Conserved Protein Domain Family
Cox20
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pfam12597: Cox20 
Cytochrome c oxidase assembly protein COX20
Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 and its homologs (also known as FAM36A in metazoa. Human CIV is formed by three catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly synthesized COX2. It may act as a chaperone in the early steps of COX2 maturation.
Links
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Statistics
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PSSM-Id: 403707
Aligned: 53 rows
Threshold Bit Score: 109.945
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAY69562      46 TSPLKQAVNKISIKDFSpaNLISIPCFREAGLSGFTVMAVFGSITFLYHKNIQKTANWAFGGFLLGSIFGWEQCNSIRRK 125
XP_002614173  46 QPTIVDAFERIKLSDFTfeNYVSMPCFREAMLTGFQAMGVLGVVTFLIHKNPGKSANWGVCGFFLGSVVGWEQCRSIRRR 125
Q6BKI4        46 PPAYSDALKEFKLSDFSmsHFVSMPCFREAMITGFQAMGVLGTVTFLIHKNPNKSINWAVCGFFLGNVVGWEQCHSIRRK 125 Debaryomyces ha...
XP_006690438  46 QSMYEGALSQVRLADVKpsTYIGMPCFREAMMTGFQAMAVLGGVTFLIHKNPNKSLNWGVCGFFLGNIVGWEQCRSIRRK 125
EDK36259      49 ESMYREAFKQVKLSDFTisHYVNMPCFREAMITGFQSMGVLGAITFLIHKNPQRSVNWAVCGFFLGNIVGWEQCRSLRRK 128
XP_001385010  46 EPTLIDAAKQIKLSDFSveRFIGMPCFREAMITGFQAMGVLGTVTFLIHKNVSRSLNWSVCGFFLGNVVGWEQCRSIRRR 125
XP_007377873  50 QPTILDAAKQISLSDFTidRFVHMPCFREAMITGFQAMGVLGVVTFLIHKNPQKSFNWSIGGFFLGNLVGWEQCRSLRRR 129
CCE41105      61 QPTLVDAAKSIHLSDFTidRFITMPCFREAMITGFQAMGVLGVITFLIRKDLNKSLNWSVGGFFLGNMVGWEQCRSLRRR 140
Q5AH72        51 QATLMDAAQRIKLSDFTvdRFISMPCFREAMITGFQAMGVLGVVTFLIHKNVQKTMNWSVGGFFLGNIIGWEQCRSLRRK 130 Candida albicans
XP_001523360  75 QATLSDAAKMIKLSDFTfdRFVQMPCFREAMITGFQAMGVLGVITFLVHRNFKKSMNWSVGGFFLGNLVGWEQCRSLRRR 154

CAY69562     126 SMMTAQIAKESLEQRKQQELRNK 148
XP_002614173 126 SFQTVEAAKQANQEKMRKKHEHS 148
Q6BKI4       126 SFQAMEKAKEANQKKNEKKWEEK 148 Debaryomyces hansenii
XP_006690438 126 SFETVEKARQVKQQKNEQKWEDK 148
EDK36259     129 SFETVEKARQKNQEKQAKKWEEK 151
XP_001385010 126 SFQMMEKAKQAKEERNAKSWEKH 148
XP_007377873 130 SFEVMAKAKQAREEKNMKKWEEL 152
CCE41105     141 SMHMMEKAKQEREEKNRKKWQEL 163
Q5AH72       131 SFQMIEKAQQERDEKNKKKWAEM 153 Candida albicans
XP_001523360 155 SFEMVEKAKREKEERHRKKLEEL 177
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