7CTP


Conserved Protein Domain Family
Niban-like

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cd23949: Niban-like 
Niban-like protein
Niban-like proteins contain an N-terminal Pleckstrin-Homology (PH) domain that may be involved in binding to specific ligands. Phosphatidylinositol (3)-phosphate (PI3P) was recognized as the innate ligand of the PH domain of MINERVA (melanoma invasion by ERK, also known as FAM129B) PH. Niban family proteins have been found to regulate phosphorylation of a number of proteins involved in the regularion of translation, such as EIF2A, EIF4EBP1 and RPS6KB1. They may also be involved in the endoplasmic reticulum stress response (FAM129A, Niban-like protein 1), suggested to play a role in apoptosis suppression in cancer cells, while Niban-like protein 2 (FAM129C) is a B-cell membrane protein that is overexpressed in chronic lymphocytic leukemia.
Statistics
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PSSM-Id: 469558
Aligned: 30 rows
Threshold Bit Score: 445.203
Created: 28-Apr-2023
Updated: 28-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligand
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:There are both positively charged and negatively charged residues in the proposed ligand binding pocket.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       # 
7CTP_A          8 LDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIegtg------lpqaQLLWRKvpld----eriVFSGNLFQH 77   human
XP_001745588    2 IDDAVRKEVQEETQRQMTDFGKDFMSAYKGQLVGEAIEKHeagee----egpalELQERPesepl-vdtepLKTATFIKR 76   Monosiga brev...
CUG90601        4 DLSAELGESREITTNFIKIFAIQYSKNYLIALMRIAKKDLlkeaa-----gprwKLLKCDkcppp-qiqktGTVNKLSKY 77   Bodo saltans
CUE90095        4 NLSAELDEARDITTQFLKIFAIEYTKMYLVALMKSAKKTLakeaa-----gpqwSLLKCLkapaa-pvlkaGTVKKLSKY 77   Bodo saltans
XP_805277       4 AFSGEMSDTRELASVFLDAFGREYEKLYMRFMIQRVRKAMqheaekknedtvmwKLYRAPyiptqinereqVMAAKLSKH 83   Trypanosoma c...
XP_029237255    4 SFSAELSDTRELASVFLDTFGREYEKLYMWFMVQRVRKAMqhesetsngntvawRLYRAPeiptqvndrdqFMAAKLSKH 83   Trypanosoma r...
KAH7824419     18 TINKELTRVLQPIGRRMNETVQYYVLWRNILILRRKREEAplm--------vagKLSVPIr----------PFCGWVDKE 79   Monocercomono...
XP_009860630   15 IEGHSADQVYQSNLDYAKIFVKRYEAAYMWFYLQKVNREYsgkdg-----cqkwQLRQRNwqsy----nrpIKQGSLYVL 85   Ciona intesti...
KAH7823532     18 TINKELKRILQPLGRKMSESVQYYVLWRNVLLRKRKKEEAplm--------vsgKLSVPIr----------SFCGWVDKE 79   Monocercomono...
NP_001371058    9 LGRRQRQQLQGQVNGMLRTFLPCYRRQLAAAVLRHISQELgpqd------pagcQLSHTKklp-----rvrEHQGPLTLL 77   Mus musculus
Feature 1         #       # #                         #                                           
7CTP_A         78 Qed-sKKWRNRFSLVPHNYGLVLYENKAAYERQvpPRAVINSAGYKILTsv----dQYLELIGNSLPGTTAKsgsa---- 148  human
XP_001745588   77 Gdv-rKNWKERFFVVRKDHNIDYYESEQAFKDGkkPKGTINLSGYEVVTdpngrkiKQKQDQAKEFGEEIGDve------ 149  Monosiga brev...
CUG90601       78 L----KKWNPRFMIVKGDYLIDYFETEEKYNSKakPLGTINMSNKNLHR-------DANDTILNRLIALAEKckinvd-- 144  Bodo saltans
CUE90095       78 L----KKWNVRYAVCKGDHLIDYYETEEKYNAGakPLGTINMSNKNLHR-------DANDTVLNRIIALAEKcgvnvd-- 144  Bodo saltans
XP_805277      84 L----KRWKPRFLSLRGDFILDYYASREDYAGKkqPLGSINLGNVVVNC-------DATRATEERLDRLAAIcsvart-- 150  Trypanosoma c...
XP_029237255   84 W----KHWKPRFFVLRGDFLLDYYESRNDYLEGrhSLGTINLGSVVVSC-------NATQATEERLDRLAAAfsvars-- 150  Trypanosoma r...
