Conserved Protein Domain Family
GT4_ALG11-like
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cd03806: GT4_ALG11-like 
alpha-1,2-mannosyltransferase ALG11 and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.
Links
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Statistics
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PSSM-Id: 340835
Aligned: 31 rows
Threshold Bit Score: 484.42
Created: 6-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P53954        72 KVFGFFHPYCnAGGGGEKVLWKAVDITLr----kDAKNVIVIYSGDFVNgenvt-----peniLNNVKAKFDYDLDSDRI 142 baker's yeast
O74878        55 RTVGFFHPYCnAGGGGERVLWTAVKSVQt----eFPNVISVVYTGDNVSka----------eiLRRVKNTFEIDLDSSKI 120 fission yeast
CAB91745     100 GIVGFFHPFCnAGGGGERVLWAAIRATQk----rWPKAKCVVYTGDHDVske---------aiLSRVEQRFNIHLHPPTV 166 Neurospora crassa
XP_001419682  23 RVIGFYHPSGgDGGGGERVLFAAIAAAQra--teGRDVTCCVYAGATSArgdepv--edgdelIARARERFGIELRAPIN 98  Ostreococcus lu...
EDP44678      49 MFVGFLHPHShGGGGGERVLYEAILHHQr----aDPNIVCVVYTGDIAPlpggv----skqemLDKVRTQFGIELNENRV 120 Malassezia glob...
XP_001700237  33 GVVAFFHPFAdGGGGGERVLWCAVKAVHd----aSKTAKVVIYCREGLSaa----------alVEDAQRRFNIRIDKPIQ 98  Chlamydomonas r...
XP_001428423  44 QTVAFLHPHCnAGGGGEKVLMCMIEKLQk-----TQKHNIVVYSAEEVDdq----------qiIEKANTRFSTHITNQDL 108 Paramecium tetr...
EAN76900      30 NAVGFLHPSAaAGGGGERVLWVAIDSIQkddiknGIDRLYVLYCTQTSGksddgrceppqeylARVVQKQFHITLPRPIK 109 Trypanosoma brucei
XP_657275     29 RTIAFFHPNCsAGGGGEMVLWVIIKVLLq----sFPNYSIVIFTADTSPkd----------kiLEKVKSTFGFDFLDCNI 94  Entamoeba histo...
XP_001305562  28 NVVTFFHPNClDCGGGEKVLWVAVDALKe----hLPEMHLFAQDATNDSa-------------QEKVNKVFKINIPSNIK 90  Trichomonas vag...

P53954       143 FFIsl-kLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCp--pDIWIDTMGYPFSYPIIARFLRriPIVTYTHYPIMSK 219 baker's yeast
O74878       121 VFVyl-kLRFLVSATTWHRFTLLGQSLGSMILGFEAIYRFa--pDIFIDTMGYAFTFCVVKSFQNi-PVGAYVHYPTIST 196 fission yeast
CAB91745     167 NFLyl-sTRRWVLASTWPYFTLAGQSFGSLIMAWDAFSLLv--pDIFVDTMGYAFALGFSRFLFRdvPTAAYVHYPTIST 243 Neurospora crassa
XP_001419682  99 VIRl--tRERWARAETYKRCTILGQFIGGAWLGLEALWTFa--pDVFVDTVGHAATYPIARYLFGc-QTVAYVHYPTVSR 173 Ostreococcus lu...
EDP44678     121 AFLpl-aYVRLVGDNFWSMFTLAGQAIGANRMGYSAMLQLv--pDVFIDTAGHAFTYSAVKNFSSrvRLGAYIHYPTIST 197 Malassezia glob...
XP_001700237  99 VVPl--rRVGLIQPERYPRLTLVRQALGSVALGWEALRQVv--pEVYIDTTGWAFPYPLAWRAGA--AVVAYVHYPTISS 172 Chlamydomonas r...
XP_001428423 109 KFIp---ILNKQLLEPKKRFTLLLQIFGQMRYALKCVNSFq--pDIFLDSTGLPFTFFIVKLLLPnvRVIAYVHYPFIST 183 Paramecium tetr...
EAN76900     110 VVHlrssMTKWLDGGRYPFLTLLLQVVCGSILLFYESCVVntmtPTVIESVGIPGVYPLLSIFAGs-RIVAYTHYPIITP 188 Trypanosoma brucei
XP_657275     95 KFYqi-kHSYSLVIKKYPFLTLFFQAIGSMICCFDALIKCn--aEYFFDTTGCAFTYPFAWLAGA--KIMTYTHYPTIST 169 Entamoeba histo...
XP_001305562  91 FVNv--gSADFIKPGYYKHFTLIFQAIGSLVYAFKCLNKEv--pAIVIDTTGAPFASIVWKLFGGc-KVILYIHYPFIST 165 Trichomonas vag...

