Conserved Protein Domain Family
Ctr
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pfam04145: Ctr 
Ctr copper transporter family
The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.
Links
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Statistics
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PSSM-Id: 461194
Aligned: 411 rows
Threshold Bit Score: 35.7465
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006676355 290 MYFHF-GYSDY-ILFDSWVPRSTFSYALGCLFCFLLAIGYEFLLvvgsGLDTAWKMVEssrHsndvglgDTLELPMSGSD 367
XP_015791703  68 NYFHI-TFGDT-VLFKGWSLQSTTDVLIACTVFFLLAIFYEGLKslreFL-------------------------FRREA 120
XP_015791719  68 SYFHT-TLGDT-LLFKSWVLDSSSRTIVACIVFFLMALLYEGLKsyreFL-------------------------FTRVA 120
ESN95093      14 NYFHT-RLRNV-ILFQGWETYNAPDVVLACVFAFVVAIIFEVVQsvkeCYAKKCYKWKlieRterfkdeSNDYGGVDRAQ 91 
EFX67187      23 MYFYA-DYKAV-VLFQGWDIQTVGAMVGSCIGIFLMGILYEGLKyfreYL-------------------------SSKHY 75 
2_pfamImport   1 MYFNF-NLPVT-VLFYEWEIKDSGALIGSCVGVAGIGILYELLKymrqQW-------------------------AKKMY 53 
EFA76788      19 SFFHW-DFLGQaILFKGWVTNNVGIYVLTLFVMFGMAVFSEFFTsyrhSL-------------------------NYNAT 72 
6_pfamImport   1 MTFTN-KLPFF-LLLKSIEITTYMDLTIACFTLFLVGFIYESLKtvrlRIATMTSCPVsccGcqeqrdvSAKSDVNGLVA 78 
XP_002122602  21 MTFTN-QLPFF-LLLKSIEIRNNMELAIAGFIMFLLGVFYEFLKhyrlCLASMTTCPVsccScneqhsdIKESKSNESIV 98 
XP_002128630   3 EYFSWwNLPLE-FLFDAWKISNAVGLLFTCIAVFCVALIFEGFRilsaILSSRFFVLPlvpCnrdddssSSSINGSVEIT 81 

XP_006676355 368 HSFGLYRSPMENPNISVLsddtpllrprsritgkrrtslnisthpklqpnhesqnlplcpttdltdqidmgpdgeeesvf 447
XP_015791703 121 RSGSYQVSLYTPTNA----------------------------------------------------------------- 135
XP_015791719 121 SKRCYSVSVINT-------------------------------------------------------------------- 132
ESN95093      92 TESTK--------------------------------------------------------------------------- 96 
EFX67187      76 TSVTYNNVKTPG-------------------------------------------------------------------- 87 
2_pfamImport  54 ANKVRSFVPST--------------------------------------------------------------------- 64 
EFA76788      73 DNPETTPLINDTE------------------------------------------------------------------- 85 
6_pfamImport  79 LTKLITKQPQQNGNGMNGndgsggkdg----------------------------------------------------- 105
XP_002122602  99 RTKLVVKQPIRNGLPKIDdsrmd--------------------------------------------------------- 121
XP_002128630  82 DSLN---------------------------------------------------------------------------- 85 

XP_006676355 448 dhsmsessshihqrvishgntsqaaglsdflqhhsgdiShhsnqhTPTQYLSRLYTKKWTHLQMR-----------IGRA 516
XP_015791703 136 ---------------------------------------------CPDDMIATSVNQSDEHPTPTlincsmwskahFYQS 170
XP_015791719 133 -----------------------------------------------GSNGCPENCGDGKPPARNvvtcrmwswahFYQS 165
ESN95093      97 -------------------------------------------------------ACSSPFTRSN-----------LIKT 110
EFX67187      88 ------------------------------------------------EAGSETSSQVNRTPMSFktsvt--sashYIQT 117
2_pfamImport  65 ------------------------------------------------SDCCQEDDDLECYTISYkspkf--wlfhVVQT 94 
EFA76788      86 ----------------------------------------------EVSKKTSDLRKNWNKFSATh----------YWKT 109
6_pfamImport 106 -----------------------------rdgrngfhdTev---rISNDKQTGPRSKQKSAVAIH-----------LIEV 142
XP_002122602 122 ----------------------------------tevrIk-----KEKQREDSSPIPHGTLVTIH-----------LIET 151
XP_002128630  86 -------------------------------------------------------HVKWERTKNH-----------ILQT 99 

XP_006676355 517 LIRLVTITLAYICMLLVMSFNVGLFLSVVVGLAVGKFMW 555
XP_015791703 171 SLHAIQVTISYTLMLGFMTFNTWICLSILLGAGLGYFLF 209
XP_015791719 166 LLHVLQVIASYTLMLGFMSYNIWICLAIALGAGHGYFLF 204
ESN95093     111 ILYTIHSSLGILIMLIYMTFNTYLCLAIILGKAVGFFFL 149
EFX67187     118 ALHLLQMIISYLLMLIVMTYNVWLFMAVVLGCTVGYFFF 156
2_pfamImport  95 ILHMVQVAIAYFLMLIVMAYNVWLAISVVAGAGVGYFIT 133
EFA76788     110 FCHIVQYVVNYFIMLVVMTFNAGLALAILGGIATGYFIF 148
6_pfamImport 143 LVHGAQLFVSYIIMLAVMTYNVCIVASVICGCMTGYLVC 181
XP_002122602 152 LVHGVQLLVSYVIMLSVMTYNVSIVICILAGCMVGYFTS 190
XP_002128630 100 AIHVFKVAASYGLMLAVMSYNAYIAISVLLGATLGYFVF 138
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