Conserved Protein Domain Family
Dendrin

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pfam15498: Dendrin 
Nephrin and CD2AP-binding protein, Dendrin
Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.
Statistics
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PSSM-Id: 464749
Aligned: 6 rows
Threshold Bit Score: 799.147
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004053111  55 MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGG 134
XP_003772402  55 MDPTGGPWVQEPSSHRYGLDKKPPERLLRRAWVPRVLQEATNWGTGHPPEIRPREQEKRKAASQEREAKETERKRRKGGG 134
XP_851155     55 MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEARAREQEKRKAASQEREAKETERKRRKAGG 134
Q80TS7        55 MDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 134 house mouse
XP_003475864  55 MDFQASHWAPGSQSRTCRPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 134 domestic guinea...
XP_008254630  41 mdlQSSHWARGPRSRTCRPRPGSPEPSPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 120 rabbit
XP_004053111 135 AR------------RSPPGR------PRPEPRNAPRAAQLAGIPAPLRPERLAPVGRAPRPSAQPQSDPG-SAWAGPWGG 195
XP_003772402 135 VRswsppglyrsepRSPLGRarggggSRQEPGNVPKTAQPKVRQFPWLPGHLGPAGRPPRPAAQSLRVPGtAARAGLRVG 214
XP_851155    135 AR------------RSPPGR------PRPEPRSGPRVAQPVGPPAPSRPERLGPAGRPPRPSAQPQSDPG-AAWAGPWGG 195
Q80TS7       135 AR------------RSPLGQ------PRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRPSVLPQGDPG-VAWAGPWGG 195 house mouse
XP_003475864 135 PR------------RSPLGQ------SRQEPRNALRAAHPAGLSAPPRPERFGQVGRAPRPPAQPQSDPG-AVWAGSWAG 195 domestic guinea...
XP_008254630 121 AR------------RSPPGQ------PRPEPRNAPRAVQPAGLSGPSRRERLGPAGRAARPSAPPHSETG-AAWAGPWGG 181 rabbit
XP_004053111 196 RRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAAT---PARTEggRTKKR 272
XP_003772402 215 RPSGPPSYEAHLLLRGAAGPIPRKRWDRPPPYVAPPSYDGPHRTLGAKRPPQLPGLPAPLAPAPTlegKEREE--RPKKR 292
XP_851155    196 RRPGPPSYEAHLLLRGAAGTALRRRWDRPPPYVAPPSYEGPHRTLGSKRGPEPPQAPAPAASAPT---PARTEggCAKKR 272
Q80TS7       196 RRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPA---TTRTEggRTKKR 272 house mouse
XP_003475864 196 RRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPERSQGPTSSAPAPT---PARTEggRAKKR 272 domestic guinea...
XP_008254630 182 RRPGPPSYEAHLLLRGAAATAPRRRWDRPPPYVAPPSYEGPHRTLGTKRSPERSQASAASAPAPT---PARTEggSARKR 258 rabbit
XP_004053111 273 LDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARarpePGKGVVEKSLGLAAADLNSGSDSHpqa-kaTGSAGTEiAPAGSA 351
XP_003772402 293 LDPRIYRDVLGAWGIRQGRGALGGFPACGGLG----LGGKTSDKVSGVFLGGLNSNCSES------CSQPGAN-QIARAA 361
XP_851155    273 LDPRIYRDVLGAWGLRQGRGLLGGSPGCGTAAprpeAGKGAAERSLGPAAAGLSAGSDGRpqa-raAGSPSAQtAPAGSA 351
Q80TS7       273 LDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARarpeSCKGAIEKSSGLVAAGLNSAGDSHsqg-ktTGGPGTDaALSRSA 351 house mouse
XP_003475864 273 LDPRIYRDVLGAWGLRQGRGLLGGSPGCAAAKprleFSKGGAEKSPGLATAALNSGSDSHfqa-dvPSSPGTEiALAGPV 351 domestic guinea...
XP_008254630 259 LDPRIYRDVLGAWGLRQGRGLLGGSPGCGAVRarpaSGKGAAERGPVLPAAGLHGGSDRRfqatavAGSPGSGtAPARPA 338 rabbit
XP_004053111 352 TAAPCAPRPAPRSRHHLKGSREGKEG-REQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGEG--AGPETL 428
XP_003772402 362 TLTSGTSQTTARTQVPLRDVSEGERA-GEQSWSRETGGPSPGDQVAQHSQTLPRPWAPGSPREKESPGEGDGyqRSPKLP 440
XP_851155    352 PAARSPPRPAPRARPRLKGSEEGKEN-REQSWLPKCWVPSRKRQPPRQSQTLPRPWAPGGTGWSESPGLRAG--AGPS-- 426
Q80TS7       352 --ISSPPRPVPRSRQHLRGSRKGKEG-SEQIWLPTCWLASPKKPPVRHSQTLPRPWAPGGTGWKESLGQREG--AEHETL 426 house mouse
XP_003475864 352 PATTSPPRTAPRFRHQLQGSREGKEG-RERIWLPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGQREG--VGPEAL 428 domestic guinea...