P53954       220 DMLNklfkm-----------pkkgiKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSn----------- 277 baker's yeast
O74878       197 DMLKslkq--------------vslLAKVKMAYWRWFAQLYSDAGSHADYVMTNSSWTRNHIASLWGKd----------- 251 fission yeast
CAB91745     244 DMLEsldpasavgsqgvnagkgtgaKGRAKKIYWQLFARLYSLMGASVDVVMTNSTWTQAHIEKLWGPvrnltgavpgik 323 Neurospora crassa
XP_001419682 174 DMIArvesgrlmyn-nsrlfasskfLSGLKVLYYRAFAVVYGWCGRSCKCVMVNSSWTKSHIDALWRV------------ 240 Ostreococcus lu...
EDP44678     198 DMLQrvrqrrpght-nppqiaqslpRSMAKYVYYRLFAAVYGSALRHADVIVCNGHWTRAHVMDLLQYriprpw----rt 272 Malassezia glob...
XP_001700237 173 DMLAavwagsatavsndadiaespiKTAAKLLYYGALAGWYAGCGAVTRLAAVNSSWTRRHIAGLWRLar---------- 242 Chlamydomonas r...
XP_001428423 184 DMISqvekkearyn-nddeitksegKTKLKLWYYKFLFFFYSLCGKMTEFAYVNSTWTYNHMKQTWKSt----------- 251 Paramecium tetr...
EAN76900     189 VMTQrvengemryn-nkgavarhgvLRKAKVLYYKLFAHIYRWMGKFPDLVMTNSTWTKGHIQQLWGHd----------- 256 Trypanosoma brucei
XP_657275    170 DMLNvvqkrevsin-ntntiarssiLSTMKVFYYKIFAYLYYLVGNLASLVFVNGTWTKNHISQLWKI------------ 236 Entamoeba histo...
XP_001305562 166 DMLKavssgndqyn-nnqkiakskvLTSIKIIYYRIIAFIYSLCGYFADVITVNSTWTGNHIREIFRR------------ 232 Trichomonas vag...

P53954       278 ----TCKIIYPPCSTEKLVdwkqkf--------gtakgeRLNQAIVLAQFRPEKRHKLIIESFATFLKNLpdsv------ 339 baker's yeast
O74878       252 ---iQLSVVFPPCNTSELEkidi-------------nrkREPTLLYLAQYRPEKNHENVLRSFALYFEQHpds------- 308 fission yeast
CAB91745     324 skvnPIAVVYPPVAVEELEqevevs--------pesekrRENVLLYIAQFRPEKNHQLIVQAFAEFLKSGseaa------ 389 Neurospora crassa
XP_001419682 241 ----DSRVVYPPCNVEDLSklpltrprlnargtpvkkdkSSIRVVSVGQFRPEKAHVVQIAAWKALKKFKtlssk----- 311 Ostreococcus lu...
EDP44678     273 ptlpRLHVVYPPCQTASFTslpl-------------egrDPHSLLSIAQFRPEKEHELQLRIVHGLLQKHpelkrps--s 337 Malassezia glob...
XP_001700237 243 ---rPPVLVYPPVDTAELQtlpl------------drklKQLYLVSVNQFRPEKNHRLQLEAFAAAKRSPaaaaptlaga 307 Chlamydomonas r...
XP_001428423 252 ----QLIKLFPPCQVDAFMrrk--------------qftNQFIIISFAQFRPEKQHLLQIEIIEALVDRLpsei------ 307 Paramecium tetr...
EAN76900     257 ----VPVLVYPPCAVSHFMplrk------------lphqRINTVVSVGQFRPEKNHMLQLQSFALALPRLpt-------- 312 Trypanosoma brucei
XP_657275    237 ----QPHLLYPPCDINVSNlne--------------knsSCHLIISIGQFRPEKRHLVQIEAINILVQEHpeik------ 292 Entamoeba histo...
XP_001305562 233 ----DPIILFPPCDTTDLSklpi-------------enrIPEQIISVQQFRPEKNLPLQLEIIRRLKDTHpn-------- 287 Trichomonas vag...

