPGEHPYCGdglgtsgf--pydpekdLMAENIR 117  Phytophthora ...
CBJ29564      231 AAVNGLHSHWISDSIIGMQRPSSRLIKTYDIVGQFkrkgvTAIFNLTEPGEHPHCGdglekasg--fpylpetFMREGIS 308  Ectocarpus si...
XP_829444      78 TAIEGLISSWVGDDVIASQRPSTSLFRKYSLIEQFrekriTGVLNLQEKGEHASCGpdgiyastgysysgeqdLMRHQIS 157  Trypanosoma b...
XP_001745858  380 QAIPGIFSTWITNDILALARPTQRGVDEFGLLDKLvesrvRVLINLEDHGEHANCGqgnlpgg---fsydldaFAARGVA 456  Monosiga brev...
NP_001315366   51 QAIKGIFSSWVTDDILAMARPSTYLMKRYSIIEQFkqlniKSIINMQLPGEHAHCGpplepdsg--ftyspqsFMDNQIF 128  zebrafish
XP_005993076   77 QAIKGLYSSWITDNVLAMSRPSTEIIEKYNIIAQFqsygiKTVINLQRPGEHASCGnsleqesg--ftylpeaFMEAGIY 154  coelacanth

Feature 1                                               #######                                   
EDL41054      103 FYNFGWKDYGVASLTAILDMVKVMTFALQE--GKVAVHCHAGLGRTGVLIACYLVFAtr-mTADQAIIFVRAK-RPNSIQ 178  house mouse
EFN88384      206 YYNFALKDYGDATMGKLLDMVKVVAFAVQE--GRVAIHCHAGLGRTGVLIACYLIYSlr-vRANDAIRFVRMK-RPSAIQ 281  Harpegnathos ...
NP_501178     141 HYNFPLPDFQACTPNRLLDIVKVVDFALSH--GKIAVHCHAGHGRTGMVIAAWMMYAlg-mSPSQAVDTVRSR-RAKAVQ 216  nematode
XP_001750238  143 VCNCAWVDFGSPPMERALDIVKIMASVIQEg-GKIAVHCHAGRGRTGLIIAAYLIFHnd-yTAAKAIRLVRSQ-RPKTIQ 219  Monosiga brev...
XP_002906974  118 FYNFGWEDMTTPALAFMMDIVKVIASVLLTgrHKVAVHCHAGYGRTGIAIACALIFLhn-iPPELAIRLVRRD-RPGSVQ 195  Phytophthora ...
CBJ29564      309 VYNFSWEDMTTPSMALLSDIIRVALSCLRTg-GKIAVHCHAGYGRTGLVIASILVMMnn-lPPQQAVALVREK-RPTSLQ 385  Ectocarpus si...
XP_829444     158 YYEFPWPDMTAPKQDIVLRSVQVMDSHVKKs-GKVLVHCHAGLGRTGLMIACYLLYAqk-mPSADVIELVRQM-RPGAIQ 234  Trypanosoma b...
XP_001745858  457 VHLFGWADYGVPSMQTALTMVKVAAQALDLq-VAVAVHCHAGLGRTGMLIACILVYVlklvYPRTCVEGCVEHfAHTAPA 535  Monosiga brev...
NP_001315366  129 FYNFGMSDFGVSSLEGMLDAVKVLAFSVQE--GKVAVHCHAGLGRTGVLIACYLVYTcr-iSASEAVHYVRIK-RPRSIQ 204  zebrafish
XP_005993076  155 FYNFGWKDYGVASLTTILDMLKVMSFALQE--GKVAIHCHAGLGRTGVLIACYLVFAtr-mSADQAILFVRAK-RPNSIQ 230  coelacanth

Feature 1                                                               
EDL41054      179 TRGQllcvREFTQFLAPLRNIFsccdpka--havtlaqYLIRQRHLLHGYEARL 230  house mouse
EFN88384      282 TRGQilciQEFEHFVLPQMIVFplhsttgdrkpyslqsYLRKQHNVLHGYEQRT 335  Harpegnathos saltator
NP_501178     217 SKEQv---KTLHEFRLLIRNNGg---------------MIIPKNKMTHISEYVA 252  nematode
XP_001750238  220 TRNQvkflEEFDMYLHPRRAVYhhvpdet--eqltlreALERERTWLVGQNVDI 271  Monosiga brevicollis MX1
XP_002906974  196 TAGQvqfvHDFHAYLNAARVVFalptihd---rftlaeTVEHQNRRLHGAGAVN 246  Phytophthora infestans T30-4
CBJ29564      386 TNAQvsmvGEFANFVRGVRVVY----------------HFTDHARVTLGQHLAQ 423  Ectocarpus siliculosus
XP_829444     235 TSRQvkfiHDFESHLWRLSHTFrvevses---aldidlFLKKQRLLLHGDHADS 285  Trypanosoma brucei TREU927
XP_001745858  536 SSAAs--gEEGANTLRAVEVNGdgp----------slrTFVRQAAQLHGADDQD 577  Monosiga brevicollis MX1
NP_001315366  205 TRSQinlvFDFARLLGSQLAQFpslntrhc-atfslrqYLLRQALLLHGDEART 257  zebrafish
XP_005993076  231 TRGQllcvREFAQFLIPLRNVFaccepka--havtlpqYLIRQRHLLHGYEARQ 282  coelacanth

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