Conserved Protein Domain Family
7tmA_S1PR3_Edg3
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cd15345: 7tmA_S1PR3_Edg3 
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Links
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Statistics
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PSSM-Id: 320467
Aligned: 5 rows
Threshold Bit Score: 454.663
Created: 25-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                  ##  ##
EMP36291      45 GLTTVSFLIICSFIVLENLMVLIAIWKNNKFhnrMYFFIGNLALCDLLAGIVYKVNILMSgKRTLSLSytiWFIREGSMF 124 green seaturtle
Q99500        40 TLTTVLFLVICSFIVLENLMVLIAIWKNNKFhnrMYFFIGNLALCDLLAGIAYKVNILMSgKKTFSLSptvWFLREGSMF 119 human
NP_001076394  31 MCKTAFLMCICALIVIENITVLLALWRNKRFhsrMYFLIGNLALSDLLAGVAYVVNIFTSgRNTFFLSpgqWLLREGSMF 110 zebrafish
Q9PUQ8        31 DPKTIAFLVVCSFIILENLTVLLAIWKNHRFhnrMYFFIGNLALCDLLASVAYLVNLLLSgEKTLQLSpvlWFVREGSMF 110 torafugu
XP_002937075  39 DMTEIVFLIICSLIVLENLMVLIAIWKNNRFhnrMYFFIGNLALCDMLAGIAYIVNICMSgSKTMDISltaWFVREGSMF 118 western clawed ...

Feature 1          #                                                                             
EMP36291     125 VALGASTLSLLAIAIERHLTMIKMrpYDANKKYRVFLLIGTCWLISVSLGALPiLGWNCIsnlpdCSTILPLYSKKYVVF 204 green seaturtle
Q99500       120 VALGASTCSLLAIAIERHLTMIKMrpYDANKRHRVFLLIGMCWLIAFTLGALPiLGWNCLhnlpdCSTILPLYSKKYIAF 199 human
NP_001076394 111 VALSASTFSLLAIGIERHMTMVRLrpCETAGRGRLLALLGACWAVSVLLSALPsLGWNCLdrvhtCSTVLPLYDKSYIAF 190 zebrafish
Q9PUQ8       111 VTLGASIFSLLAIAIERHLTMIKMrpYDASKNYRVFLLIGTCWLVAVLLGALPiLGWNCLgnlpdCSTILPLYTKKYVAF 190 torafugu
XP_002937075 119 IALGASTFSLLAIAIERHLTMIKMrpYDANKKYRVFLLIGTCWLISFSLGALPiLGWNCIedlpnCSTILPLYSKRYVGF 198 western clawed ...

Feature 1        #                                                       #      #                
EMP36291     205 CISIFIAILVAIVILYARIYILVksssrnvtnhsnsERSMALLRTVVIVVGVFIACWSPLFILLLIDVACrvkeCAILYK 284 green seaturtle
Q99500       200 CISIFTAILVTIVILYARIYFLVksssrkvanhnnsERSMALLRTVVIVVSVFIACWSPLFILFLIDVACrvqaCPILFK 279 human
NP_001076394 191 CISVFTALLAAIVVLYVRIYQLVtssgrr-vssrpsDRSLALLRTVVIVLGVFVACWAPLFSLLLLDVGCspeqCPILYK 269 zebrafish
Q9PUQ8       191 CIIVFIVLLLAMSVLYARIYILVksssqkvskhrnsEHAMSLLRTVIIVVGVFIACWMPIFVLLLLDVACer-pCPILYK 269 torafugu
XP_002937075 199 CISIFIAILIAIVILYARIYILVksssrrvtnhsnsERSMALLRTVVIVVGVFIACWSPLFILLLIDVACevktCSILYK 278 western clawed ...

Feature 1         #  #                         
EMP36291     285 ADWFIALAVLNSAMNPIIYTLASKEMRRAF 314 green seaturtle
Q99500       280 AQWFIVLAVLNSAMNPVIYTLASKEMRRAF 309 human
NP_001076394 270 VDWFIALAVLNSALNPLIYTFSSREMRTAF 299 zebrafish
Q9PUQ8       270 ADWFIAVAVLNSAMNPIIYTLASREMRRAF 299 torafugu
XP_002937075 279 AQWFIALAVLNSALNPVIYTLASKEMRRAF 308 western clawed frog

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