1VAX,4MB8,1J2G


Conserved Protein Domain Family
urate_oxi
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TIGR03383: urate_oxi 
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urate oxidase
Members of this protein family are urate oxidase, also called uricase. This protein contains two copies of the domain described by the uricase model pfam01014. In animals, this enzyme has been lost from primates and birds. [Central intermediary metabolism, Other]
Links
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Statistics
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PSSM-Id: 274554
Aligned: 35 rows
Threshold Bit Score: 334.163
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VAX_A         4 VLGQNQYGKAEVRLVKVTRNTAR--------------HEIQDLNVTSQLRG-DFEAAHTAGDNAHVVATDTQKNTVYAFA 68  Arthrobacter gl...
O32141       171 MKRTMSYGKGNVFAYRTYLKPLTgvkqipessfagrdNTVVGVDVTCEIGGeAFLPSFTDGDNTLVVATDSMKNFIQRHL 250 Bacillus subtil...
BAB18099       3 SVTAARYGKDNVRLFKTHRDPNTg------------vHSVTETVVCVLLEG-DIESSYTRADNSVVVATDSMKNTVFVLA 69  Isaria tenuipes
XP_001221643   3 GLASARYGKDNVRVCKVQRDEQTg------------vHTVTEMTVCCLLEG-KIETSYTEADNSVVVATDSIKNTIYIKA 69  Chaetomium glob...
BAB18096       3 YVSVARYGKDNVRVLKVSRDAGTg------------vQTVAEMTIRCLIEG-DIEASYTGADNSSVVATDSIKNTIYILA 69  Cerataphis fran...
P33282         3 TVAAARYGKDNVRVYKVHKDPKTg------------vQTVTEMTVCVLLEG-EIDTSYTKADNSVIVATDSIKNTIFILA 69  Aspergillus nid...
XP_001244903   4 TLAAARYGKENVKVCKVHRDTTTg------------wQTVTEMTVSVLLEG-DIESSYTKADNSVVVATDSMKNTIYILA 70  Coccidioides im...
O74409         6 YVKQCAYGKTLVRFMKKDICPKTk------------tHTVYEMDVQSLLTG-ELEESYTKADNSIVVPTDTQKNTIYVFA 72  Schizosaccharom...
Q45697       175 KERVMYYGKGDVFAYRTYLKPLTgvrtipespfsgrdHILFGVNVKISVGGtKLLTSFTKGDNSLVVATDSMKNFIQKHL 254 Bacillus sp. TB-90
1J2G_A         5 keRVMYYGKGDVFAYRTYLKPLTgvrtipespfsgrdHILFGVNVKISVGGtKLLTSFTKGDNSLVVATDSMKNFIQKHL 84  Bacillus sp. TB-90

1VAX_A        69 RD-GFATTEEFLLRLGKHFTEGFDWVTGGRWAAQQFFWDRI------N--D---HDHAFSRNKSEVRTAVLEISGS-E-- 133 Arthrobacter gl...
O32141       251 ASyEGTTTEGFLHYVAHRFLDTYSHMDTITLTGEDIPFEAMpay-eeK--ElstSRLVFRRSRNERSRSVLKAERS-Gn- 325 Bacillus subtil...
BAB18099      70 KQhPVTPPELFAATVGAHFVDTYPHIHVAAVRVVTTRWARIrv--dgR--P---HPHSFVKESEEKRTVAARASRR-Ag- 140 Isaria tenuipes
XP_001221643  70 KEhPVNPPEVYASHLGQHFLDTYPHITVAHVDVVVHRWTRMai--dgA--P---HPHSFFRDGQETRNVKATVARG-Ag- 140 Chaetomium glob...
BAB18096      70 KQhRVHPPELFASILSTHFIQKYSHIHVADVDIVTHRWLRMdi--dgK--P---HPHSFIKDAGETRNVHVHAKRQ-Dg- 140 Cerataphis fran...
P33282        70 KQnPVTPPELFGSILGTHFINKYKHIHVAHTNIITHRWTRLni--dgK--P---HSHSFVRDSEETRNVQVDVTEG-Vg- 140 Aspergillus nid...
XP_001244903  71 KQhPVTSPELFASIIGSHFIEAYKHIHAAHVHIVAHRWTRMai--dgK--L---HPHSFMRDGTDVRIADADVIEG-Kg- 141 Coccidioides im...
O74409        73 KNnDVSVPEVFAAKLAKHFVDKYKHIHGAALDITITPWTRMev--qgK--P---HSHSFIRNPGETRKTHVVFSEG-Kg- 143 Schizosaccharom...
Q45697       255 ASyTGTTIEGFLEYVATSFLKKYSHIEKISLIGEEIPFETTfav-knG--NraaSELVFKKSRNEYATAYLNMVRNeDn- 330 Bacillus sp. TB-90
1J2G_A        85 ASyTGTTIEGFLEYVATSFLKKYSHIEKISLIGEEIPFETTfavkngNraA---SELVFKKSRNEYATAYLNMVRN-Edn 160 Bacillus sp. TB-90

