2MGY


Conserved Protein Domain Family
TspO_MBR

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pfam03073: TspO_MBR 
TspO/MBR family
Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.
Statistics
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PSSM-Id: 460795
Aligned: 425 rows
Threshold Bit Score: 30.6379
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MGY_A               11 LTLVPSL-GGF--MGAyfvrg-------eglrWYAGLQK-------PSW-HPPRWTLAPIWGTLYSAMGYGSYIVWKELg 72  house mouse
goetting:Awo_c17880  11 LNLGFLVlTLVinTMGav-------------gLFNNLSQkdvsdlySTLiTPAPFTFSI-WSIIYLLLFIATIMMIVKHn 76 
CAQ00213             15 AFAVIGSaFGSgaFSDrsiqnassgalsasytPV----------------APAGPAFSI-WSVIYL--GLVAYTIWQALp 75 
CeBiTec:CGLY_15670   29 ATAV--AfLGAgvVGGtpvaeaaggwlgqdatPL----------------APATPAFRI-WSVIYV--GLLAYSVWQVLp 87 
WP_012865540         18 VVAIFGAaWGAgaFGGtptseaadgalsasatPV----------------APGTTAFSI-WSVIYV--GLIAYAVWQALp 78  Sanguiba...
WP_012958091         15 AVLIVNYlSNAlpINGqtagei----sdrlnvMF----------------TPAGYVFSI-WGFIYL--LLVIWVGAQFFp 71  Alkaliha...
jgi:Nther_0915       20 LVLIVNFlSNYipFNNltqedi----teiypvLI----------------TPAGYVFSI-WGIIYL--LLIGFIIYQALp 76 
WP_015077919         20 AMVAVNAlANIlpFNGmntgei----snlynvLF----------------TPAGYVFSI-WGVIYI--AVFIWL---VNl 73  Carnobac...
WP_014823755         13 AVIVVNVlSNTlpLNGqtasei----tnrlevLF----------------TPAGYVFSI-WSLIYG--LLVLWL-ITIYr 68  Solibaci...
WP_013942775         17 IILVIELfMAIvlQKGfs-------------aYYNSFHH-------LDW-VLPRYLSIPIWSIMYILYAIAGASIWIKRk 75  Simkania...
2MGY_A               73 gftedamv--plglytgqLALNWAWPPIFFGARQMGWALADLLLVSGVATATT-LAWhRVS-------------PPAARL 136 house mouse
goetting:Awo_c17880  77 dpyykeainkisvlfwisCLLNCLW-IICFSYTQIGLSAIVIFVFLITLTYIIrQIG-AIQtrq-------rwlLAATFG 147
CAQ00213             76 aqraderqrrvgypvavtLVLNAAW-ILTAQAGFLVLSGVVIVALLLTLIWTFrTLM-ATRprnlve-gvvldgTMGL-- 150
CeBiTec:CGLY_15670   88 sqrrssrqrrlrpwavaaMLLNAAW-IWSVQLDQLTLSLVVIVVLLGVLVRVLvLTV-ETPpetrvg-avladgTFGL-- 162
WP_012865540         79 sqresarqrsmgwlaalsMLLNAGW-LLVVQAGSVWASVVVMAALLTTLVMILeRMR-ATPssslve-tvlvdgTFGL-- 153 Sanguiba...
WP_012958091         72 ktknnpvyekvglwfvisCVFNIAW-LLLFHYEFFNLTMVAMAALLISLIVIYiRMD-GVKdpsk------friPFSV-- 141 Alkaliha...
jgi:Nther_0915       77 syretpkvsavgilfavtALLNILW-LFAWHYLQIGLSMVLMILLLITLIGIYkKII-GRKssetffdwlfvrlPFSI-- 152
WP_015077919         74 slnkepirkisaslfilsCLLNGSW-IFFWHYQFVGTSVFVITALFITLLLLYlYER-GQKgl---------vwPFSI-- 140 Carnobac...
WP_014823755         69 kvkdnrfkgkvgilfiisCIFNIAW-LFSWHYEQFILSIIVMFFLLFTLIAIYlQYK-NTEkgls------erfPFSF-- 138 Solibaci...
WP_013942775         76 sfirkya----laswvivIFLNILWPITFFYIPLRILTPIILSVLFISLLALLfYSF-LAS-------------RLAGYL 137 Simkania...
2MGY_A              137 LYPYLAWLAFATVLNYYV-WR 156 house mouse
goetting:Awo_c17880 148 M--YTGWLLIATVLNISAwFV 166
CAQ00213            151 ---YLGWVSVATIANITSiLT 168
CeBiTec:CGLY_15670  163 ---YLGWVTVATVANVAAvLA 180
WP_012865540        154 ---YLGWVTVAAIANVAAaIT 171 Sanguibacter keddieii
WP_012958091        142 ---YLGWVSVATIVNVGIvLT 159 Alkalihalobacillus pseudofirmus
jgi:Nther_0915      153 ---YLAWISVATLANLNIlLN 170
WP_015077919        141 ---YLGWVTVATLANISYyLV 158 Carnobacterium maltaromaticum
WP_014823755        139 ---YLAWISVATIANVSYvLK 156 Solibacillus silvestris
WP_013942775        138 LIPITFMILYLLLLHWTLfII 158 Simkania negevensis
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