Conserved Protein Domain Family
PCC

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TIGR00864: PCC 
polycystin cation channel protein
The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Statistics
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PSSM-Id: 188093
Aligned: 2 rows
Threshold Bit Score: 4865.46
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAB86683  120 DLSNNQISTIEEGTCNRQCNLTQIDLSSNPFECHCKLFRLVSWLREKGVKVRRPEATLCDNPPALRHRPLLNVSLLT--C 197  torafugu
P98161     97 DISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDsgC 176  human
AAB86683  198 DLNYVACLKESSSGGGAERSelviFSSSTPGNFTREQCNSVCFTASHRYGGLGGRHECLCSTN--SEPNFISESQCS--- 272  torafugu
P98161    177 GEEYVACLPDNSSGTVAAVS----FSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAqpSSASFACLSLCSgpp 252  human
AAB86683  273 ----AACTNPQVMEVIG-ALP-LPIQNVHSSIS------FSAASSVAPVTMSWDFGDLSSRVNTSGAggttTTSHKYGHP 340  torafugu
P98161    253 pppaPTCRGPTLLQHVFpASPgATLVGPHGPLAsgqlaaFHIAAPLPVTATRWDFGDGSAEVDAAGP----AASHRYVLP 328  human
AAB86683  341 GRYLVSLMGWSGNNKVSAHGEVVVTLPP-KLELHCPTLVVANQSLQLTLVSWGSVDVDVDWKITKHGVQVAKAS-PHCPK 418  torafugu
P98161    329 GRYHVTAVLALGAGSALLGTDVQVEAAPaALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVhPLCPS 408  human
AAB86683  419 DGVLHEESSRCFQIVPGELSWTDARKQCLDRG-GDLAIVRNDALRNLLARKVTHSMErgVWLGLSDVNSAGK--LHWVNG 495  torafugu
P98161    409 DTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAgAALAMVDSPAVQRFLVSRVTRSLD--VWIGFSTVQGVEVgpAPQGEA 486  human
AAB86683  496 SEAQEGEEGLAPWSSVARGNLCVSLDQRSQTSSHSCNARRAYVCQYNPQVRVPDSGVFAMGLAVFPSHHLLQATAAMITT 575  torafugu
P98161    487 FSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGL 566  human
AAB86683  576 PPPpHGGVEVLLFPALSFVRAGRLSSLEFVTRELSSQTHILFQIYRPrcrYPGCGGPACSPMALCVPSESRSADPPSCPK 655  torafugu
P98161    567 SAP-HEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRL---LSTAGTPENGSEPESRSPDNRTQLAPACMP 642  human
AAB86683  656 LEQWCPFQHRCLPLSSPCQPSSCLN-CSQGHQLPSEArmplYTLQYEVLFSLTAGPAAHVLLQDQLEDLLVSRGDVIALQ 734  torafugu
P98161    643 GGRWCPGANICLPLDASCHPQACANgCTSGPGLPGAP----YALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQ 718  human
AAB86683  735 HDAGPASLIHCQSSP-HSLWRQPVFALNLSEWFGInntpvppdnlagdgadplpdpeldLKALVEGTRGswleNAVCPIR 813  torafugu
P98161    719 HDAGPGALLHCSPAPgHPGPRAPYLSANASSWLPH------------------------LPAQLEGTWA----CPACALR 770  human
AAB86683  814 VLYVGQSETRLRGAELSAGLPQPGLYNLLVTSAKQSDLVSASCSLQVLPPLD-LTVLHPSPQNGTLFLESNRTRLLLRVQ 892  torafugu
P98161    771 LLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAgLRVIYPAPRDGRLYVPTNGSALVLQVD 850  human
AAB86683  893 S--RYETKAFYRTSNSSATFHPYCPQEFSsrlchpsTSEGSGAEVAEPSMYAVLDLN-LKIKEHTgpvqVELMAHNNVTE 969  torafugu
P98161    851 SgaNATATARWPGGSVSARFENVCPALVA-------TFVPGCPWETNDTLFSVVALPwLSEGEHV----VDVVVENSASR 919  human
AAB86683  970 ASLTVLVQLEESLRGLVVQPHPARRVLMESVVSYTASVLEGSNPTFKWTVDDKPFFTYYNTVLNVIYQHADVYKLTVTAM 1049 torafugu
P98161    920 ANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTAS 999  human
AAB86683 1050 NHVSTLTEDFNVTVDRLQPMTNLTVKGVPDVVPQGSTQTLTTSVLIDMAVPATVRWSFGDGGYEQFEHKPPYPSSLTCPE 1129 torafugu
P98161   1000 NHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPD 1079 human
AAB86683 1130 -SPYQVLLSSNVTYIYSQPGIYTAVVSVSNRYENISRSINMSVYSILTRVDIQTEPSLLLAGKTADFEAHPLPSPYGIHY 1208 torafugu
P98161   1080 pSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLY 1159 human
AAB86683 1209 EWNFGDGSALLQGRR--VAHTFEKSGPFNVCVSVNNTISSTAVCTEMFAYEEIESLTAESSSPTELHSATTVRAHLSSGN 1286 torafugu
P98161   1160 TWDFGDGSPVLTQSQpaANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGD 1239 human
AAB86683 1287 NITWTFSMGDGKSYTLSEPTVSHKYAKDGRFTVNITAMNAVSSGWTIIPVEVFVFQVAGIEPSGCVGEHALVNFRARVSG 1366 torafugu
P98161   1240 NITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTG 1319 human