KAH7824419     80 Gga-iKTWKRRWMVLTTDREMYYYTDLAAKDRGe-SKGSFSLEGYEIVEdp----iAAQTQRNRKIADMIGWtdrts--- 150  Monocercomono...
XP_009860630   86 SkntgKKWKQLYCVLHSNYTLEFYKSKEDYEQSngQLFNAKYSGYKVLTdvdtylhKKLEISCCEFGYVNQDlvafsrkv 165  Ciona intesti...
KAH7823532     80 Gga-iKTWKRRWMVLTPEREMFYYTDLSAKDRGe-SKGSFSLEGYEIVEdp----iAAQTQRNKKIAEMIEWkdkts--- 150  Monocercomono...
NP_001371058   78 Qgh-pPQWQPTFCVLRGDGRLEWFSHKENYESGgcPLGFAALTGYTLLTsq----rEYLCLLDDLCPSSSGDlaleep-- 150  Mus musculus
Feature 1                               #                                                         
7CTP_A        149 ----pilkCPTQFPLILWHPYARHYYFCMmteaEQDKWQAVLQDCIRHCNNGIPEds---kvEGPAFTDAIRMYRQSKe- 220  human
XP_001745588  150 ------ydKYEPLTMECFHDSKRRWLFKFetqdQFDEWAITFAECSKLVSSRTMEdd----qMYEAFQEAYTARKSHTw- 218  Monosiga brev...
CUG90601      145 --dmpkpdKYPDFTLEIFHERKGPIYIQC----PDEESWKSWCDIIERCRWHAPRyn---lyEDKAHVFAFPNALWRTrw 215  Bodo saltans
CUE90095      145 --empkpeRYPDFTLEIYHEQKGPIYIEC----PGEEEWKQWCDLFERCRWQAPRln---lyEDKAHLFAFPKALWRTrw 215  Bodo saltans
XP_805277     151 --evsapeKYPEMTVELYHPRRCPVYLQF----PKKDRYDLWCGIFKRAHWLMDRvttndrvHQRAFVEALRRARVMCg- 223  Trypanosoma c...
XP_029237255  151 --evpppeTYPELTVELYHPRRATIYLQF----PVRDRYDVWCGFFQQIHWLTERvttkdrhHQRAFIEALRRARVMCg- 223  Trypanosoma r...
KAH7824419    151 ---ipqptRYPPNTIELYHHKDRLWHFAPlssaEKNEWVKCLRNALIQVTSYKSDfay-stcFYRAMAHSLEAADCRNk- 225  Monocercomono...
XP_009860630  166 tmigragkRPTQHIFSASHTWRATTYFAAetaiEKESWVRVLRDAIRHLEGVHNKde----vGNDAFMFAIEQSIRLQe- 240  Ciona intesti...
KAH7823532    151 ---ipqptRYPANTIELYHHKDRLWHFAPlsvtEKIEWVKCLRNALIRVTSYKSDfac-gmsFYRAMAHALEAASSRAk- 225  Monocercomono...
NP_001371058  151 ---lrvleEPVSFALFLVHPFRAHLCFCArsrkAHRAWRLGLQGAIRLRATVLQRsr---apAACAFLDAVLLYRRRRg- 223  Mus musculus
Feature 1                                                                                         
7CTP_A        221 lYGTWEMLCGne--vQILSNLVMEELGPELKAELGPRLKgkp-qeRQRQWIQISDAVYHMVYEqAKARFEEVLSKVQQVQ 297  human
XP_001745588  219 -YYYWKNYSGte--aDMLTDLLTDNARRRFLESTIRNLTgpi-kmKKVALGKIVAFLRTIISGiVKAQFTALITALNAVK 294  Monosiga brev...
CUG90601      216 eCDMWGWWWGgggeeAQLVDAINDKIADVVLYKLDCKLTmpw-aaRSRIRNKFIQTVDGIVSSaVGPAWKAAYDAVTKIR 294  Bodo saltans
CUE90095      216 eVGMWGWWSGgggeqSQLVDAINNKIADVVLYNLDRKLTqsw-tvRQKIRNKFISTVDGIVSTaVGPAWKAAYSAVEAAR 294  Bodo saltans
XP_805277     224 -LPDSLEFSGge--tTILQDAITELVDAQIVPKLLLGMSgrswrdRMSQLRSFIAKSDELLKNfVWGKWHATQGKTCGRR 300  Trypanosoma c...