XP_008254630 339 AAPSSPPRPAPRSRHQLEGSREGKEGrREQVWLPRCWMLSPKKQPSRQSQTLPRPWAPGGTGWRESPGHGDG--PGPA-- 414 rabbit
XP_004053111 429 EGWKGTRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP-GKEEGEGVTVF 507
XP_003772402 441 TDWKETHRAHTVPRSPHSSAGENGVFVIDATCVVIRAQFVPTPQIQHVQLLSSPGPRNGGNSLAFQKP-GKEEGEEEQAF 519
XP_851155    427 EGGKGTRRAHTLPRSARGPARGEGVFVIDATCVVIRSQYVPTPRTQHVQLLPAGVPRAAGDAPSPPGP-SQEEGEGAAAL 505
Q80TS7       427 EVWKVTRRAHTLPRISRGPAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPcHEEEGEGAAAN 506 house mouse
XP_003475864 429 EDWKETRRPHTLPRSSRGLARGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGESRVVGDGPRQPNG-SKEEGERASVF 507 domestic guinea...
XP_008254630 415 -----ARRAHTLPRCSRRPAGGEGVFVIDATCVVIRSQYVPTPRAQQVQLLPSEMVRVVGDAPSPPKP-GPQQGEGASGS 488 rabbit
XP_004053111 508 PSPCQKRLSSSRLLHQPGGGRg--GEA-----EGGRPGDSSL-EERTFRILGLPAPEVNLRDAP----TQPGSPEHqalg 575
XP_003772402 520 TSPCQKLLQNSRLFDQLSKGF---SDAwgegvEAGIPEDPSL-KERASRILGLPIRELDLGVSPnkcnSDPGGPNE---- 591
XP_851155    506 PSPCQKLLPSSRPSHQLGGGRg--FEA-----EGGKPADSSL-EERASRILGLPVGEVNLRDAP----AQPGSPERsalg 573
Q80TS7       507 PSVCQKRLLSSRVLNQPSEGRe--CEA-----EVGQQGDSSL-EERSSSGLGFPVGEVNPRDAP----TQPGSQEHptlg 574 house mouse
XP_003475864 508 SSACQKLLLSSRVLHQPSGEPr--CEA-----EGGKAEDSSHgGARGPHLWDSRAGEVHVPCAA----AQPASPEHaasg 576 domestic guinea...
XP_008254630 489 PFRVPRPQLVS-LSHRPGEGSegeGEA-----EGGKPGDSSSlEERASRILGLPVGEVNLRGAP----AQSGRPEHpalg 558 rabbit
XP_004053111 576 pAASGAQGRAEGSE-VAMVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA-EELSVHSGSSDGSDTEAPGAS 653
XP_003772402 592 -TAARCADVARDSEpAPRVLRPAGPGRARDPGPYAGALREAVSRIRRHTAPDSDSDEA-PECGARSCSSEGSDTEASGTS 669
XP_851155    574 pAASGGAAPAEGPEgVAAAPRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA-AELSVQSGSSDGSDTEASGAS 652
Q80TS7       575 pAAPVCAGSLKGSE-AAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA-EDLSVHSGSSDGSDTDAPGAS 652 house mouse
XP_003475864 577 aAAPADAGSVRGSK-VTAAPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEGeEELSVHSGSSDGSDTEAPGAS 655 domestic guinea...
XP_008254630 559 pAAPAGAGCARGSG-GAAGPRRAGGGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA-EELSAHSGSSDGSDTEAPRAS 636 rabbit
XP_004053111 654 WRNERTLPGVGNSSPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQANRK 710
XP_003772402 670 RQPEQSLPGTSGDQGEAGRRAGELRDCIREILDVICQTEEALFRAEGSAQGKQGGGH 726
XP_851155    653 WRKEPPRPG-------DGGKTAELSDSVRDILEVISRPEESLFGTRDSKGVPQGNRE 702
Q80TS7       653 WRNERTLPALGNTRPREGGKTAGLSDSIREIVDVISQTEEG-FIREDTRKTPQGNRE 708 house mouse
XP_003475864 656 WWSERTPPETGGTSPGEGGKTAELKavsgrl-------------------------- 686 domestic guinea pig
XP_008254630 637 WRNEMTQPAAGNPGPQEGGKRTEMSDSFRELLGAVSQTEEALFGARDPAETPQADRE 693 rabbit
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