Conserved Protein Domain Family
GDPD_GDE4
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cd08612: GDPD_GDE4 
Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins
This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in mammalian GDE4 (also known as glycerophosphodiester phosphodiesterase domain-containing protein 1 (GDPD1)) and similar proteins. Mammalian GDE4 is a transmembrane protein whose cellular function has not yet been elucidated. It is expressed widely, including in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocytes. It is also expressed in the growth cones in neuroblastoma Neuro2a cells, which suggests GDE4 may play some distinct role from other members of the GDE family.
Links
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Statistics
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PSSM-Id: 176553
Aligned: 23 rows
Threshold Bit Score: 353.829
Created: 25-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:catalytic site [active site]
Evidence:
  • Comment:The catalytic mechanism of glycerophosphodiester phosphodiesterases is based on the metal ion-dependent general acid-base reaction.
  • Comment:Based on structure evidence and site-directed mutagenesis of Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase, the catalytic site consists of two conserved histidine residues which serve as general acid and general base in catalyzing the hydrolysis of the 3'-5' phosphodiester bond.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         #                               
Q8N9F7                         14 GGYLVTSFLLLKy-------PTLLHQRKKq----------rFLSKHISHRGGAGENLENTMAAFQHAVKI-GTDMLELDC 75  human...
WGS:AAGF:cds.TTHERM_00957590A   8 TVYWATSYFFLKn-------PQILKKKKSwkspllskalnkEQVLHIAHRGGSRYKVENTIESFENGLKE-GTNVLELDV 79  Tetrahymena thermophila SB210...
XP_001470251                   12 GAYIAVSVCLLQmavrskkqKSLLEKKFS------------YPITKIAHRGGSLLGPENTMYTFMQAAKVgLCDMIELDV 79  Leishmania infantum JPCM5...
EEE25482                       28 TCFVAASWVLNRw-------PGLLWQTKRif---------sNPPRNIAHRGGQAERAENTILAFSYAVNDcKCRMIELDV 91  Toxoplasma gondii GT1...
XP_806230                      13 GGYIMGAGILVRv------fPLRLGAEREllke-----rfpYPVTKIAHRGGSLIGPENTIYTFGRAISVgNADMLELDV 81  Trypanosoma cruzi strain CL Brener...
CAX74799                       10 ATYSLTSYILLRq-------PTILHRKKRf----------pFKASHISHRGGSGEKIENTLEAFSSSFLV-GTHMFETDC 71  Schistosoma japonicum...
XP_001433515                    9 IGYWALSLTFFVfpy--kkkNVFRHSKYQkyl-------qrKSILHISHRGGCRENLENTMQAFQHAYDL-GTDCLEMDL 78  Paramecium tetraurelia strain d4-2...
XP_002139421                   18 TIYYVASSFFLRyptllpfiKFELRRRKKsgil-----gkgNGCLHISHRGGSEERPENTQMAFEHAILNcCTDMIETDV 92  Cryptosporidium muris RN66...
XP_626009                      23 VIILIVNYLLLHfpkilraiNGSNSKLKSsnsv----lgkgKGCLHISHRGGSEEVPENTTVAFDHAINNcSTDMLEIDV 98  Cryptosporidium parvum Iowa II...
Q7L5L3                         13 GSYAMLSIFFLRr-------PHLLHTPRAp----------tFRIRLGAHRGGSGELLENTMEAMENSMAQ-RSDLLELDC 74  human...