P53954       340 --spiKLIMAGSTRSKQDENYVkslqdwseNVLKIPKHLISFEKNLP----FDKIEILLn-kSTFGVNAMWNEHFGIAVV 412 baker's yeast
O74878       309 ---paKLLLVGSVRGEEDMCFVnhl--ktlATELNLQSKVKFVVDAP----WPKVVEYLg-tCSIGVNYMWNEHFGIGVV 378 fission yeast
CAB91745     390 --rdaKLVLVGSVRDDYDSKRVykl--rllVNELHIKDRVEFHLDAS----WPDILEWLr-rASVGVNGMWNEHFGIGVV 460 Neurospora crassa
XP_001419682 312 -ienaILVFVGGCRDEADRERLadl--qqsVKDLELQDSVQFHVDVS----YDEVKRELs-rASIGLHSMIDEHFGICVV 383 Ostreococcus lu...
EDP44678     338 sgralRLTLIGSCRHDADKKRLval--erlAKELMIENHIEWCVDAP----FTTMIDKMr-tASIGLSTMVDEHFGIAVV 410 Malassezia glob...
XP_001700237 308 alreaRLKLVGGVRGPADEARLagl--kayAAELGIADSCEWIVNAP----FSELRQLLg-gAVAGLHTMTDEHFGISVV 380 Chlamydomonas r...
XP_001428423 308 -sqsiKLYMIGSCRNADDDLLFeti--qdtINKKNLQDYISMHKNLP----FQDIQKFLt-sGMIGLHTMEYEHFGITLV 379 Paramecium tetr...
EAN76900     313 ---daKLIMIGGARNEEDKQRAeav--kveAQRLGIADRVDVRVGAP----FSEVSESLa-qCCIGLHTMEDEHFGIVLV 382 Trypanosoma brucei
XP_657275    293 --nkiKFVVIGGARDAEDLKRKe------eVIKTIEKDKLTDIITVPestsYEQKIEYLk-nAEIGLHTMVNEHFGICVV 363 Entamoeba histo...
XP_001305562 288 ----mKLYIIGGCRNEADKKLLdg----lqEEIDRDKLPITLVPNCD----FDILRNEYfarSSVGLHTMYNEHFGICAV 355 Trichomonas vag...

P53954       413 EYMASGLIPIVHASAGPLLDIVtpw------------------------------------------------------- 437 baker's yeast
O74878       379 EYMAAGLIPVVNNSGGPKFDIVipw------------------------------------------------------- 403 fission yeast
CAB91745     461 EYQAAGLISVVHDSGGPKLDIVvev------------------------------------------------------- 485 Neurospora crassa
XP_001419682 384 EYMAAGAVPVAHASGGPFLDIIrdq------------------------------------------------------- 408 Ostreococcus lu...
EDP44678     411 EYMAAGLLTLSHASAGPLMDIAvpv------------------------------------------------------- 435 Malassezia glob...
XP_001700237 381 EYMAAGCVPIAHNSAGPKMDIVlpllldaqgaaalaaaaglgrggsdslggcggadgllgpaadsplvldagahvspaga 460 Chlamydomonas r...
XP_001428423 380 EMLAAGLIVVAHNSAGPKLDILa--------------------------------------------------------- 402 Paramecium tetr...
EAN76900     383 EYIACGCIPLGHRSGGVCLDIIt--------------------------------------------------------- 405 Trypanosoma brucei
XP_657275    364 EYMGFGVIPVAHKSAGPELDIVd--------------------------------------------------------- 386 Entamoeba histo...
XP_001305562 356 EYLAAGLIPLCNKSAGPLYDIV---------------------------------------------------------- 377 Trichomonas vag...

P53954       438 ------------------danGNIGKAPPQWELQKKYFAKLEDDGETTGFf---fKEPSDPDYNTTKDPLRYPN 490 baker's yeast
O74878       404 -------------------igKPTGFHASTISEYAEAYHKALTLSPQEQLe---mRINARSACARFGEHVFMRD 455 fission yeast
CAB91745     486 -------------------dgEPTGFHATTSKEFAEGFEKALSLPNPYAV-----RLRARKSAKRFTEEEFARR 535 Neurospora crassa
XP_001419682 409 -------------------hdGPTGFTADSVATFAETLEHLLLMRRTEREe---iSARARARSDIFSETEFNSN 460 Ostreococcus lucimari...
EDP44678     436 -------------------sgMQTGFHASCLDEYIDTAYRLMTMPPSTALkv--rRIARERAASSFSDVEFHRR 488 Malassezia globosa CB...
XP_001700237 461 agagtcqaggggggavgggavQVTGFLATTVDEYAEAIIKVLTMDQRERLr---vAAAAQRQAGRFSTERFLQD 531 Chlamydomonas reinhar...
XP_001428423 403 ---------------------NDVGFLCENLEDYVLSIVRIMQLTDEDRSr---yQLMGRKQAVNFSDESFKDL 452 Paramecium tetraurelia
EAN76900     406 --------------------sPNVGFLAATAEEYADCMAEIFRIKNDEPEtyrkfQECGMATIARFSDESFGEK 459 Trypanosoma brucei
XP_657275    387 ---------------------DQCGYLATTPKEYADAIFKIINDPEKTAQm----RQAAIQKAKKFSVSAFEKQ 435 Entamoeba histolytica...
XP_001305562 378 ---------------------KDENYLALTADEYAAKLEVAFKCDDSARLqf--rNSCSRFSYEEFSKQFIAAV 428 Trichomonas vaginalis G3
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