5HCI,1YR6,2OXR,5HCN


Conserved Protein Domain Family
GPN1

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cd17870: GPN1 
Click on image for an interactive view with Cn3D
GPN-loop GTPase 1
GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.
Statistics
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PSSM-Id: 349779
Aligned: 40 rows
Threshold Bit Score: 291.009
Created: 7-Aug-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5HCI; Saccharomyces cerevisiae GPN-Loop GTPase Npa3 with bound MgGDP, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ########                                                                 
5HCI_A         3 STIICIGMAGSGKTTFMQRLNSHLRaek---------------tpPYVINLDPAVLRVPYganIDIRDSIKYKKVMEnyq 67  baker's yeast
1YR6_A        15 MIVVFVGTAGSGKTTLTGEFGRYLEdn----------------ykVAYVNLDTGVKELPYepsIDVREFVTVEEIMRe-g 77  Pyrococcus abyssi
2OXR_A        15 MIVVFVGTAGSGKTTLTGEFGRYLEdn----------------ykVAYVNLDTGVKELPYepsIDVREFVTVEEIMRe-g 77  Pyrococcus abyssi
XP_657116     11 INVILVGMAGSGKTTLMSILAEKTD--------------------AYLINLDPACNDPPYspdIDIRDTVNYKEVMKdyg 70  Entamoeba histo...
AAZ32449       3 ANLFVVGPAGSGKSTFTAAFREWMIkne---------------ydTVIVNLDPGADSLPYtpdLDVRDVLSLEDVMSeyg 67  uncultured eury...
XP_001431081  12 VAILIIGMAGTGKTTFVQQLSKQLKne-----------------kHTLINLDPAVYSLPYepeEDIRKSINYKELMTknk 74  Paramecium tetr...
XP_001584461   7 AAVLVVGLAGSGKSTLMNALNQYTYdnk---------------kmTYYVNLDPATADVDFsanVDIRDTVKYGEVMQkfn 71  Trichomonas vag...
XP_001713558   7 FTLFIIGMAGSGKSTLVNNLSKEFSnnn---------------hkNFIINLDPASKNLNYipnIDIRDTVDYKKVMRiyn 71  Guillardia theta
EES99487      27 PVLLVIGMAGAGKTTFVQRLVAELNqrqaayalrprirqeiiakePYVINLDPAALDTPYtpsVDIRDTFNIGDLMKkhh 106 Giardia intesti...
XP_003075083   8 NVYVVVGMAGAGKTSFLERVATYLErsg---------------kpPYIINLDPAAMRLPYdanIDIRDTVDYKSVMSeyc 72  Ostreococcus tauri
Feature 1                                                                                        
5HCI_A        68 LGPNGAIVTSLNLFstkidQVIRLVEQKKdkfQNCIIDTPGQIECFVWSaSGAIITESFAssfptVIAYIVDtprns-sp 146 baker's yeast
1YR6_A        78 YGPNGAIVESYDRLmekfnEYLNKILRLEkenDYVLIDTPGQMETFLFHeFGVRLMENLPy---pLVVYISDpeilk-kp 153 Pyrococcus abyssi
2OXR_A        78 YGPNGAIVESYDRLmekfnEYLNKILRLEkenDYVLIDTPGQMETFLFHeFGVRLMENLPy---pLVVYISDpeilk-kp 153 Pyrococcus abyssi
XP_657116     71 LGPNGAIVTSLNLYstkvdQLVTVLQNKQ---QLTFIDTPGQIEVFTWSaSGQVISEALSivaptIYLYVVDtarcvenp 147 Entamoeba histo...
AAZ32449      68 LGPNGAQVVAADLLanyvdEIKRDVDSYEs--DYVIYDTAGQLELFAFRaASTFLVDYLGek-raMLAFMFDpalak-tp 143 uncultured eury...
XP_001431081  75 LGPNGAIMTALNLYslqlnQLIEKIEKSDs--NIQIIDTPGQIEVFTWSaSGNLISQTLSmsmptIIFYVIDiarcq-np 151 Paramecium tetr...
