Conserved Protein Domain Family
Glyco_hydro_79n
?
pfam03662: Glyco_hydro_79n 
Glycosyl hydrolase family 79, N-terminal domain
Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.
Links
?
Statistics
?
PSSM-Id: 461010
Aligned: 31 rows
Threshold Bit Score: 497.906
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EEF50783      30 VVQVTVRGLTSRASTDENFICATLDWWPDTKCDYGQCPWGQAGILNLDLENKILANAIKAFDPLRIRIGGSLQDQLVYQV 109
XP_006345162  24 EIVLTIDASTKVAWTDANYICATIDWWPKEKCNYKQCPWGSASIINLDLTHPYLENAIRAFKGLRLRLGGSLQDQVIYGV 103
XP_006354766  23 DTEFLIDGTVKIAETDDNYVCATLDWWPKEKCNYNECPWGSASLINLDLSHPFLANSIQAFNHLRLRLGGSLQNRIIYDV 102
KRH56864      24 HGSILVDGIQAIAETDDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEV 103
XP_010663310  24 DAIIKVDGATTVAETDANFICATLDWWPHDKCNYNHCPWGYSSVINMDLSHPLFAKAIEAFKHLRIRIGGSLQDQVLYDI 103
Q8L608        26 RTTLVIDGSRRIAETDENFICATLDWWPPEKCNYDQCPWGYASLINLNLASPLLAKAIQAFRTLRIRIGGSLQDQVIYDV 105 thale cress
Q9FF10        29 RASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDV 108 thale cress
XP_006374165  24 RATISIDGTIAVAVIDDNFICATLDWWPHDKCNYNQCPWSYSSVTNLDLSHPLLAKAIQAFRNLRIRIGGSLQDQVLYDV 103
XP_009397277  23 yVTIIVKGSDIVAETDDSFVCATLDWWPPQKCNYNQCPWGQSSVLNLDLTHPFLSNAIQAFEHLRIRIGGSLQDQVVYGV 102
XP_006837042  23 EVLVKVKSVNTIAHTDDNFVCATLDWWPSDKCNYGECPWIEAGILNLDLENPNLGKAIKAFNPLRVRVGGSLQDQVVYHV 102

EEF50783     110 GNYIKKFPHFKRRdgDDYLFGFTRGSLPMDRWDQINALFNQTGVKLTFGLNALIGKQKskdDGSILWVGDWDPQNARDFM 189
XP_006345162 104 GNLKSPCSSFTQQ--KDGLFGFSRGCLPMQRWDELNNLFKKTGALVTFGLNALYGRQP---TNRHAWVGNWDSSNALDFI 178
XP_006354766 103 GNLESPCHPFTKQ--GDELFGFSNGCLHMDRWDELNSFFNKTGALVTFGLNALRGRQR---TSKRVWEGNWDSSNAHDFI 177
KRH56864     104 GSLKSPCHPFQKM--KGGLFGFSKGCLQMKRWDELNHFFDETGALVTFGLNALHGRHQ---ISHTVWGGDWDPSNAKDFI 178
XP_010663310 104 GSLRSPCHPFRKM--NDGLFGFSKGCLRMSRWDELNRLFSQTGVILTFGLNALYGRYQ---IRKGAWAGVWDSSNTQNFI 178
Q8L608       106 GDLKTPCTQFKKT--DDGLFGFSEGCLYMKRWDEVNHFFNATGAIVTFGLNALHGRNK---LNGTAWGGDWDHTNTQDFM 180 thale cress
Q9FF10       109 GNLKTPCRPFQKM--NSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHK---LRGKAWGGAWDHINTQDFL 183 thale cress
XP_006374165 104 ESLKAPCHPFRKM--KGGLFGFSKGCLHMNRWDELNHLFSRTGAIVTFGLNALYGRHQ---IRKGVWGGAWDSSNACDFM 178
XP_009397277 103 PTLGHPCLPFSKM--SGGLFGFSEGCLSMSRWDKLNLLFQRTGAIITFGLNALNGRHP---VHNGMWVGNWNSTNARDFI 177
XP_006837042 103 G-KVKKCPHFKIK--GDGLFGFSKGCLPMDRWNALHHLLSDNGALVTFGLNALYGRQQh--PNKTEWTGPWDSSNARDFI 177

EEF50783     190 KYTISKGYHIDSYELGNELCGSGVSARLDAVEYGNDVIALRKLVNELYPDP-NSRPAVLGPAGFYDQQWFNTFLMTVGPN 268
XP_006345162 179 KYTVAKGYQINSWEFGNELSGSGIGASVDAAQYGKDVIQLHNLLNQVYQNT-PVRPLLLAPGGFYDPGWFGKLLQVSGRG 257
XP_006354766 178 YYTVSKGYQIHSWEFGNELSGKGIGAKVDAEQYGEDVIHLNNLIDQLYKHF-QPRPLLLAPGGFYDKEWFETFLEVSGPG 256
KRH56864     179 NYTISKGYKIDSWEFGNELSGKGIGARVGAAQYGKDLIKLKEILRTLYKNS-TFKPSLVAPGGFYNKEWFDKLLQVTGPG 257
XP_010663310 179 KYTISKGYQIDSWEFGNELSGSGVGASVNAEQYGKDLINLKAIINKLYNNS-NVKPLLVAPGGFYEQDWYAKLLQVSGSS 257
Q8L608       181 NYTVSKGYAIDSWEFGNELSGSGIWASVSVELYGKDLIVLKNVIKNVYKNS-RTKPLVVAPGGFFEEQWYSELLRLSGPG 259 thale cress
Q9FF10       184 NYTVSKGYVIDSWEFGNELSGSGVGASVSAELYGKDLIVLKDVINKVYKNSwLHKPILVAPGGFYEQQWYTKLLEISGPS 263 thale cress
XP_006374165 179 NYTVLKGYKIDSWEYGNELSGSGVSASVSAELYGKDLIKLKDVVNNLYKNS-DLKPSLVAPGGFFDKQWYAKLLQVTGSG 257
XP_009397277 178 KYTISRGYPVDSWEFGNELSGSGVSARVSAEQYAKDLIGLKTLLKELYKNS-RMRPLLVAPGGFFDQKWYTQLLQASGRD 256
XP_006837042 178 NYTISNAQKIDSWEFGNELSGSGIAASVNPTQYGQDLIDLKKVVTELYNSSsMPQPKILAPGGFFDRDWFIKLLESSGSG 257

EEF50783     269 VVDGVTHHIYNLGAGVDKALINKIQDPYFLDQIAQTFKDVSDSVRQFGPWSGPWVGESGGAYNSGGKDVSHTFANGFWYL 348
XP_006345162 258 TVNVLTHHIYNLGPGSDSKLVDKILNPEYLSRTEGTFSSLTQTILRNGPWASAWVGESGGAFNSGGPDVSNAFVDSFWYL 337
XP_006354766 257 TVDALTHHIYNLGPGSDLNLVNKILNPLHLNKIADTFSNLIQTIEINGPWTSAWVGESGGAFNNGGPNVSNTFVNSFWYL 336
KRH56864     258 IVNVLTHHVYNLGPGSDEHLDRKILDPECLSKVESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSVSNTFVNSFWYL 337
XP_010663310 258 TVNVVTHHIYNLGAGVDPNLVSKILNPHYLSRVEETFKSLDKTLQTWGPWASAWVGESGGAYNSGGHLVSNTFVNSFWYL 337
Q8L608       260 VLDVLTHHIYNLGPGNDPKLVNKILDPNYLSGISELFANVNQTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSFWYL 339 thale cress
Q9FF10       264 VVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSFWYL 343 thale cress
XP_006374165 258 IVNFVTHHIYNLGAGMDPNLVNKILDPHYLSKVSETFSNLSQTIQQNGPWASAWVGESGGAYNSGGRHVSDTFVNSFWYL 337
XP_009397277 257 VVNALTHHIYNLGPGDDYRIESKILDPQYLSRITDTFRNLQLTIERHGPWSSAWVGEAGGAYNSGSRRVSNKFLDSFWYL 336
XP_006837042 258 VVDVLTHHIYNLGAGNDPIVPNRMVDPFYLSEIAETYKSIQLTIQDFGPWSAAWVGEAGGAYNSGGPNVSNAFIDSFWYL 337

EEF50783     349 DQLG 352
XP_006345162 338 DQLG 341
XP_006354766 337 DQLG 340
KRH56864     338 DQLG 341
XP_010663310 338 DQLG 341
Q8L608       340 DQLG 343 thale cress
Q9FF10       344 DQLG 347 thale cress
XP_006374165 338 DQLG 341
XP_009397277 337 DQLG 340
XP_006837042 338 DQLG 341
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap