2XPY,1HS6


Conserved Protein Domain Family
leuko_A4_hydro

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TIGR02411: leuko_A4_hydro 
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leukotriene A-4 hydrolase/aminopeptidase
Members of this family represent a distinctive subset within the zinc metallopeptidase family M1 (pfam01433). The majority of the members of pfam01433 are aminopeptidases, but the sequences in this family for which the function is known are leukotriene A-4 hydrolase. A dual epoxide hydrolase and aminopeptidase activity at the same active site is indicated. The physiological substrate for aminopeptidase activity is not known.
Statistics
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PSSM-Id: 274120
Aligned: 8 rows
Threshold Bit Score: 1010.46
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XPY_A    18 DQSTLSNYK-DFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNksdeLHLDTSYLDVQEVHIDG----SKAD-FQIE 91  baker's yeast
CAG77619  44 DPSTLSNYE-HFKPTNTTVCLKVDWTDQKLAGSVTYDLTVENSPKN----LVLDTSYLDIQEVQVNG----HKAD-FSIG 113 Yarrowia lipolytica...
CAG85609  18 DPCSNSNYK-DFQVSNTELDISVSFDKKIVSGQVTYKLTAKTPNTTs---IVLDTSYLKIIKIRING----LPSDnYELV 89  Debaryomyces hansen...
O94544     6 DPSTQSNYH-DVSISKLDWHARIDFDQELLHGKVSFVIQSARVSQAls-hIILDTSYLEIKNVTIND----IPTP-FRVD 78  Schizosaccharomyces...
P09960     6 DTCSLASPAsVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRs---LVLDTKDLTIEKVVING----QEVK-YALG 77  human
AAK93169  79 DPSSYSQPD-LITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDk---ILLDVRDINVTNATLLAggseLPIN-FFIS 153 fruit fly
Q10740    57 DQSTLSNYK-DFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNksdeLHLDTSYLDVQEVHIDG----SKAD-FQIE 130 Saccharomyces cerev...
1HS6_A     6 DTCSLASPAsVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRs---LVLDTKDLTIEKVVING----QEVK-YALG 77  human
2XPY_A    92 QRKEPLGSRLVINNa---SCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGK-PYVFSQLEAIHARSLFPCFDTPSVKSTF 167 baker's yeast
CAG77619 114 ERHNIFGSPLTITLp--pNSGDKLQVKIAYSTTPSCTALQWLTPEQTAGKKaPYFFSQCQAIHARSVMPAFDTPSVKSTF 191 Yarrowia lipolytica...
CAG85609  90 KRKEPFGSPLKISLp--tTINKEFELNIEFSTTDKCTALQFIEKEATDGQTaPYLFSQCQAIHARSLFPCFDTPGIKSPY 167 Debaryomyces hansen...
O94544    79 KRRGFLGSALHIVPadeiPSSKSCILTILYSTTKDCTALQFLKPEQTIGGKfPYVFSECQAIHARSFIPCQDTPSVKVPC 158 Schizosaccharomyces...
P09960    78 ERQSYKGSPMEISLpialSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEhPYLFSQCQAIHCRAILPCQDTPSVKLTY 157 human
AAK93169 154 DAVDDIGQKLTLELpsgtAKG-SLNVRIDYETSSSASGLQWLNPTQTLGKEhPYMFSQCQAIHARSVIPCQDTPAVKFTY 232 fruit fly
Q10740   131 QRKEPLGSRLVINNa---SCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGK-PYVFSQLEAIHARSLFPCFDTPSVKSTF 206 Saccharomyces cerev...
1HS6_A    78 ERQSYKGSPMEISLpialSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEhPYLFSQCQAIHCRAILPCQDTPSVKLTY 157 human
2XPY_A   168 TASIESP--LPVVFSGIRIEdT--S--KDTNIYRFE--QKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEF 239 baker's yeast
CAG77619 192 DIEIESD--HPVVASGLPIK-S--S--NDTGKFVFR--QKVPIPAYLFALAGGDLDSAPIGPRSDVYSEPCDLHKCQYEF 262 Yarrowia lipolytica...
CAG85609 168 NMKVKSP--YACLMSGRPKE----T--NEEGVYCFH--QPIPIPSYLVALASGDLASAPIGPRSTVYSERVGLSDCQWEF 237 Debaryomyces hansen...
O94544   159 TFKIRSK--LPVIASGIPCGtAnfC--NGSLEYLFE--QKNPIPSYLFCILSGDLASTNIGPRSSVYTEPGNLLACKYEF 232 Schizosaccharomyces...