Feature 1                                     #                                                                   
Q8N9F7                         76 HITK-DEQVVVSHDENLKRATGVNv-------nISDLKYCELPPYlg---------kLDVSFQRAcq-----------ce 127 human...
WGS:AAGF:cds.TTHERM_00957590A  80 CMTK-DKQIIVIHDDNLKRMCGVNk-------lTEEFDYKDLPKFqee-------ihLDFSVGGKvys----------kd 134 Tetrahymena thermophila SB210...
XP_001470251                   80 RESK-DGQIVVCHDRTLERTCGPKyag----vtISELVVGKNPSKtlpq----ckrtIELEFATRdikqyea--sdsvpv 148 Leishmania infantum JPCM5...
EEE25482                       92 WMTK-DKVMVVAHDDNIERVTGQNm-------lISETNYADLPPV------------LDSDHLKDchmefvpgfkgfpvk 151 Toxoplasma gondii GT1...
XP_806230                      82 RQSR-DGEIVVSHDAALLRTCGSFhegtnvvdiVVDGNPNKNLPQsl--------reIPIHFESPqrggcyk-atdsvpv 151 Trypanosoma cruzi strain CL Brener...
CAX74799                       72 HLTK-DNQVVVFHDNELYRCTGVSg-------lVKEFSYDDLPRYlk---------vIEVQFTPGsfcn--------des 126 Schistosoma japonicum...
XP_001433515                   79 CMTKdKKQIVVLHDSSLLRMCGVQa-------hVKEYNYADLPKFle---------rVRLDFAPNdyis--------tst 134 Paramecium tetraurelia strain d4-2...
XP_002139421                   93 WLTK-ENELIVLHDNHLGNICGVDk-------yVGDLLYNEMPLTldsdtlcpsseyLDISKWRGfp-----------ik 153 Cryptosporidium muris RN66...
XP_626009                      99 WLTK-DNLLVVLHDENLLNICNIDk-------lVGEFNYADLPMTkd---------sESLTPSSDflnrnew--kcypkk 159 Cryptosporidium parvum Iowa II...
Q7L5L3                         75 QLTR-DRVVVVSHDENLCRQSGLNr-------dVGSLDFEDLPLYke---------kLEVYFSPGhf-----------ah 126 human...

Feature 1                                                                                                         
Q8N9F7                        128 GKDNRIPLLKEVFEAFPNTPINIDIKVNNNv-LIKKVSELVKRYNREHLTVWGNANy----------EIVEKCYKEN--- 193 human...
WGS:AAGF:cds.TTHERM_00957590A 135 YKNPYIPTLDEVFTRFPGVHMNIEIKTPNEe-FIQMMNKLIIKHNREDITIWGCKNp----------EMSRRLKEVN--- 200 Tetrahymena thermophila SB210...
XP_001470251                  149 DDTTRICLLSEVLKKFPSMPLHIDIKDESKd-FVALVLNLLAAHGRESITFVGSSRpk-------nrQFINEYFAERep- 219 Leishmania infantum JPCM5...
EEE25482                      152 FSPQPLPRLEDVFAEFPDTIMNVDIKAEADpqSVSKTLDLVRKYNRVDKTVFGSFD-----------QRTLKLIQEYe-- 218 Toxoplasma gondii GT1...
XP_806230                     152 DETTRLCLLSEVFDVFPDVPLHIDIKSEGAe-ITKKVLKLVERYGRETKTLVGTSNwrn------rkHIYDYFVSEHl-- 222 Trypanosoma cruzi strain CL Brener...
CAX74799                      127 SPSCKIARLEDLFDKFPNTPVNIDIKVHNDf-LINEVARLIETHSRERITVWGSMNs----------KVSKECKLRN--- 192 Schistosoma japonicum...
XP_001433515                  135 CKTAYLPLFEDVLKKFPDVLLNIEIKTPDPe-VVQIVNDLILKYQRQDTIIWGARF-----------QKQNELLKSIn-- 200 Paramecium tetraurelia strain d4-2...
XP_002139421                  154 FQGQRILTLETLFQIFPNIRMSIDIKNPNSlvAVERTVEIIRKYKREDLTVIASFShsnikylrkinNSVVRIHSENnee 233 Cryptosporidium muris RN66...
XP_626009                     160 FSSQKLITLEELFQRYPDTLISVDVKNPDSrlAVSKTVGLVRRFKRENKTMLCSFSn----------ENIDYLNEYNknk 229 Cryptosporidium parvum Iowa II...
Q7L5L3                        127 GSDRRMVRLEDLFQRFPRTPMSVEIKGKNEe-LIREIAGLVRRYDRNEITIWASEKs----------SVMKKCKAAN--- 192 human...

Feature 1                                                                                                         
Q8N9F7                        194 ---SDIPILFSLQRVLLILG------LFFTGLLPFVPIREqFFEIPMPSIILKLKEPht---------------msRSQK 249 human...
WGS:AAGF:cds.TTHERM_00957590A 201 ---PNINRFFSLGGLKDLVI------KYFTGLLPFSEIQEeSLQIPIFNREHYEWKKlesk-----------gfmqHLAC 260 Tetrahymena thermophila SB210...
XP_001470251                  220 -eiRKRYRIFGGPRDFFQTYl-----LFYTGLLPYFSVNYdVFSIPVFTSTMKNDAA-------------------REYG 274 Leishmania infantum JPCM5...
EEE25482                      219 ---KDAVISIGPTRAKLLVF------AYYTGLMPFLPIPErVWEFPVCKYYFLSWLGkstgkwesrlpwfcagfvkGLCY 289 Toxoplasma gondii GT1...
XP_806230                     223 --sESERLLKKRKRFRIFAGpmdcfvVYVAYFLGVLPLVPlAFDVFSIPVFTKCKMK-------------------ALGS 281 Trypanosoma cruzi strain CL Brener...
CAX74799                      193 ---KNILTFAPFSYVIWIMA------CYFIGLLPFLPVKYdCFELPLVSVIRSNEFA-------------------RQRR 244 Schistosoma japonicum...
XP_001433515                  201 ---PAIPRFFTVEGILKVYF------LYLTGLLPFFDIPDdSMQAPMYTDDFYQWKLqvan-----------stseKIQQ 260 Paramecium tetraurelia strain d4-2...
XP_002139421                  234 nfrSKLILGASQTTVIYLLL------AYFIGILPFISINEdIYSFPLSYIFFCKYGYtvskls--------flgsnITNY 299 Cryptosporidium muris RN66...
XP_626009                     230 -nePELVICIGKDKLLKILL------AYFTGFLPWIHIEEhVLSFPMSYIFFSTYGRkfadk---------iskyfKLSK 293 Cryptosporidium parvum Iowa II...
Q7L5L3                        193 ---PEMPLSFTISRGFWVLL------SYYLGLLPFIPIPEkFFFCFLPNIINRTYFPfs---------------csCLNQ 248 human...

Feature 1                                                                                                 
Q8N9F7                        250 FLIWLSDLLLM---------RKALFDHLTARGIQVYIWVLNEEQEYKRAFD-LGATGVMTDYPTKLRDFLHN 311 human
WGS:AAGF:cds.TTHERM_00957590A 261 RVYFLAIRLLLss-----fiAKPLFEHLRQRGILVIFWVMNNREMFEECLQfSGCVGIMTDEPALLTQFLKE 327 Tetrah...
XP_001470251                  275 RVVAAVGAFLFs--------SPLLWRYLQSRGVAVIGWNLNDEVDILQGIQ-WPLNGLMSDDPIKLRQLIDA 337 Leishm...
EEE25482                      290 LYAWTSFKLIT---------NPNFVAALKRRGLVTFGWVANTAEEFSDGYYrVGCDGLMTDRPALQAEWLCS 352 Toxopl...
XP_806230                     282 CFTRFIAYFVN---------SPVLWKHLQRRGILVLGWVLNDDEEFEEASN-WPINGIMSDDPIALDAFFRS 343 Trypan...
CAX74799                      245 WDRFLPNVALLfsey--llsSPLFIKHLRKRGIPVFFWVCNNEDDMLKAFE-LGASGVMTDYPKQLAEFLKK 313 Schist...
XP_001433515                  261 IHNFIWFLGLI---------SKPLFNHLHKRGIFVYYWVLNNEKEYERALK-TGCHGMMTDCPTVLKQYLIK 322 Parame...
XP_002139421                  300 IKLHLIPNILMwi-----fsRRLMIRHLQKRGIRCFAWVCNTEEEIERCCK-LGLDGIMTDKPTLLRDYYNR 365 Crypto...
XP_626009                     294 YQLKYIEDELVpnilvwlfsRKLLIRHLQKRGIRCFAWVCNNEKEMNICKE-LELDGIMSDRPNLLREYYIK 364 Crypto...
Q7L5L3                        249 LLAVVSKWLIM---------RKSLIRHLEERGVQVVFWCLNEESDFEAAFS-VGATGVITDYPTALRHYLDN 310 human

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