XP_029237255  224 -LPDSLEFSGle--aVILQDAINELVDTQVVPKLLLTMSgsswknRMSQLNLFIEASDELLRKfVWGKWHAMQGKTCVHR 300  Trypanosoma r...
KAH7824419    226 -IPIWQDDFR-----LTIFQFATEQIEPDLFYDKYKRLTgsf-leQAAQYQAIRVEFHSYLREqIRTATNDLLLQIKEKK 298  Monocercomono...
XP_009860630  241 fAVDRSLLSGtq--eEILADMMIEIQSQDCKVVLLPHITggl-vtKYKTWNFIMFETYKWMKKiIGLEYTQQRLEAEIRC 317  Ciona intesti...
KAH7823532    226 -MPIWLDDMQ-----LSIFQFATEQIEPDLFYDKYKRLSgsf-peQAAQYQAIRVAFHTYLREeIRTSTADLLARIKDKK 298  Monocercomono...
NP_001371058  224 yAGGDDGILGsd--aEVLSAELMRELLPGLRAQTLRSLRgag-raRARACAEFLDAVHTAVLAwASSGLRAFQPEKDALL 300  Mus musculus
Feature 1                                                                                         
7CTP_A        298 PAMQAVIrtdMDQIITSKEHLASKIRafILPKAEVCVRnHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVin 377  human
XP_001745588  295 ETVKKGLetaIGPIVELRGKLCGQLDgsATPIINPVAEkVLSPMATALAGFLSPTLYSAYVGPKPEFEKECKRYSEKVad 374  Monosiga brev...
CUG90601      295 PEVEPKIkegMQPIVDAQKSIQDEISkqVEAGSKDFIAeKVLPHLAPLLDIIFSPVLDGFRILLKAFDVAIEKGKEKYet 374  Bodo saltans
CUE90095      295 PEAEPKIkegMQPIVDAQKKIQDEICkmVEAGSKDFITeKVLPHLSPLLDIVFSPVVDGFKLVIRAFDVALERGREKYev 374  Bodo saltans
XP_805277     301 AMLEAKVrdnMNKLNAFEEPLREEVHnyMSGETKSFLAtRVEAPLKKLAANVAPKLCAVYAALPRIYEACVSQGKVRYep 380  Trypanosoma c...
XP_029237255  301 VMVEARVrdnMEKLNAFEEPLREEVHnyMSGETKLFLEaQVEEPLRKLATKVVSPLCAVYATLPRIYEACVSQGKVHYep 380  Trypanosoma r...
KAH7824419    299 RDTEARIisrISEISALHKTVKEEVGkaNIDLIKRFIAsHLAPNIETTFNLIEQPIKQCFVEADRLLKSHCEDLMNELer 378  Monocercomono...
XP_009860630  318 KEQRVNMiakMPEIFDTYENCAKAIEgeLVECFDSVLKsEILPHVPRVISTLYDSLMGPIRGARELFVTLVEGVVRKIst 397  Ciona intesti...
KAH7823532    299 REAESQIianFAEIAALHKAVKDQVGqaNIDLIKRFVTsHLLPNVEMVFGLIEPPVRMCFVEADRLLKKHCELLEEELek 378  Monocercomono...
NP_001371058  301 AALERMVradLEQILQQRALGARRIEaeIQGAVEACLCqKVDPQLPQLTLALLSPVEATLRAVRTLLIQGMDRLCHYLrk 380  Mus musculus
Feature 1                                                                                         
7CTP_A        378 e----ggIDKLGEYMEKLsrla-------yhplKMQSCYEKMESLRLDglq----------qrFDVSSTSVFKQRAQIHM 436  human
XP_001745588  375 gspqdsaDQSLRWSTECSywmyh------dgfdYLYKIVDKYSDLKGMlpdvvrsnetmsnliDSYLDLYSWTWNVRSSI 448  Monosiga brev...
CUG90601      375 ------kEDRLYMVWHYNynsey-----wdaerKMWDLYEPLWAIRIV---------------FDDIYPWTITGRARRRL 428  Bodo saltans
CUE90095      375 ------rEDRHYMVSHHGynsef-----wdaerKIWDLYEPLWALRLV---------------FEDIYPWSITGKARRRL 428  Bodo saltans
XP_805277     381 s----sdHMFLASQYNCIgecy-------eaerVLWQLQKPIASMKDEf-------------nDRVFEWRVIQESVVMPA 436  Trypanosoma c...
XP_029237255  381 r----gdRMFLASQYNCIgecy-------eaerRLWQLHEPIASMKGVf-------------nGLVYEWRVIQDAAVMPL 436  Trypanosoma r...