P09960   158 TAEVSVPkeLVALMSAIRDGeTpdP--EDPSRKIYKfiQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEF 235 human
AAK93169 233 DATVEHPseLTALMSALID-----K--KEPGKTLFK--QEVPIPAYLVAIAIGKLVSRPLGENSSVWAEEAIVDACAEEF 303 fruit fly
Q10740   207 TASIESP--LPVVFSGIRIEdT--S--KDTNIYRFE--QKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEF 278 Saccharomyces cerev...
1HS6_A   158 TAEVSVPkeLVALMSAIRDGeT--PdpEDPSRKIYKfiQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEF 235 human
2XPY_A   240 ENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNH 319 baker's yeast
CAG77619 263 EADTEKFINAAENIVFPYEWEKYDVLVLPPSFPYGGMENPNITFATPTLVSGDRQNVDVIAHELAHSWSGNLVTNCSWEH 342 Yarrowia lipolytica...
CAG85609 238 EKDMENFIQVAEGLIFKYEWLKFDALILPSSFPYGGMENPNITFATPTLISKDRSQVKVMAHELAHSWSGNLVTNCSWEH 317 Debaryomyces hansen...
O94544   233 EHDMENFMEAAEQLTLPYCWTRYDFVILPPSFPYGGMENPNATFATPTLIAGDRSNVNVIAHELAHSWSGNLVTNESWQC 312 Schizosaccharomyces...
P09960   236 S-ETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDH 314 human
AAK93169 304 S-ETATMLKTATELCGPYVWKQYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDKSLADVVAHEIAHSWTGNLVTNKNFEH 382 fruit fly
Q10740   279 ENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNH 358 Saccharomyces cerev...
1HS6_A   236 S-ETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDH 314 human
2XPY_A   320 FWLNEGWTVYLERRIIG---------------AIHGEPTRHFSALIGWSDLQNSIDS-MKdPE---RFSTLVQNLNDNt- 379 baker's yeast
CAG77619 343 FWLNEGWTVYLERRIVG---------------ALEGEQQRHFSAIIGWNALEESVKL-MSrDPvqeSYTQLVVDLKPNgg 406 Yarrowia lipolytica...
CAG85609 318 FWLNEGWTVYLERRIIGgiaaaeakslgekeaAQYGEKRRHFSAIVGWNSLVDSVKT-LD--P---KYTSLVWNLKEGs- 390 Debaryomyces hansen...
O94544   313 FWLNEGMTVFLERKILG---------------RLYGEPTRQFEAIIGWGELEESVKL-LGeDS---EYTKLIQNLEGR-- 371 Schizosaccharomyces...
P09960   315 FWLNEGHTVYLERHICG---------------RLFGEKFRHFNALGGWGELQNSVKT-FGeTH---PFTKLVVDLTDI-- 373 human
AAK93169 383 FWLNEGFTVFVESKIVG---------------RMQGAKELDFKMLSNLTDLQECIRTqLNkTP---ELTKLVVDLSNC-- 442 fruit fly
Q10740   359 FWLNEGWTVYLERRIIG---------------AIHGEPTRHFSALIGWSDLQNSIDS-MK-DPe--RFSTLVQNLNDNt- 418 Saccharomyces cerev...
1HS6_A   315 FWLNEGHTVYLERHICG---------------RLFGEKFRHFNALGGWGELQNSVKT-FGeTH---PFTKLVVDLTDI-- 373 human
2XPY_A   380 -DPDDAFSTVPYEKGFNLLFHLETILGgKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEIl---dSVDWETWL 455 baker's yeast
CAG77619 407 aDPDDAFSSVPYEKGSTFLFFLETEIG-QAKFDPFVKHYFKHFRYKSLDTYQFIDCLFDFYANDKEVtdklnAIDWEKTL 485 Yarrowia lipolytica...
CAG85609 391 -DPDDAFSRIPYEKGFNFLFYIEQQVGgIKEFDPFIPYYFKKFRYESLDTYQFIDVLYEFFEPRGKAak-ldAIDWKGWI 468 Debaryomyces hansen...
O94544   372 -DPDDAFSTVPYEKGSNFLYEIERVIGgPSVFEPFLPFYFRKFAKSTVNEVKFKHALYEYFSPLGLAsk-ldSIDWDTWY 449 Schizosaccharomyces...
P09960   374 -DPDVAYSSVPYEKGFALLFYLEQLLGgPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKD--KVdv-lnQVDWNAWL 449 human
AAK93169 443 -GPDDAFSSVPYIKGSTFLRYLEDLFGgPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKdk-lsAVDWDLWL 520 fruit fly
Q10740   419 -DPDDAFSTVPYEKGFNLLFHLETILGgKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEIl---dSVDWETWL 494 Saccharomyces cerev...
