Conserved Protein Domain Family
LLC1

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pfam14945: LLC1 
Normal lung function maintenance, Low in Lung Cancer 1 protein
This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis.
Statistics
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PSSM-Id: 464392
Aligned: 18 rows
Threshold Bit Score: 157.505
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005327137  16 LVAQDEIWKYRLKAESEARKNWPQNWGFLTTPVE-ELIEGEEE-S--------RTPKPK---------IQLPERFHIRQM 76 
XP_001510867  14 FVAQDQIWRCHIKTELEAAKKWPHKWGFLTPPFE-KLVKHESE-E--------PLPKPE---------IMPQEHLQVQPV 74 
XP_002123910  16 FVANDEIWKSHVHMEWAASKKWPQNWGFMTQTYK-ELSADAGPsK--------KEEKPK---------VELPEQLRLAPI 77 
XP_782490     18 FVANDQVWKDHIRYEETASKRWPEYWGFLGGSYK-DLVKDDFV----------KRDVKK---------IELPPPLVLPPI 77 
EDV25936      10 FVHRNQIWSDHILAERGAAKRWPETWGFLTGGGFkALIDDEREkR--------RKEMEKkghaggidvVKLP-------- 73 
XP_001626623  12 FVHQDQIWKDHIGHEHGAAKHWPENWGFLIEQYK-QLANEDNNiEngeaavrvKQRREN---------LKLP------PI 75 
XP_014342476  17 FVAEDEIWKSHVNAENEAAKRWPRSWGFLSTPYH-KLVEDVS-----------KKTESK---------IEYPKHLQIQPA 75 
XP_015220506  16 FVAQDQIWKCHVNMELEAAKVWPSKWGFLTMSYH-EMLQDQTL----------KKEGVK---------LELPEHLQTRPT 75 
XP_417493     67 AVAEDSCWKRYVESELETARRWSHKWGFLKAALE-ELIEDEKK----------EKTKPT---------IQLPEHLRIRPV 126
XP_008113440   9 FVAEAQIWKDHIETEREAARRWPSRWGFLLTSVE-ELLKDEEK----------QPPKPK---------IPLPQHLQIRPV 68 
XP_005327137  77 -TPVEKYIKVLPSP-PVPQTSQGFIGWRSAVPGLNknLQLDfEI---RSCKGVYARELGWPKQG 135
XP_001510867  75 -IPVEKYIKISPSP-PIPKTTQGFIGWRSTVPGLE--LDHYyQI---RSCKGAFSKQLNWPAEG 131
XP_002123910  78 -TPIEKYIKIGESP-PYPDTTTGLVGWRSTKPDCK--LEIYgAY---AKGKGGLVKQLNWPQEG 134
XP_782490     78 -TPISRYIKVDTSPkPFPKTTAGKIGWRSSETQHS--LEIYgKY---ARPKGGLIRQLNWPPEG 135
EDV25936      74 --PIQNKVQSKSAK-PFPKTTSQEVGHRSTQGQCN--LEIYgRYapnARGYGGLSKMLKWPPEA 132
XP_001626623  76 dSSVASQLSVGRSKaRYPSTTASEIGWRSSQRQCN--LERYgRY---TKQKSSFLGQMKWPPEA 134
XP_014342476  76 -TPIEKYIHVKPSP-AVPKTTQGFIGWRSTVSGLE--LERYgRT---TIGKSSFFKEMKWPLES 132
XP_015220506  76 -TSPEKYFQVGASP-AVPPTTQGLIGWRSTVPELQ--LERFgKV---HHGKSSFLKELGWPGDA 132
XP_417493    127 -TPVEKYIKVNPSP-PVPKTSQGFIGWRSAVPELQ--LEHCfQI---QSCKGAFFKDLKWPREP 183
XP_008113440  69 -TPVEKYIKIHPSP-PVPQTTQGFIGWRSTVPGLE--LERYyQI---RSNKGAFYKDLKWPNEP 125
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