1IS8,1A8R,1FB1,1GTP


Conserved Protein Domain Family
GTP_cyclohydro1

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cd00642: GTP_cyclohydro1 
Click on image for an interactive view with Cn3D
GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In vertebrates and insects it is the biosynthtic precursor of tetrahydrobiopterin (BH4) which is involved in the formation of catacholamines, nitric oxide, and the stimulation of T lymphocytes. The biosynthetic reaction of BH4 is controlled by a regulatory protein GFRP which mediates feedback inhibition of GTP-CH-I by BH4. This inhibition is reversed by phenylalanine. The decameric GTP-CH-I forms a complex with two pentameric GFRP in the presence of phenylalanine or a combination of GTP and BH4, respectively.
Statistics
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PSSM-Id: 238349
Aligned: 12 rows
Threshold Bit Score: 271.947
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:a complete active site of the GTP-CH-I decamer is formed by two monomers from one pentamer and one monomer from the other pentamer contribute to the GTP and Zn2+ binding site
  • Citation:PMID 8674705
  • Citation:PMID 9165069
  • Structure:1GTP_A,B,J; GTP-CH-I decamer binds SO4 (in place of GTP)
  • Citation:PMID 7663943
  • Structure:1A8R_A, B; GTP-CH-I pentamer binds GTP
  • Structure:1IS8_A,B,J; GTP-CH-I binds Zn2+ at the active site in humans and bacteria
  • Citation:PMID 8618856

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #  #                                          # #
1IS8_A     46 LNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQ-FFTKGYQetisdVLNDAIFDe-DHDEMVIVKDIDMFSMCEH 123 Norway rat
1A8R_A     34 TRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVdEIFSGLDya-nfPKITLIENkmKVDEMVTVRDITLTSTCES 112 Escherichia coli
1FB1_A     12 LNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQ-FFTKGYQetisdVLNDAIFDe-DHDEMVIVKDIDMFSMCEH 89  human
1GTP_A     34 TRKSLIAGHMTEIMQLLNLDLADDSLMETPHRIAKMYVdEIFSGLDya-nfPKITLIENkmKVDEMVTVRDITLTSTCEH 112 Escherichia coli
127481      4 VNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYA-EVFSGLNed-pkEHFQTIFGe-NHEELVLVKDIAFHSMCEH 80  Bacillus subtilis
1169876    33 ERRESIAKHMHEVMKLIGLDLRDDSLEETPNRLAKMFIdEIFSGMDya-nfPKMTKIKNqmKVSEMVQVNDITLTSTCEH 111 Haemophilus influe...
2494695    25 VSQAEMEAAVRTLLLGVGEDPEREGLLKTPKRVAEAYR-FLTSGYSqslddLVNGAIFDe-GHNEMVLVRDITAFSLCEH 102 Synechococcus sp. ...
2494697    38 DHLKSMCNAYQSIIQHVGEDINRQGLLKTPERAAKAMM-AFTKGYDdqldeLLNEAVFDe-DHDEMVIVKDIEMFSLCEH 115 Caenorhabditis ele...
O13774     50 EKVKKISNAISTILECLGEDPERQGLLGTPERYAKAML-YFTKGYEqnlteVINEAVFQe-DHEEMVIVRDIDVFSLCEH 127 Schizosaccharomyce...
9297102    88 ALLPDMARSYRLLLGGLGENPDRQGLIKTPERAAKAML-YFTKGYDqsledVLNGAVFDe-DHDEMVVVKDIEMFSMCEH 165 fruit fly
CAC28574  127 ERLDKMKGAVRTLLECIGEDPDREGLLATPERYAKAML-FLTKGYQenvrdIVNGAIFQe-GHNEMVIVKDIEVFSMCEH 204 Neurospora crassa
18266889    1 MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQ-EIFSGLGqt-aeEHLSKSFEi-IDDNMVVEKDIFFHTMCEH 77  Streptococcus pneu...
Feature 1     #                   # ##   #          ###                          # #   #      
1IS8_A    124 HLVPFVGRVHIGYLPN-KQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMN 202 Norway rat
1A8R_A    113 HFVTIDGKATVAYIPK-DSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDAT 191 Escherichia coli
1FB1_A     90 HLVPFVGKVHIGYLPN-KQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMN 168 human
1GTP_A    113 HFVTIDGKATVAYIPK-DSVIGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTNNVAVSIDAVHYCVKARGIRDAT 191 Escherichia coli
127481     81 HLVPFYGKAHVAYIPRgGKVTGLSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG 160 Bacillus subtilis
1169876   112 HFVTIDGKVCVAYYPK-DWVIGLSKINRIVSFFAQRPQVQERLTEQLLTAFQTILETDDVAVYVKATHFCVKARGIRDTN 190 Haemophilus influe...
2494695   103 HMLPFMGKVHVAYIPN-QKVVGLSKLARIVEMYSRRLQVQERLTRQIAESVQEILDPQGVAVVMEATHMCMVMRGVQKPG 181 Synechococcus sp. ...
2494697   116 HLVPFMGKVHIGYIPN-KKVLGLSKLARIVEMFSRRLQVQERLTKQIATAMVQAVQPSGVAVVIEASHMCMVMRGVQKIN 194 Caenorhabditis ele...
O13774    128 HLVPFIGKIHIGYIPR-KRVLGLSKLARIANMFSRRLQVQERLTKQVAQAIQAVLKPQGVAVVMEATHMCMVMRGVEKPG 206 Schizosaccharomyce...
9297102   166 HLVPFYGKVSIGYLPC-NKILGLSKLARIVEIFSRRLQVQERLTKQIAVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKIN 244 fruit fly
CAC28574  205 HLVPFTGKMHIGYIPS-NAVIGISKLPRIAELFARRLQIQERLTKEVANAIMEILKPQGVAVVMESSHLCMVMRGVQKTT 283 Neurospora crassa
18266889   78 HFLPFYGRAHIAYIPD-GRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPG 156 Streptococcus pneu...
Feature 1                                 
1IS8_A    203 SKTVTSTMLGVFREDPKTREEFLTLIRS 230 Norway rat
1A8R_A    192 SATTTTSLGGLFKSSQNTRHEFLRAVRH 219 Escherichia coli
1FB1_A    169 SKTVTSTMLGVFREDPKTREEFLTLIRS 196 human
1GTP_A    192 SATTTTSLGGLFKSSQNTRHEFLRAVRH 219 Escherichia coli
127481    161 AKTVTSAVRGVFKDDAAARAEVLEHIKR 188 Bacillus subtilis
1169876   191 SYTVTSAYGGVFLEDRDTRKEFLATVQK 218 Haemophilus influenzae
2494695   182 SWTVTSAMVGVFQEDQRTREEFLSLIRH 209 Synechococcus sp. PCC 7942
2494697   195 ASTTTSCMLGVFRDDPKTREEFLNLINK 222 Caenorhabditis elegans
O13774    207 SSTVTSSLTGIFQRSHKTREEFFRLIGK 234 Schizosaccharomyces pombe
9297102   245 SKTVTSTMLGVFRDDPKTREEFLNLVNS 272 fruit fly
CAC28574  284 SSTITSCVLGCFESREKTRLEFLSLIGV 311 Neurospora crassa
18266889  157 TATLTTVARGLFETDKDLRDQAYRLMGL 184 Streptococcus pneumoniae

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