AAB86683 1367 NASSYLYEWSFGDGSPNETHHGNPGISHTYRGNGTHPLSLTITSGVSKANFVTQVCVQPVLTKISVTAEKSHFAVGEKIQ 1446 torafugu
P98161   1320 NPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAW 1399 human
AAB86683 1447 FQARAEPEFNYTYEWDFGGEEDLVLPHAPANVVKTYNNPGCYVVTVAASNNVSNTTGSISIEVLTPVGAVVFQHNGTHYn 1526 torafugu
P98161   1400 LVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLG- 1478 human
AAB86683 1527 nLTLGVPYYFSAFSSASNVSYLWNFGHGNLLKGQNILHTFNTPGHHNITLTAANRVGKNHTTVPVAVLASVSGLTINSSL 1606 torafugu
P98161   1479 -LELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASR 1557 human
AAB86683 1607 VNVPLNTSVHFEAHMDEGDSVRFSWILCDHCTPIFRNNTMFYTFRSVGTFNIIVTAENDVGAAQASIYLFVQRELEGLQI 1686 torafugu
P98161   1558 TVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQV 1637 human
AAB86683 1687 LVEtaegggggvqeldWCYFETNRVVRFHAGFKEGTNLTFTWNVILKnepDNSIFNLTGKTAKVNPSKPGPCDIFLQAAN 1766 torafugu
P98161   1638 VGG-------------GRYFPTNHTVQLQAVVRDGTNVSYSWTAWRD---RGPALAGSGKGFSLTVLEAGTYHVQLRATN 1701 human
AAB86683 1767 LLGQVTVNRTIYFLEPARNVQLQISDNPVAVNALINMTVLNMEGSNLQYRWFVNG-DDLQWSKSWMSHTFTSAGQKQVTV 1845 torafugu
P98161   1702 MLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEgLSWETSEPFTTHSFPTPGLHLVTM 1781 human
AAB86683 1846 KVFNEVSSEVRSEIVSVQEVISGLKITSADATEQnYFPTDVSVCLQGELSTGTNVTWSWLIDGMS-KMQKKACVTFPKPK 1924 torafugu
P98161   1782 TAGNPLGSANATVEVDVQVPVSGLSIRASEPGGS-FVAAGSSVPFWGQLATGTNVSWCWAVPGGSsKRGPHVTMVFPDAG 1860 human
AAB86683 1925 TVAVTLNATNDVSGKVVSREFFVQERIFSLELKASKKIAAINEKVEFSISLVAGTNVNLSLSISRDATVVLqPNQTYVHT 2004 torafugu
P98161   1861 TFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVL-PGPRFSHS 1939 human
AAB86683 2005 FSRVDTYMVNLTAYNEVSCKRRNLHIEVMEPVRGLSIQDSCAA-IAVGEKKVFVANVQTGKPVHFLWTFDLHHLHKET-- 2081 torafugu
P98161   1940 FPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPgIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSlv 2019 human
AAB86683 2082 -HMGKEVSYTAEEEGLLTIYLGAINALHAQNITRQMLAQNVLMDAVLYALPqdTFVNKMVTMNVLVTPKSNFMDCLWIFG 2160 torafugu
P98161   2020 iLSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFG 2097 human
AAB86683 2161 DVSAPRHTNNTTVGHEYTHPGHYRVQVNCSNLVSWVSAHAEINVSVLECEEPEVQVVQAPRLAIWRSQPTLVEASVDLKG 2240 torafugu
P98161   2098 DGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRD 2177 human
AAB86683 2241 CLRYGAQYLWQILSAPSCDNDPHFASGRVNGatrsfpviplpaeVDVQRLQLSLPKMVLAAGNYTLVFSLSYENVPLKKA 2320 torafugu
P98161   2178 CVTYQTEYRWEVYRTASCQRPGRPARVALPG-------------VDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQS 2244 human
AAB86683 2321 ACLQLGVMAARLMPIIEGGTYRVWSRTQDLQLSAEQSYDPNMDPDNQSLLHYHWECQSTSKGPEHCSTLSFGLGSkGPVL 2400 torafugu
P98161   2245 IQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRG-SSTV 2323 human
AAB86683 2401 GISGSELEAGIEYTFKLSIGKEGMPPESTTQTVLVQSGHIPMVYLECVSCKAQSLYEVSQNSYVYLRGTCSNCQ-GFHRG 2479 torafugu
P98161   2324 TIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSsGSKRG 2403 human
AAB86683 2480 RWSAVTLQNDTLVLDSSSTTTGSGGMNLVLRQGVLHLGESYNFTLHVTDDSLDGEGAASITLHHNMPPDGGECHLRRGGe 2559 torafugu
P98161   2404 RWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG- 2482 human
AAB86683 2560 tgqehgdkedevwRIETLLDRVQFSCSGYSDLGVSETPLLYSLLVNRCRDDYCEEFYVYRGSSPEHSAFLPPGFSsAQHR 2639 torafugu
P98161   2483 -------------AVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFR-PHFE 2548 human
AAB86683 2640 VSVFITVEDHQGAAIRALNKTIKVVLPDPPPEYSSLPHWLSDLIDSKLKKLLDQGDFQRVRELSLVLITVLNEYEQTRES 2719 torafugu
P98161   2549 VGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDV 2628 human
AAB86683 2720 VRVSRVERGYRGRVRNNITRALTALDLTTVNDIQQTSAALAQCTAVSREFICEECQNSTLNKLESMLEILQTDTKQGIVT 2799 torafugu
P98161   2629 AAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVT 2708 human
AAB86683 2800 PTEIADNILNIMGDLIHQVS 2819 torafugu
P98161   2709 PTAIGDSILNITGDLIHLAS 2728 human
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