2VT4,4IB4,3PBL,3RZE,3UON,4IAQ


Conserved Protein Domain Family
7tmA_amine_R-like
?
cd14967: 7tmA_amine_R-like 
Click on image for an interactive view with Cn3D
amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Links
?
Statistics
?
PSSM-Id: 320098
Aligned: 77 rows
Threshold Bit Score: 182.378
Created: 10-May-2005
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
  next features
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2VT4: Meleagris gallopavo beta-1 adrenergic receptor binds high-affinity antagonist cyanopindolol, contacts at 4A.
  • Structure:4IB4: Human serotonin receptor binds ergotamine, a hallucinogen lysergic acid diethylamide precursor, contacts at 4A.
  • Structure:3PBL: Human dopamine D3 receptor binds with selective antagonist eticlopride, contacts at 4A.
  • Structure:3RZE: Human histamine H1 receptor binds antagonist doxepin, contacts at 4A.
  • Structure:3UON: Human M2 muscarinic acetylcholine receptor binds antagonist 3-quinuclidinyl-benzilate, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                    #
2VT4_A     13 GMSLLMALVVLLIVAGNVLVIAAIGSTQRlq-tlTNLFITSLACADLVVGLLv---VPFGATLVVrgtwl-wgsflCELW 87  turkey
EDV21073   39 TSLAIQISIVVLSVICNSLVIATIVGYRRlh-nnTNYLVVNQCVVDFLFATLiiavYPIQALLGYwpfi----kewCAIH 113 Trichoplax adhaerens
EDO46247   18 VISTSYVLVMVASLAGNLLICITIYKNKVllkspCYYFILSLALSDLGTTLFa---MPFDLEQVLtngkwthshhlCNVW 94  starlet sea anemone
EDV21892   41 FKTVYIFTVFITGIICNAIVIATIAYNRQlh-svTNYFIVSQCCADFLFAALv---LPAYCLQGLlgywp-fmpewCAIH 115 Trichoplax adhaerens
EDV21993   45 IVIGFSLAVVIISVVCNVIVIATILCNRFlr-ttTNYFMISQSIADLLFALIv---ILGMVIQALlgywp-fapfwCAIY 119 Trichoplax adhaerens
EDV19462    2 TFVCITLSIFVVSFAANLIVAGTILCRKHlr-niTHLFVFNQCIADLIRVSLq---IPPLVVNMLlgywp-fgpvyCNLS 76  Trichoplax adhaerens
EDO41063    9 LQVTFLALVILIAVVANGFVCLVIYKTPAlh-nvINMFLVSMSISDLLHAILk---MSTTLVSTLyrdwy-phkaiCYVT 83  starlet sea anemone
EDO39710   30 LFTLLYISASVIGSFANIGILLAFFTMRKlr-trINYFLASLAVSDLVMLTIy---LPFEIEWHVrtffk-hsatvCDFV 104 starlet sea anemone
EDO34172    2 VVSMYEILVIIFAVTGYALVTFAMVLNPRlr-niCNYFILSMGLADALIVIVi---VPVNLGLMLdtlky-dsvtaCEFV 76  starlet sea anemone
EDO43219  105 LLIAYFATIMALGLSMNICVIATILQARRlr-tvTNTFVLSLALADLLMAAVv---IPLQIHDVLqpr------vlSHLL 174 starlet sea anemone

Feature 1        ##  ##                                                                       
2VT4_A     88 TSLDVLCVTASIETLCVIAIDRYLAITSPfryq---slmtRARAKVIICTVWAISALVSFLPimmhwwrdedpqalkcyq 164 turkey
EDV21073  114 YCLSIGLVMVSILNLCAISFDRYIAICHPyhhp---rlmtKKSLIIILLFVWIQPLLISLLPimlwrthhdlpfg--ics 188 Trichoplax adhaerens
EDO46247   95 TTAYLVTVPTSILHLLTLSIERYKTLNDPldrykespfltVKRAMLVIVVIWAYSFVFALIPvmgwrafpqsn------a 168 starlet sea anemone
EDV21892  116 ACLSISLVMTSLLNLFAISLDRYLAICRPyqyh---twmtTRFVIGMLLYIWFQPLLLALIPvfgwrgvqstigs--hcv 190 Trichoplax adhaerens
EDV21993  120 NACGIGLVMVSILNFCAISIDRYIAICYPflqh---rlnfTLLFILASAYIWMQPIILSLLPmviwhdytqvdi----nv 192 Trichoplax adhaerens
EDV19462   77 YPITIFLMSVSILNVCSISIDRYFSITSPllyqa-rqimsKKIVLVLLLFVWLEPLVIALLPmfvwrdigydprp-gscf 154 Trichoplax adhaerens
EDO41063   84 TPFGVLFGAASVFNLCAVAVNQYFVIVKPlhyp---llmtYTHARRVITALWLGSIVISTPPifwrsakticr-----sg 155 starlet sea anemone
EDO39710  105 YTLFFITISSSCLNLMAVSGYRFFTIAYPfwsk----kitKTHVFYCIAIIWFYSCMTALLPvmgwrdrpsq-------v 173 starlet sea anemone
EDO34172   77 SSINLIAIVAVSLNLCSVSLERFLVIQFPfgye---afltQRKAIAMIFGLWVYAILVGLLPqmgwtngktyi------s 147 starlet sea anemone
EDO43219  175 DPLFPILGVASLLNLCAVTLDRFFTITRPltye---akvsPRRVGIIIACIWLISIAQEAVRfsir-------------- 237 starlet sea anemone

