2WNB,5BO8,4JS1,2WML,6APJ


Conserved Protein Domain Family
GT29

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cd19952: GT29 
glycosyltransferase family 29
Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.
Statistics
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PSSM-Id: 467690
Aligned: 56 rows
Threshold Bit Score: 136.338
Created: 12-Jul-2016
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2WNB: Sus scrofa sialyltransferase binds CMP and disaccharide, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ###                         ##                     #                        
2WNB_A        100 CAVVGNSGNlke-----syyGPQIDShDFVLRXNkAPTEGfe-aDVGsKTTHHFVYPesfre------------------ 155  pig
5BO8_A        125 CAVVGNSGIltg-----sqcGQEIDKsDFVFRCNfAPTEAfq-rDVGrKTNLTTFNPsilekyynnlltiqdrnnfflsl 198  human
Q8NDV1         80 CAIVSNSGQmvg-----qkvGNEIDRsSCIWRMNnAPTKGye-eDVGrMTMIRVVSHtsvplllknp---------dyff 144  human
XP_007513283  226 CAVVGNSGMlay-----gqnGKEIDShDVVIRFNgAPTKGle-nRVGtKTTFRLVNSkwldfr----------------- 282  Bathycoccus p...
XP_007515522  189 CAVVGSGGImvhksvaadalGEAIDKhDAVFRFNlAPTKGfe-kSVGsKTTIRLINRkhfgfr----------------- 250  Bathycoccus p...
XP_007510201  223 CAIVGNGGSlkl-----kkyGKYIDEaDAVIRFNgGPTTNglsdYVGsKTTIRFLNTqhlgfh----------------- 280  Bathycoccus p...
GBG88664      718 CAVVGNSGLsll-----yreGRNIDKhDMVIRFNkAPTRGvykqFVGsKTTFRFVNSqhigw------------------ 774  Chara braunii
XP_007509285  301 CAVVGSSGIvln-----yehGGDIDDhDMVFRFNsAPTRGfe-kHVGsKTTYRITNTqnwgfh----------------e 358  Bathycoccus p...
XP_007511275  318 CAIVGSSGIllk-----hshGADIDShDVVFRFNsATTKGfe-kNVGaKTTHRITNSrnygfr----------------- 374  Bathycoccus p...
GBG75668      352 CAVVGNSGIlsh-----yenGLKIDDhELVLRLNaARSSSfe-rQVGtRTTHRITAEqsfgfre---------------s 410 
Feature 1                                                                                         
2WNB_A        156 -laqeVSXILVPfkttdlewvisatttgrishtyvpvpakikvkkEKILIYhpAFIKYVFDRWlqgh------------- 221  pig
5BO8_A        199 kkldgAILWIPAfffhtsatvtrtl--------vdffvehrgqlkVQLAWPg-NIMQHVNRYWknkhl-----------s 258  human
Q8NDV1        145 keantTIYVIWGpfrnmrkdgngiv-------ynmlkktvgiypnAQIYVTteKRMSYCDGVFkketgkdr------vqs 211  human
XP_007513283  283 eskdeVILWNMRgagaledyi---------------krraekgkdEKFYLLssSFVNYVGEMAyqlsnsfdnlpggfnag 347  Bathycoccus p...
XP_007515522  251 efeneTSLQHTTtpdvmkqfw----------------dykslhpdLPTYPIdgSFYKYVMSDKdvan------------- 301  Bathycoccus p...
XP_007510201  281 eskkeILLQHVTveetmqkf-----------------infkkrfnGDIYVIdgDFHQLVLDTMedg-------------- 329  Bathycoccus p...
GBG88664      775 hedgeVRLQQLQsqaglmkhf----------------kyvyrhrhVKLFLFdtDFTSYVSSKVnl--------------- 823  Chara braunii
XP_007509285  359 pkteeSILIHFRaksaikglf----------------wnskqkkpLKLYAFapDFVEYVAQKVnf--------------- 407  Bathycoccus p...
XP_007511275  375 eydseCVVQHMRnemslvkmf----------------kkrakypgLNLYGVhpQLHGWVDKSFsf--------------- 423  Bathycoccus p...
GBG75668      411 wpeqvLVFVTSTqryadfls------------------qklqhpaLKLAAFhpLFMQYVTSCWpwy-------------- 458 
Feature 1             ###                 ##              ###                      #            
2WNB_A        222 grypSTGILSVIFSLHiCDEVDLYGFgad-------skgNWHHYWENNpsagaf------rktgvHDGDFESNVTTIL 286  pig
5BO8_A        259 pkrlSTGILMYTLASAiCEEIHLYGFwpfgfd-pntredLPYHYYDKKgtkftt------kwqesHQLPAEFQLLYRM 329  human
Q8NDV1        212 gsylSTGWFTFLLAMDaCYGIHVYGMindtycktegyrkVPYHYYEQGrdecdeyflhehapyggHRFITEKKVFAKW 289  human
XP_007513283  348 dytpTSGWTGLILAVNvCTEVKLYGMqise------aqgVPYHYHNRCpqp------------ygERDQAEWLMFQRF 407  Bathycoccus pra...
XP_007515522  302 -srpSNGYLGLNLALMiCDKINVYGFarnw-----kqrnMRYHYFNREepne---------sqmlRDGKGEMPLLEHL 364  Bathycoccus pra...
XP_007510201  330 --aaSNGFYGLLFGLErCEKVTLWGFakgwnkptsdrakLKYHYYDDVepne----------sqlKRDDLEAPKVAKF 395  Bathycoccus pra...
GBG88664      824 --laTGGFFGVMMALQkCARVDLYGFysr-------wytVPHHYFNHEvprsg--------krsvHDYDLEATKLKAL 884  Chara braunii
XP_007509285  408 --laTSGLYGILLALQrCHSVSIYGFqvst------qhgTLYHYYDPCdvp-----------anvERDDTEWIVIREL 466  Bathycoccus pra...
XP_007511275  424 --lvTSGLFGALIAAHkCASVDLYGFqvsr------hhgVQYHYYNAVdep-----------aneERDGDEWLAVKSL 482  Bathycoccus pra...
GBG75668      459 -fspSTGLWGVMLALQrCASVDLYGFqvsk------eygVHYNYADPCidp-----------pigQHFEMEWQILKAL 518 

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