Conserved Protein Domain Family
MIX23

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pfam09774: MIX23 
Intermembrane space protein MIX23
Intermembrane space protein MIX23 regulates or stabilizes the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is compromised. MIX23, also known as Caffeine-induced death protein 2 (Cid2), is evolutionarily conserved and a homolog of the human protein CCDC58.
Statistics
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PSSM-Id: 430815
Aligned: 77 rows
Threshold Bit Score: 83.2357
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT01037     426 CFSTVVLRDFLRASRAIDDTITQHLNALVTPAR-AGFDPSSTAHrassysaypp--ssaslsagpPPAACRAFRDALLFP 502
GAC74617      54 CLAIGEFKELLRQYRQLDDGITTRLNRSFARSRaLGQSSSPSLLssstnsassv-dlgtstyatpQPAACAAFWRE-LVD 131
CCF54518      78 CIAIGEFKELLRQYRQLDDGISTRLNRSFARSRaLGQSASPSLLssssmnsasssdlgtstyatpAPGACAAFWRQ-LVD 156
XP_012190518  64 CLAISEFKDLLRQYRQLDDGITTRLNRSFARSRaLGQSTSPSLLssskmnsassmdlgtstygtpAPGACAAFWRE-LVD 142
XP_011387226  62 CLAIREFKELLRQYRQLDDGITTRLNRSFARSRaLGESTSPSLLsssktnsassidlgtstygtpAPGACAAFWRE-LVD 140
KDE03458      39 CSNLSAFKALLRSSRALDDSIALRLNRASALHRsfa---------------------------npDGDSCDSFWNE-LTT 90 
XP_004996476   5 CDDFAEFKRLLLEMRDTDDKIIYKMNTIiptksn--------------------------vdhldATSNCAALYHE-LNS 57 
EKD05569      38 CFNLSVFKGVVRQYRKLDDQVVTRLNRAQAQLRdEVRQGKGDS----------------------PDGMCAKMWAE-MMT 94 
EGG10773      49 CGDLSEFRKYIGRYRKLDDSLTLHLNRISIPTQsNTNSNQAKE----------------------ATIECSQFW-GILTQ 105
OAV96683      55 CSNISEFRRQLQRFRKLDDSITVSPNRSFVLLGsSDYHHRMSQTq-------------------tSPSQCAEFW-KILTA 114
ERT01037     503 AWQARDDLIQYCSRVADdavakda--eaaaqaAAQAAAAAAAsgtlvdgdyatpppplpppaeITERID----------- 569
GAC74617     132 VWIGREEVVRFCIKVADqt-----------ssPAPAVGST------------------------DHRLNady-------t 169
CCF54518     157 VWIGREEVVRFCIKVADqn------------nPSSSTQNNTApgs-----------------skDRLLDadyhpssapas 207
XP_012190518 143 VWIGREEVVRFCIQVADqa-----------snPTRSAAVNAGa---------------------DSLLDadf------rp 184
XP_011387226 141 VWIGREEVVRFCIKVADqh-----------arPAPTPLLSTSds-------------------tDRLLDadyhp---tsa 187
KDE03458      91 RWNERTRVLAFCDQVHLdq-----------arTLPIPTADSTr--------------------IEKGLD----------- 128
XP_004996476  58 AHMQRRQSMERCLTQVQqei-----------------------------------------rdLKTQLNvgdr-----dm 91 
EKD05569      95 GWLNRQKLLTYCQNTVAqnlkiaqaaqaeqaqVAAVPASHDTap-----------------------------------t 139
EGG10773     106 TWLNRESVIRSCIDILErslkvks--dsierpSLDTSEKGPNe------------------------------------- 146
OAV96683     115 SWLSREKLIRSCIEVVDrsvlern--qsiqrlSNPVDLSSQStqdtt------------------------------asn 162
ERT01037     570 -PYIKRKQYALVEPQ---ANLLASLMRNEKGVESIVRARSWDVLQARCGG 615
GAC74617     170 pPSGKQDRWSRAENT---AETLNRQLHNELKVESIIRARSLDAFKSRCKF 216
CCF54518     208 vVNAGEQRWSRAENS---AETLARQLHNELKVESIIRARSLDEFKSRCKF 254
XP_012190518 185 kQENKTEKWSRAENT---SETLARQLHNELKVESIIRARSLDAFKSRCKF 231
XP_011387226 188 sQSRPENRWSRAENT---SETLARQLHNELSVESIIRARSLDAFKSRCKF 234
KDE03458     129 -----RDRLTTQGRGeteVEVERRQLRTETNVEAIIRARSLDLFLSRCPY 173
XP_004996476  92 rAEQGKGKTSLEGQAlreKQALSRQIRRELVAEDILQEQTKKVFKDRCGR 141
EKD05569     140 wGHAGKDGAYPRGVSe--NQVLADQLANEATVEAIVRKRTLEVFKTRCPF 187
EGG10773     147 -TLEKSQRKRAIESElynERLKLKMIYDELNVESLIRQQSMKKFKSRCSA 195
OAV96683     163 kQKISSKEKSQLEAEvytAELKRRMVHDELAVESAIRKQTLQKFRARCSE 212
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