XP_001584461  72 LGPNGAILTSLNLFstkfhEVVSLIQKRKd-lEYAIFDTPGQIEAFAWSaSGGMITQELAaafptVVVFVVDvprct-kt 149 Trichomonas vag...
XP_001713558  72 LGPNGAIMASLNLFstrfdQIQKIIKKNSskiEFIIIDTPGQLEVFTWSaSGSIITECFLsnspvLILYVIDlskil-np 150 Guillardia theta
EES99487     107 WGPNGAIMTTLNLFatkidELDNLMRKKAertSCYVFDTPGQIEVFTWSsSGEIISKFFGsayptILLYVVDsercl-sp 185 Giardia intesti...
XP_003075083  73 LGPNGAILTSANLFatrfdKVVSICDLRAqdyEYFFIDTPGQIEIFTWSaSGIMITDMLSahfrtTILFILDtpqcq-np 151 Ostreococcus tauri
Feature 1                                 ## ##                                                  
5HCI_A       147 ttFMSNMLYACSILYKtklpMIVVFNKTDVckad-----------fakEWMTDFESFQAAIKEDqdg------ymSSLVN 209 baker's yeast
1YR6_A       154 ndYCFVRFFALLIDLRlgatTIPALNKVDLlseee--------kerhrKYFEDIDYLTARLKLDps-------mqGLMAY 218 Pyrococcus abyssi
2OXR_A       154 ndYCFVRFFALLIDLRlgatTIPALNKVDLlseee--------kerhrKYFEDIDYLTARLKLDps-------mqGLMAY 218 Pyrococcus abyssi
XP_657116    148 ntFMANMTYACSILYKtklpLIIVFTKTDVipct-----------klnQWMDDYDNYLDALNETes-------yaSDLQR 209 Entamoeba histo...
AAZ32449     144 sgFVSLLLLSATVHFRfyrpYINILSKVDLleddv--------leniaAWSENWDRLYGALIEDspg------myRELNV 209 uncultured eury...
XP_001431081 152 nsFMSNLLFSCSIFYKfklpMVIVFNKCDVadsk-----------qplEWLRNYDSFTEALKNKdt-------ylSTLSK 213 Paramecium tetr...
XP_001584461 150 ptFISTMLYACSILYRsglpMVMALTKTDVkpaq-----------eiiDWMTDEDKFNAAIDSEndg-----syfTDFNR 213 Trichomonas vag...
XP_001713558 151 inFTTNILYSCSTLYKtkipSLTLVNKIDItsid-----------ffiEWYCDSNNLDTSFQENgl-------fiESFRR 212 Guillardia theta
EES99487     186 itFVASMLYCCSIMERlelpVIIVFNKSDLispslsvepdalsrwapwVYIRNNIALSDAFNDLqernvnsiaysDIFYE 265 Giardia intesti...
XP_003075083 152 qiFMSNMLQAVSVLYRsrlaVILVFNKIDVasha-----------plvKLLSDMSLFQSELEGVsd-------fsSTLTQ 213 Ostreococcus tauri
Feature 1                          ###              
5HCI_A       210 SMSLmleeFYSQLDVVGVSSFtgDGFDEFMQCVDK 244 baker's yeast
1YR6_A       219 KMCSmmteVLPPVRVLYLSAKtrEGFEDLETLAYE 253 Pyrococcus abyssi
2OXR_A       219 KMCSmmteVLPPVRVLYLSAKtrEGFEDLETLAYE 253 Pyrococcus abyssi
XP_657116    210 SLCLalddFYKNILHCGVSSKtgEGVDKLLECIQE 244 Entamoeba histolytica HM-1:IMSS
AAZ32449     210 EVFKalesMDVFKKLIPTSARmlYGYEDIYTAIQM 244 uncultured euryarchaeote Alv-FOS1
XP_001431081 214 QMVLtleeFYNNFTVLEVSSLtgQGFEKINEVIAT 248 Paramecium tetraurelia strain d4-2
XP_001584461 214 ATGSifseFYNAIPVIPVSGRtgEGVKELLAKIDE 248 Trichomonas vaginalis G3
XP_001713558 213 SLSLvldsFNQKIIYIGISSLknIGLTKINNYINK 247 Guillardia theta
EES99487     266 SLSTileeFYNVIDYVNVSSYtgVGFEGLLDKIRK 300 Giardia intestinalis ATCC 50581
XP_003075083 214 SLHLilqeFYEHLKIVGVSAAtgSGVEEVISVLED 248 Ostreococcus tauri

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