Feature 1                  #  ##  #                                                           
2VT4_A    165 dpgccdfvtNRAYAIASSIISFYIPLLIMIFVALRVYREAkeqirkidr---------------------------askr 217 turkey
EDV21073  189 ydinrsliqERVYLASFLMINYVIPAFIMLLLYSLIFRTAcrqvhqinkqnmis-----------------ssslsdsir 251 Trichoplax adhaerens
EDO46247  169 vtevcgfniSPAYSALSSVLNFFLPMFVMCLVYYKIYTIAnkqrkvpllrpsdkshdkelhsvgarissnmstyiaarsr 248 starlet sea anemone
EDV21892  191 vdlflyikqERIYLLIITLINFYIPATIMFTLYILIFKVAirhihnieqqrnvqrkqh----------yfgsiqdqlnhr 260 Trichoplax adhaerens
EDV21993  193 cghvithtrEKIYFLILVIANIFLPALLLSVLYSIVFKTAcghiqkikqqnslh-----------------rqlsraadi 255 Trichoplax adhaerens
EDV19462  155 vqwtaapsfERPYLVCLMVVNFFVPCLAMSMIYARIFVIAskhakrvkyessa--------------------ysieast 214 Trichoplax adhaerens
EDO41063  156 avsqqdyisEVCYIGALWTFVIFIPSVVMTWAYSNIYVTArnqikrmrlqn------------------------gvsgg 211 starlet sea anemone
EDO39710  174 inkmcwfqyKPEFIVFLMGINWMLPALVVFVCYAMILRIAriqaqkiaksqv---------------------lgalsdr 232 starlet sea anemone
EDO34172  148 shgscrrplSDDYLIFSTVAHFCIPAAIMIVSNILVYRVAttqarrifkikiqask--------------taacvydeqp 213 starlet sea anemone
EDO43219  238 -----edhpEQIFQVVRFALVFSVPFTCVLFVNVKIYVIArahsrqiaand-----------------------pnldgr 289 starlet sea anemone

Feature 1                              #  ##  #                         #   #   #             
2VT4_A    218 krvmlMREHKALKTLGIIMGVFTLCWLPFFLVNIVNvfnr-----------dlvPDWLFVAFNWLGYANSAMNPIIYCRS 286 turkey
EDV21073  252 thktsDKDIKLVLLFLAIVGTLYICWTPLYTLMMISyfdv-----------fyqPHIGTFVAIMLAFSNCAINPIIYSCS 320 Trichoplax adhaerens
EDO46247  249 klkvfLRDTRAARTIALIVCSFFCCWMPHTVFSFVSvccra--------cgsaaPEELQCVLLLLGYLSSAINPYLYSCQ 320 starlet sea anemone
EDV21892  261 ylrlaKNDFRLILVFVVVNGAFYLCWTPFMTFGLISlfhl-----------gpvTDNLGIACSLMAFTNCTLNPIIHNFF 329 Trichoplax adhaerens
EDV21993  256 krpitSKDFKLLLIFVFIIGTFYLTWTPFFVVLIINyfdddpy-----hpsregFRFFSSIAILISFTHCAINPIAYNFM 330 Trichoplax adhaerens
EDV19462  215 raridAKDIRIIAVLATIVGFFLICWLPFFINGLVLlfsp-----------rlmSTVLYTASVYLSFANAAINPLIYAIF 283 Trichoplax adhaerens
EDO41063  212 itktrKKELRVAALLALIGGIFIICWVPFFIVMTLVkfsd-----------isvDREYFKIFLFVMYAKSAINPLLYTVM 280 starlet sea anemone
EDO39710  233 erkrnRHQLRGAISLAKIVAVYLVCWLPYIIIGFVGqlnq----------tfsiPREGNYLIIFLVYSNATINPFLYAGL 302 starlet sea anemone
EDO34172  214 itevfRMNYRAAKRVSIIVGTYLICWFPQMSVLLVGlhig----------yrsiPPAVFPITLALQYTSSAVNPCIFCFM 283 starlet sea anemone
EDO43219  290 strsfAKKLKTARIIGLLVGTFVLTWLPFFVMTVCEifiklslpkqevlvharkLKIGNTVCAALASSTAFFNPLLYGLM 369 starlet sea anemone

Feature 1             
2VT4_A    287 Pd-FRKAF 293 turkey
EDV21073  321 NapIRKGL 328 Trichoplax adhaerens
EDO46247  321 VsdMRRAY 328 starlet sea anemone
EDV21892  330 NreIRSGF 337 Trichoplax adhaerens
EDV21993  331 NseMRRGL 338 Trichoplax adhaerens
EDV19462  284 TrdIRHQI 291 Trichoplax adhaerens
EDO41063  281 NydLKLSC 288 starlet sea anemone
EDO39710  303 CedFKEAF 310 starlet sea anemone
EDO34172  284 NreLKATL 291 starlet sea anemone
EDO43219  370 RkeVREAM 377 starlet sea anemone

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap