Conserved Protein Domain Family
PAP2_glucose_6_phosphatase
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cd03381: PAP2_glucose_6_phosphatase 
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.
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Statistics
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PSSM-Id: 239476
Aligned: 12 rows
Threshold Bit Score: 274.259
Created: 3-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             #      #                                 
AAH76446    38 TFFVFFPVWFh----LRRDVAVKLIWVAVVGDw-LNLVLKWVLFGERPYwwvhetkfygpmkh---pelqqfsmtcetgP 109  zebrafish
NP_066999   38 IFFIYFPLCFq----FNQTVGTKMIWVAVIGDw-LNLIFKWILFGHRPYwwvqetqiypnhss---pcleqfpttcetgP 109  human
AAH45085    42 TFLILFPIWFh----LSESVGVKLVWVAVIGDw-LNLVFKWILFGQRPYwwvhettffvnssa---ptilqfpvtcetgP 113  African clawed frog
AAP92612  1226 VEQSLPEIAGgdekpDLTSRCKEHIPEDVRVD--RFQCGMLILFGQRPYwwvldtdyysnssv---plikqfpvtcetgP 1300 Norway rat
CAG06568    38 AFLLVFPLTYf----ISKRTGIAVLWVAAISEw-LNLVFKWMLFGERPFwwigeshlfdnnl----pkvqqfpstcetgP 108  Tetraodon nigrov...
P35575      42 AFYVLFPIWFh----LQEAVGIKLLWVAVIGDw-LNLVFKWILFGQRPYwwvldtdyysntsv---plikqfpvtcetgP 113  human
XP_418136   42 TFFVLFPIWFh----LCEPVGIRLIWVAVIGDw-LNLVFKWILFGERPYwwvhetdyysna------sapaiqqfpltcE 110  chicken
XP_582153    1 MEKGMNVLHDf----GIQSTHYLQVNYQNSQDw-FILVSVIADLRNAFYv-----------------------------L 46   cattle
AAH21574    38 LFLFYFPAAYy----ASRRVGIAVLWISLITEw-LNLIFKWFLFGDRPFwwvhesgyysqap----aqvhqfpsscetgP 108  human
EAA12723    41 LFLTVIPVVA-----GLSTTLYSKLLLSVLLTeyANTIVKWILAEDRPFwwlnetkefsslnr---pkiyqneltcepsP 112  Anopheles gambia...
EAL33224     1 LFNMVIPLCGi----YSQALLTRLLFAVGLASt-LNSFAKWILPEQRPLwwlreiyasnvrspspgvaleshplscettA 75   Drosophila pseud...
AAF51202     1 MFNIIIPLCGi----FSQEILVHLFTAFTLISt-LNSFEKWIYPETRPLwflreqfannvvvkkpavaleshqlscemtG 75   fruit fly

Feature 1         ###                                                                          
AAH76446   110 GSPSGHAMGSAAVGHVMITALlsilaerklpp-------------------------liyrlvqlmlWMFLGLVELLVCM 164  zebrafish
NP_066999  110 GSPSGHAMGASCVWYVMVTAAlshtvcgmdkfs-----------------------itlhrltwsflWSVFWLIQISVCI 166  human
AAH45085   114 GSPSGHAMGSSAVYYVMAHAVisallenktt--------------------------frsrfercalWLFFWSVQVNVCL 167  African clawed frog
AAP92612  1301 GSPSGHAMGTAGVYYVMVTSTlaifrgkkkstygfrickmkqdphtnrkiklggkmhvigmqdetgpNTPTGKLNSAHLW 1380 Norway rat
CAG06568   109 GSPSGHAMVTAAAWWVMVSSLgsflyvrtr-----------------------------svalsavpYLLYVGMLVAVGL 159  Tetraodon nigrov...
P35575     114 GSPSGHAMGTAGVYYVMVTSTlsifqgkikpt-------------------------yrfrclnvilWLGFWAVQLNVCL 168  human
XP_418136  111 TGPVLVLMELSTPCRILWAML----------------------------------------------WTGFWAVQVCVCL 144  chicken
XP_582153   47 FPIWFHLREAVGIKLLWVAVIgdwlnlvf------------------------------kwclnvmlWLGFWVVQLNVCL 96   cattle
AAH21574   109 GSPSGHCMITGAALWPIMTALssqvatrar-----------------------------srwvrvmpSLAYCTFLLAVGL 159  human
EAA12723   113 GNPSGHLMTSTTYLFVIFSVLeeylakyg-------------------------------rfarvslRFVYYSTLFFISI 161  Anopheles gambia...
EAL33224    76 GMPCAHSMSFTVFTLTIWMFLyahsr------------------------------------qrwlaGTVVHGLIFSMWL 119  Drosophila pseud...
AAF51202    76 GLPCAHSMTFTVFVLILASFFfvhcwdrfaa--------------------------lrssfcrcimYLLIIGMVVCMWL 129  fruit fly

Feature 1       #     #   #                                                                    
AAH76446   165 SRVYLAAHFPHQVICGVISGIIVAETFSRVq---WIYSASLKKYFSITLFLLSFa------------------------- 216  zebrafish
NP_066999  167 SRVFIATHFPHQVILGVIGGMLVAEAFEHTp---GIQTASLGTYLKTNLFLFLFa------------------------- 218  human
AAH45085   168 SRVFVAAHFPHQVIAGVFSGMLVAEIFNHVq---CIYKTSFKRYIYATLFLFFFa------------------------- 219  African clawed frog
AAP92612  1381 NDGRLPVATPIPHRSFSHTGIAVAETFSHIr---GIYNASLQRYCLITFFLFGFa------------------------- 1432 Norway rat
CAG06568   160 SRIFILAHFPHQVIAGSVSGLSFVTLRQHIh---IYQSLILGWKFKILIALGFIlgiilsgrvpqgrsllfisialllgt 236  Tetraodon nigrov...
P35575     169 SRIYLAAHFPHQVVAGVLSGIAVTETFSHIh---SIYNASLKKYFLITFFLFSFa------------------------- 220  human
XP_418136  145 SRIFIAAHFPHQVIAGVISGMAVAETFQHIh---SIYHASLRRYLGITFFLFSFa------------------------- 196  chicken
XP_582153   97 SRIYLAAHFPHQVVAGVLSGIAVAETFRHIq---SIYNASLKKYFLITCFLFSFa------------------------- 148  cattle
AAH21574   160 SRIFILAHFPHQVLAGLITGAVLGWLMTPR----VPMERELSFYGLTALALMLGt------------------------- 210  human
EAA12723   162 SRMYFGCHFLHQCIFGILLGILMSKVCLSHrlekYIAKQSGKRRVGFVVLICLAm------------------------- 216  Anopheles gambia...
EAL33224   120 SRLYLATEFLHQCVLGTFIGIQAMDALDQKn--dYLWSRRRRWAVTGVFLLGGLa------------------------- 172  Drosophila pseud...
AAF51202   130 SRLYLATEFLHQCILGSYLGIRSLCTFEGNv--kYLFSRPRRYAVSAVFFLGGLa------------------------- 182  fruit fly

Feature 1                                                                  
AAH76446   217 vGFYVLLKALGVDLLWTLEKAQKWCINPAWVLMDATPFASLLRNMGTLFGLGLGLHLSHY 276  zebrafish
NP_066999  219 vGFYLLLRVLNIDLLWSVPIAKKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMF 278  human
AAH45085   220 lGFFLLLKVFGVDLLWTLEKAKRWCARPEWIHIDTTPFAGLLRNLGVFFGLGLALNTQMY 279  African clawed frog
AAP92612  1433 lGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMY 1492 Norway rat
CAG06568   237 vGLYTGLQWLGLKLSWSILLAKKWCSRPDWIRMETAPFSALIRDCGTLLGLGLAQCWRPC 296  Tetraodon nigroviridis
P35575     221 iGFYLLLKGLGVDLLWTLEKAQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMY 280  human
XP_418136  197 lGFYLLLRMLGVELLWTLEKAQRWCAHPEWVHIDTTPFASLLRNLGILFGLGLALSSHMY 256  chicken
XP_582153  149 iGFYLLLKWLGVDLLWTLEKAKRRCERPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMY 208  cattle
AAH21574   211 sLIYWTLFTLGLDLSWSISLAFKWCERPEWIHVDSRPFASLSRDSGAALGLGIALHSPCY 270  human
EAA12723   217 lSLYWAQKLLGIDPQWAVKMAFKWCEDPFYLKPTTTLVFSAIRLTGSLLALAVVGPIQKA 276  Anopheles gambiae str. PEST
EAL33224   173 aAVYFVKLSLEIDPHWSVREAFKWCPDPSYMRHEASPIFFLVRDLGILMGIALASPLSNL 232  Drosophila pseudoobscura
AAF51202   183 lSVYYVKLELNIDPHWSVREAFKWCPEPTYLRHEVGPIFALVRDLGNLMGLALASPLYKL 242  fruit fly

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