KAH7824419    379 k----trDRRLREAAELIepliqtavdsaslspLLQACTEVGLRIESMrk-----------smTSHLNAKEITHTLSHLM 443  Monocercomono...
XP_009860630  398 ss--pdfVNNIDQYFLSTldya-------prnpEFMHPTSNTNMIALSqiq----------avFPESNLTPFLLSIYTHQ 458  Ciona intesti...
KAH7823532    379 k----krDRRLRDPADLIepliqtaidssslspLLQACAEVGLRIETLrk-----------gmISHLSTKEITFTLRHVM 443  Monocercomono...
NP_001371058  381 n----psGTRLCREVYEFgeip-------wdpeLMQACYREAERNHSHlvql--------akpFDFLGMRSLVFGAQDLA 441  Mus musculus
Feature 1                                                                                         
7CTP_A        437 REQMDNAVYTFETLLHQELGkgptk---eelcKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKkl---aPT 510  human
XP_001745588  449 RALYDRAAYTYTQAINEDPAta---------nEKHDAVFAATWASFEHDAKFSVVQNLADFVTGPLSFVLKDsi---lEK 516  Monosiga brev...
CUG90601      429 RKTLDNALYTFEHILEDGKDq----------gKTWDEAAREARELMVQDCRTSVARVLSMILFGVVENFFEKlv--irPA 496  Bodo saltans
CUE90095      429 RKTFDNALFTFETILEDGKEs----------gKTWEQAADETRARLARDCRTGILRVLGIILFGVVENFFEKlv--irPA 496  Bodo saltans
XP_805277     437 RRIIANGVFTFETLFERDKIr-----------RPWDDVLREVRGFLEADSRTMAQEALTLLLYETVVHFFRD------EH 499  Trypanosoma c...
XP_029237255  437 RRIIANGIFTFETLFERDKIr-----------RPWDAVLREVGGFLEDDAHTMARDSLIALLYETAVNFFRD------EH 499  Trypanosoma r...
KAH7824419    444 TIFVVRGFTTLEVELSLSLSsdptrgepdrlpKIVGKILDSVFDRFKFDARVMTQRITLNLMHAILDLPFFRaamavlDA 523  Monocercomono...
XP_009860630  459 QKLLDSAICTFEALCGDAVTvgng----kltkSLVTKIQARVLKKLDFDILLAQKRLFRSVIQSATMEHTRAai---eHA 531  Ciona intesti...
KAH7823532    444 TIFVVRGFTTLQVELGMALEedptrgdadrlpRTLGRVLDSVYDRFKFDARVLTQKLILNLMHGILDLPFMRaamavlDT 523  Monocercomono...
NP_001371058  442 QQLMAAAVTTFLQLADQCLTsaldr---sqaaEQLGKVRGLVLKKFTSDSETTRWRFTRDCLLRIFWPFVWSql---rLR 515  Mus musculus
Feature 1                                                                
7CTP_A        511 CKSELPRFQELIFedf---------arFILVENTYEEVVLQTVMKDILQAVKEAA 556  human
XP_001745588  517 LTPLLEPIDSLIP--------------ETLQEMISGTLILETVLDNHVGSIASGA 557  Monosiga brevicollis MX1
CUG90601      497 RKLVAPLAEKIPQai----------kdFVDPEALLEELLYTILRNTCTNVFNPYT 541  Bodo saltans
CUE90095      497 RKLVKPLSDSIPAai----------kdFVDPDDMLEELLYTILRRTCGMVFEPYT 541  Bodo saltans
XP_805277     500 VQPSLKKLKSTMIaplenrvtqelrpfILSVQEIVADVLEGDLRDMCFSIAKGAI 554  Trypanosoma cruzi
XP_029237255  500 VKPSLKRLKATMIaplesrvpddlrpfILGVQEVVADVLEGDLRDMCRDIAEYAI 554  Trypanosoma rangeli
KAH7824419    524 AKGQIREMVPTSMi------------eIFNADCIMNDILYTFSHTTIVHTIGAKM 566  Monocercomonoides exilis
XP_009860630  532 CKGKMSGFEYLIDpsl---------stFMPINNVFTSVLTKHFNDLFEPVLKSSL 577  Ciona intestinalis
KAH7823532    524 AKGQIREMVPNSMm------------eIFNADLVMSEILYSNSHSTIIHAVGGKM 566  Monocercomonoides exilis
NP_001371058  516 CNLEPPEVDGDILamg---------wqVLTTEGVYRDVIQGLLLQRIDRELKKIL 561  Mus musculus

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