2YBX


Conserved Protein Domain Family
PIPKc_PIP5K2A
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cd17309: PIPKc_PIP5K2A 
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Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP5K2A) and similar proteins
PIP5K2A (EC 2.7.1.149), also known as PIP4K2A, or 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, or diphosphoinositide kinase 2-alpha, or PIP5KIII, or phosphatidylinositol 5-phosphate 4-kinase type II alpha, or PI(5)P 4-kinase type II alpha, or PIP4KII-alpha, or PtdIns(4)P-5-kinase C isoform, or PtdIns(5)P-4-kinase isoform 2-alpha, catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), one of the key metabolic crossroads in phosphoinositide signaling. It is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. PIP5K2A is associated with schizophrenia. It controls the function of KCNQ channels via phosphatidylinositol-4,5-bisphosphate (PIP2) synthesis, and plays a potential role in the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors.
Links
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Statistics
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PSSM-Id: 340446
Aligned: 7 rows
Threshold Bit Score: 574.619
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2YBX_A        16 ENLYFQsmDPLLSVLMWGVNHSINELSHVQIPvMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFg 95  human
NP_001122174  26 KVKLFRasDPLLSVLMWGINHSINELSHVQIPiMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPLVFRNLRERFv 105 zebrafish
XP_007887985   8 KFKLKCncIDFRKNFIVFCFLQINELSHVQIPvMLMPDDFKAYSKIKMDNHLFNKENMPSHFKFKEYCPMVFRNLRERFg 87  elephant shark
Q5F356        26 KVKLFRasDPLLSVLMWGVNHSINELSHVQIPvMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFg 105 chicken
NP_001123723  26 KVKLFRasDPLLSVLMWGVNHSINELSHVQIPiMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFg 105 western clawed ...
P48426        27 KVKLFRasDPLLSVLMWGVNHSINELSHVQIPvMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFg 106 human
XP_014347749 218 KPVGVQs-QYRMCHQHSGEWWNINELSHVQIPvMLMPDDFKAYSKLKVDNHLFNKENMPSHFKFKEYCPTVFRNLRERFg 296 coelacanth

Feature 1                                              #                                         
2YBX_A        96 iDDQDFQNSLTrsAPLPNDsqarsgARFHTSYDkRYIIKTItSEDVAEMHNILKKYHQYIVECHgitlLPQFLGMYRLNV 175 human
NP_001122174 106 iDDQDFQNSLTrsAPLVSEaqgrsgARFHTSYDkRYVIKTIsSEDVAEMHNILKKYHQYIVECHgstlLPQFLGMYRLTV 185 zebrafish
XP_007887985  88 iDDQDFQNSVTrsAPFSNDsqgrsgARFHTTYDrRYVVKTIsSEDVAEMHNVLKKYHQYIVECHgntlIPQFLGMYRLTV 167 elephant shark
Q5F356       106 iDDQDFQNSLTrsAPLANDsqarsgARFHTSYDkRYIIKTItSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRLTV 185 chicken
NP_001123723 106 iDDQDFLNSLTrySPLANDsqarsgARFHTSCDkRYIIKTItSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRLNV 185 western clawed ...
P48426       107 iDDQDFQNSLTrsAPLPNDsqarsgARFHTSYDkRYIIKTItSEDVAEMHNILKKYHQYIVECHgitlLPQFLGMYRLNV 186 human
XP_014347749 297 iDDHDFQNSLTrsSPFTNDsqgrsgARFHTTYDkRYVIKTIsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRLTV 376 coelacanth

Feature 1                                                                                        
2YBX_A       176 dGVEIYVIVTRNVFshrLSVYRKYDLKGstvareasdkekakelPTLKDNDFINEgqkiyiddnnKKVFLEKLKKDVEFL 255 human
NP_001122174 186 dGDETYMIVTRNVFshrLSVYKKYDLKGstvareasdkekakelPTYKDNDFINDgqkiyiddesKKIFLNKLQKDVEFL 265 zebrafish
XP_007887985 168 dGVETYMIVTRNVFghrLSVYRKYDLKGstvareasdkekakelPTLKDNDFINNgqkiyidennKKMFQEKLRKDVEFL 247 elephant shark
Q5F356       186 dGVEIYMIVTRNVFshrLSVYRKYDLKGstvareasdkekakelPTFKDNDFINDgqkihidennKRMFLEKLKKDVEFL 265 chicken
NP_001123723 186 dGVETYMIVTRNVFshrLSVYRKYDLKGstvareasdkekakelPTYKDNDFINDgqkiyidennKKLFLEKLKKDVEFL 265 western clawed ...
P48426       187 dGVEIYVIVTRNVFshrLSVYRKYDLKGstvareasdkekakelPTLKDNDFINEgqkiyiddnnKKVFLEKLKKDVEFL 266 human
XP_014347749 377 dGIETYMIVTRNVFshqLSVYRKYDLKGstvareasdkekakelPTFKDNDFINEgqkiyideknKKMFLEKLKKDVEFL 456 coelacanth

Feature 1              #                                                                         
2YBX_A       256 AQLklmDYSLLVGIHDVeraeqeeveceendgeeegesdgthpvgtppdsp----gntlnsspplapgefdpnidvygik 331 human
NP_001122174 266 ALLklmDYSLLVGIHDVeraeqeevesednegeeegesdggivgtppdsps-----ntldstkplspgdfdpnidvyaik 340 zebrafish
XP_007887985 248 AQLkimDYSLLVGIHDVeraeqeeiefeendeeegesdgagahttgscgtppdspgnilnssrplapgefdptidvyaik 327 elephant shark
Q5F356       266 AQLklmDYSLLVGIHDVeraeqeeveceendgedegesdgthpigtppdsp----gntlnsslplapgefdpaidvygik 341 chicken
NP_001123723 266 AQLklmDYSLLVGIHDVeraeqeevesedndgeeegesegthpvgtppdsp----gntlnstkplppgefdpaidvygik 341 western clawed ...
P48426       267 AQLklmDYSLLVGIHDVeraeqeeveceendgeeegesdgthpvgtppdsp----gntlnsspplapgefdpnidvygik 342 human
XP_014347749 457 AQLklmDYSLLVGIHDVeraeqedieceendgedegesdgthpvgtppdsp----gnalnnlrpmtlgefdpaidvyavk 532 coelacanth

Feature 1                        #                                            
2YBX_A       332 chensprkeVYFMAIIXILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLDFIGH 392 human
NP_001122174 341 shdnsprkeVYFMAVIDILQhYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFYDFITT 401 zebrafish
XP_007887985 328 shensprkeVYFMGIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLDFIAS 388 elephant shark
Q5F356       342 shesaprkeVYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLDFIAN 402 chicken
NP_001123723 342 chdnaprkeVYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLDFINN 402 western clawed frog
P48426       343 chensprkeVYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLDFIGH 403 human
XP_014347749 533 shensprkeIYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRLLDFITS 593 coelacanth

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