1HS6_A   374 -DPDVAYSSVPYEKGFALLFYLEQLLGgPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKD--KVdv-lnQVDWNAWL 449 human
2XPY_A   456 YKPGMPP-RPHFITALADNVYQLADKWVEMAQhlkttedfRSEFN-AIDIKDFNSNQLVLFLETLTQNGHsnkkpkdfDW 533 baker's yeast
CAG77619 486 FAPGLPN-KPKFDTTLADECYSLASRWKDASD--------ASAFS-AKDIASFNSSQMVVFLITLSEYEGkd----gfSW 551 Yarrowia lipolytica...
CAG85609 469 FGEGLPPnIPQFDPSLADECYRLVDKWVDFAKsns---tdISGFNeSRDIGNFEPDQHKLFLESLTEKFG--------AY 537 Debaryomyces hansen...
O94544   450 HAPGMPPvKPHFDTTLADPCYKLAESWTNSAKns----ddPSKFS-SKDIENWSAGQKSLFLDVVYEAVS---------- 514 Schizosaccharomyces...
P09960   450 YSPGLPPiKPNYDMTLTNACIALSQRWITAKEd------dLNSFN-ATDLKDLSSHQLNEFLAQTLQR-----------A 511 human
AAK93169 521 KSEGMPPvIPNFDESLANVTKELASLWSSKSVa------eLADS--AEIKTTISIHQLIDFLGKLIESKD--------IV 584 fruit fly
Q10740   495 YKPGMPP-RPHFITALADNVYQLADKWVEMAQhlkttedfRSEFN-AIDIKDFNSNQLVLFLETLTQNGHsnkkpkdfDW 572 Saccharomyces cerev...
1HS6_A   450 YSPGLPPiKPNYDMTLTNACIALSQRWITAKEd------dLNSFN-ATDLKDLSSHQLNEFLAQTLQR-----------A 511 human
2XPY_A   534 AKFPVASRALLDIYqdN--IVKSQNAEVVFKMFKFQI----FAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNS--VDRR 605 baker's yeast
CAG77619 552 ANKKELISNMGDIY--S--LANSSNPEVIAKWYSIAI----LAKVESEYPKLADWLATVGRMKFVRPGYRALNS--VDPK 621 Yarrowia lipolytica...
CAG85609 538 SVSEQIIRKLPSIY--Pf-YAASTNGEIKSSWNELLIrfgnYNTTDQIVQDFAMWLGTVGRMKFVRPGYKLLQAy-VSKE 613 Debaryomyces hansen...
O94544   515 -FPHNYIKRMGDVY--S--FAESKNAELSFRFFKLALk----SKYKPLYNTIAERVGSVGRMKFVRPIFRLLNE--ADRA 583 Schizosaccharomyces...
P09960   512 PLPLGHIKRMQEVY--N--FNAINNSEIRFRWLRLCIq----SKWEDAIPLALKMATEQGRMKFTRPLFKDLAAfdKSHD 583 human
AAK93169 585 DLNEGKINLLESTY--N--LKSSKNAEVRFRLNRLIIr----ARLIKRLDEILEFANSNFRMKFCRPIYRDLAGwpEAKP 656 fruit fly
Q10740   573 AKFPVASRALLDIY--QdnIVKSQNAEVVFKMFKFQI----FAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNS--VDRR 644 Saccharomyces cerev...
1HS6_A   512 PLPLGHIKRMQEVY--N--FNAINNSEIRFRWLRLCI----QSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAfdKSHD 583 human
2XPY_A   606 LALATFDKFKDTYHPICKALVKQDL 630 baker's yeast
CAG77619 622 LAKETFEKNKDFYHPICRDMVSKDL 646 Yarrowia lipolytica CLIB122
CAG85609 614 FAISTFTKFESSYHPICKTMVKKDL 638 Debaryomyces hansenii CBS767
O94544   584 FAIETFEKYKHFYHKICASQVEKDL 608 Schizosaccharomyces pombe 972h-
P09960   584 QAVRTYQEHKASMHPVTAMLVGKDL 608 human
AAK93169 657 AAIRNFVNVKDQMMAVCSHTIEKDL 681 fruit fly
Q10740   645 LALATFDKFKDTYHPICKALVKQDL 669 Saccharomyces cerevisiae S288c
1HS6_A   584 QAVRTYQEHKASMHPVTAMLVGKDL 608 human
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