1VAX_A       134 -QAIV---AGIEGLTVLKSTGSEFHGFPRDKYTTLQETTDRILATDVSARWRYN-------TVEV---D---FDAVyASV 196 Arthrobacter gl...
O32141       326 tITITeqySEIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYEnt---ndSYAS---DparYVAA-EQV 398 Bacillus subtil...
BAB18099     141 -IAIN---SGIADLTVLKSTGSAFHGFIRDEFTTLPETWDRIMSTDVDASWDWAvfp-dlaAVRA---AatrFDAAhEAA 212 Isaria tenuipes
XP_001221643 141 -IDLN---SSIAGLSVLKSTGSGFHGFVRDEFTTLPETWDRILSTDIDCSWAWKrfp-naaAVQQ---GaerFDKAwESA 212 Chaetomium glob...
BAB18096     141 -IAIA---SSIVGLSLLKSTGSAFSGFVRDEFTTLPESWDRILATDVDASWKWSkfa-dleAVEQ---SaakFDAAwESA 212 Cerataphis fran...
P33282       141 -IDIK---SSINKLTVLKSTGSQFWGFVRDEYTTLPEVWDRILSTDVEATWAWKrfs-gldEVRG---NvpkFDETwEAA 212 Aspergillus nid...
XP_001244903 142 -IEIK---SSISGLLLLKSTGSQFHGFIQDEFTTLPETWDRILSTEIDANWTWMpfe-nldHVKS---VvpkFDRAfSSA 213 Coccidioides im...
O74409       144 -FDVV---SSLKDVLVLKSTGSGFTNFHKCEFTTLPEVTDRIFSTSIDCNYTFKhfdtfeeLAGF---D---FNSIyEKV 213 Schizosaccharom...
Q45697       331 tLNITeqqSGLAGLQLIKVSGNSFVGFIRDEYTTLPEDSNRPLFVYLNIKWKYKnt---edSFGT---NpenYVAA-EQI 403 Bacillus sp. TB-90
1J2G_A       161 tLNITeqqSGLAGLQLIKVSGNSFVGFIRDEYTTLPEDSNRPLFVYLNIKWKYKnt---edSFGTnpeN---YVAA-EQI 233 Bacillus sp. TB-90

1VAX_A       197 RGLLLKAFAETHSLALQQTMYEMGRAVIETHPEIDEIKMSLPNKHHFLVDLQ-PFGQDn---pNEVFYAADRPYGLIEAT 272 Arthrobacter gl...
O32141       399 RDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE-IPGSK-----GKVYTEPRPPYGFQHFT 472 Bacillus subtil...
BAB18099     213 RDITLRRFANDNSASVQATMYKMSEDILAAVPQVSKVYYSLPNKHYFELDLSwHKGIKntgkdAEVYVPQSNPNGLIKVE 292 Isaria tenuipes
XP_001221643 213 RGIIMKTFAIDESASVQNTMYKMCEQILEAVPEVDKAGFALPNKHYFEIDLSwHKGIKntgkdAEVYAPQSGPNGLIKCE 292 Chaetomium glob...
BAB18096     213 RCITLEMFAQDDSPSVQNTMYKMCQRILNAIPDTQSVAYVLPNKHNFELDLSwHGGIQntgkqAEIYVPQTCPNGLIKCE 292 Cerataphis fran...
P33282       213 RNITLKTFAEEESASVQATMYKMGEQILAYQPLLETVEYSLPNKHYFEIDLSwHKGLKntgkdAEVFVPQTNPNGLIKCT 292 Aspergillus nid...
XP_001244903 214 RDISLRLFAQDDSASVQNTMYKMASEILGTEPLLKAVSYSLPNKHYLELGLSwHKGLKnvgkdAEVYVPTSAPNGLIQCT 293 Coccidioides im...
O74409       214 KEITLETFALDDSESVQATMYKMADTIINTYPAINEVYYALPNKHYFEINLA-PFNIDnlgsnCSLYQPQAYPSGYITCT 292 Schizosaccharom...
Q45697       404 RDIATSVFHETETLSIQHLIYLIGRRILERFPQLQEVYFESQNHTWDKIVEE-IPESE-----GKVYTEPRPPYGFQCFT 477 Bacillus sp. TB-90
1J2G_A       234 RDIATSVFHETETLSIQHLIYLIGRRILERFPQLQEVYFESQNHTWDKIVEE-IPESE-----GKVYTEPRPPYGFQCFT 307 Bacillus sp. TB-90

1VAX_A       273 IQR 275 Arthrobacter globiformis
O32141       473 VTR 475 Bacillus subtilis subsp. subtilis str. 168
BAB18099     293 VSR 295 Isaria tenuipes
XP_001221643 293 VFR 295 Chaetomium globosum CBS 148.51
BAB18096     293 VSR 295 Cerataphis fransseni yeast-like symbiont
P33282       293 VGR 295 Aspergillus nidulans FGSC A4
XP_001244903 294 VAR 296 Coccidioides immitis RS
O74409       293 VAR 295 Schizosaccharomyces pombe 972h-
Q45697       478 VTQ 480 Bacillus sp. TB-90
1J2G_A       308 VTQ 310 Bacillus sp. TB-90
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