Conserved Protein Domain Family
Renin_r

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pfam07850: Renin_r 
Renin receptor-like protein
The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.
Statistics
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PSSM-Id: 462287
Aligned: 28 rows
Threshold Bit Score: 106.624
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAP20583     109 AYGGHAVVELLNFKAEDssedvtssemwysefenpknpefienhKIQKREVSGIPGVREPTVYeqlrdaarkSYGV---- 184
XP_004930585 246 AYDGSVLVTAVTTD------------------------------IVHTRRAIRSVSGNV---------------ELknsv 280
XP_973593    238 VYKDKVLVSVITSD------------------------------AVHTRRARNILQEKKPEPKdtq----etKVNP---- 279
Q9XTY9       216 AYGGQAVIELLAFEAESgaaekste------------sreipnhNIQKRDTK----------SktptqlareNLQV---- 269 Caenorhabditis ...
1_pfamImport   1 AYGGQAVVELLSFDSESgnvedv---------------revpvhNIKKRDVA--------SDWitalktarkGYQV---- 53 
EGT52551     216 AYGGQAVVELLTFDAETgaeenae-------------sreipthNIQKRDVQ----------YkdvlkaarkSYQV---- 268
XP_003115056 216 SYGGQAVVELLTFDAETgsaeitsen----------reipsdshNIQKRDVS-------IGAFkdalnsarkGFQV---- 274
XP_002643585 217 SYGGQAVVELLTFEAESgaaentae-----------dreipsshNIQKRDAA-------ADAYkdiiqnarkAYMV---- 274
EKC21972       8 LYKDNVVVEVLTVNPGL---------------------------GIYVRKTRSLMAVDDSNV----------NINL---- 46 
ESO08686     254 LFSGNVVVAVVTMNPDL---------------------------GTKLMISRHLQEANATIDTe-------sKFNR---- 295
CAP20583     185 -TEAVSSDYPAMFAMILGLVGALVVTTIYIIVAMVSIDPEKDSIIYRMTT 233
XP_004930585 281 dEDGYSADYAAIFNIILWFGVVFTFTLIAIVYALMDMDPGRDSIIYRMTN 330
XP_973593    280 -AKFYSKDYPVIFNIILWFGVAMTFTLLAICIAIAQMDPGRDSIIYRMTS 328
Q9XTY9       270 -TVPVSSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTT 318 Caenorhabditis elegans
1_pfamImport  54 -TVPVSQDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTT 102
EGT52551     269 -AVPVSSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTT 317
XP_003115056 275 -TVPVSSDYPAIFAIFLGLVVILVIALIYIVVAMASIDPEKDSIIYRMTT 323
XP_002643585 275 -TVPVSTDYPAIFAIFFGLVVILVVALIYIVVGMASIDPEKDSIIYRMTT 323
EKC21972      47 -SKDYDENYPAIFNIILWLMIVMFVVIFGVSYGMWNIDPGRDSIIYRMTT 95 
ESO08686     296 -APKYTYMYPVIFNIVLWFMIAFVITLTWISWSIWHMDPGRDSVIYRMTT 344
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