5AFU,6F1T,6F3A,6F38


Conserved Protein Domain Family
ASKHA_NBD_Arp10

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cd10207: ASKHA_NBD_Arp10 
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins
Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.
Statistics
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PSSM-Id: 466813
Aligned: 43 rows
Threshold Bit Score: 249.092
Created: 6-Oct-2006
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
nucleotideoligomer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:5AFU; Sus scrofa dynactin binds ADP, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #### #                                                                     
5AFU_J         5 VVIDLGEAFTKCGFAgeTGPRCIIPSVIKKAgmpkpikvv---------------------------------------- 44  pig
CBY07791      16 VVVEFGSRYTRVGFSgeTGPRAICRTPANLRra----------------------------------------------- 48  Oikopleura dioica
XP_004363931  39 VVLEFGSRLIRVGFAseHCPRHLIPNPPLSHfadptitpasktptttttttpstaasq---------------------- 96  Capsaspora owcz...
EWM27115       6 VVLDLGSAIIKCGFAgeSSPRHLLPSPLDDWsrqaasr------------------------------------------ 43  Nannochloropsis...
XP_013760563  11 IVLDIGCTHVRVGLAgePFPRATLASSLALPdgrvlslavvrp------------------------------------- 53  Thecamonas trah...
CEH18326      75 VVLDIGLSVAKYGFEdeSRPRGLLRTSQYSLwtpdfwkgckd-------------------------------------- 116 Ceraceosorus bo...
KRX00266       4 FIFDIGIAYTKIGQLgkNQPQMILKTPNNLFkklkeidifekpqnlmdslidenymakqlkkqqnlkqpeqeetseqqek 83  Pseudocohnilemb...
OAF69496      17 IVLDIGSSYTKCGFSgtSRPICIIPSAFHSQaankviyien--------------------------------------- 57  Intoshia linei
RAW35940      11 LVLELGARYVRCGVSgeRSPRCVERWQVGDMlqkpl-------------------------------------------- 46  Phytophthora ca...
XP_025600877  65 IVLDLGVRLCRTGFSgeAAPRFSLPTPAAAAalfapdvwsacr------------------------------------- 107 Tilletiopsis wa...
Feature 1                                                                                        
5AFU_J        45 -------------------------------------------------qyninteelYSYLKEFIHILYFRHLLvnprd 75  pig
CBY07791      49 ---------------------------------------------------------sVDEIGEFLLWLYHIHLQispre 71  Oikopleura dioica
XP_004363931  97 --------------------------------qsdavgpadlqllfqrsarrsqtallTGALVRFMQHVYVDLLLlnprd 144 Capsaspora owcz...
EWM27115      44 ---------------------------------------------------gwgseewTQSLGPLLVRLLVHCLHvrpse 72  Nannochloropsis...
XP_013760563  54 -----------------------------------------------thfqrgsdpewREATALWLRSLVGETLQvdpte 86  Thecamonas trah...
CEH18326     117 -----------------------------------------------erarrsreldlLVNVTKLLRVIFYDLLLidprg 149 Ceraceosorus bo...
KRX00266      84 nknedeslndqeknklqdqdqnqeniqqrddslekqnssqsekqnenqqkykqflhtlRLPLQEFLTNIFYYELQikpnq 163 Pseudocohnilemb...
OAF69496      58 -------------------------------------------------iiskyepfyYHLLKEFISVLYLRYLHvksne 88  Intoshia linei
RAW35940      47 -----------------------------------------------------sssewRQYLYPKLHALCFKLLLvnpsr 73  Phytophthora ca...
XP_025600877 108 ----------------------------------------------tpaqrrahelrlEEEATRLLRFLLLERLLidpkg 141 Tilletiopsis wa...
Feature 1                                                                                        
5AFU_J        76 RRVVVIESvlcPSHFRETLTRVLFKyf-evPSVLLApSHLMALLTLGi-------------------------------N 123 pig
CBY07791      72 RRLLVVEEinePREFRERLVEAALKri-alPGLVFLpRPVAAITTTGil-----------------------------sS 121 Oikopleura dioica
XP_004363931 145 RRVIVVEDrdtPEAFRNALAAALFSpqldvPAVSFVqSHDATTLAVAsfapaaaagkatepgtarqptptaasvgggpaA 224 Capsaspora owcz...
EWM27115      73 NKVLICEPlagSTTFREALAYVLFQwl-rvPAIVMApSLEMPLYTAGa-------------------------------E 120 Nannochloropsis...
XP_013760563  87 RRLVVAEDvstPSRFRNALAHVALAel-gmVSLLMHpAGALGLLALRl-------------------------------P 134 Thecamonas trah...
CEH18326     150 RRIVLVENallPDYAARALCKVLFSnl-qvANVALLpAPLISLLAVGr-------------------------------M 197 Ceraceosorus bo...
KRX00266     164 KNIYICENfmmPRPFIEILADILYTqf-evGKVFYFlSNSLPLYLTEq-------------------------------Q 211 Pseudocohnilemb...
OAF69496      89 KKVTIVENmfmSKLLRDALAKIFFTvf-dvPGLNFLpCLLSSFYVLGn-------------------------------Q 136 Intoshia linei
RAW35940      74 RRFVVCEDlllPRVFRETLLNILFDvl-naSAVTLVpSMVAVLYATAn-------------------------------H 121 Phytophthora ca...
XP_025600877 142 RAVLLVTNaltSHAARDTLASVLLLnl-nvRILSFIpHASACTLAAGr-------------------------------R 189 Tilletiopsis wa...
Feature 1               ##                              #                                        
5AFU_J       124 SAMVLDCGYrESLVLPIYEGIPVLn--cWGALPLGGKALHKELETQLleqctvdtgaa---------------------- 179 pig
CBY07791     122 TGIVAQLGWsGVNITGVIHGVPQIw--nQQESTIGGCFLLDEFRKKVdpn------------------------------ 169 Oikopleura dioica
XP_004363931 225 TFLLVDCAHaRTAILPIVHGVPVTa--aYTTLPIGGAAVERQLALQLgksf----------------------------- 273 Capsaspora owcz...
EWM27115     121 TGLVVDVGFrESHVLAVVFGRPLLh--tYAVVGMGALTLLDRARELLesaatakkeg----------------------- 175 Nannochloropsis...
XP_013760563 135 TALVVDVGGaAARTLPVVDSMPLLt--vARESDAAGALIDANIGRLLrqhakirppwapahdlgdlpgdetdaclddpaw 212 Thecamonas trah...
CEH18326     198 TGLVLDVGThHSRLTTVYYGRLLSsrpdILVTRRGSVRLKARLKNLLvyfgryvaatpsta------------------- 258 Ceraceosorus bo...
KRX00266     212 TGIVIESNYyDTQITSVYEGYPQMn--aFTFENCGGYLMNYTIKKELikkfmqitdfneqgik----------------- 272 Pseudocohnilemb...
OAF69496     137 SALILDCAHtHISAIAVYEHVPIIs--sFTFTNNSCRSVNKFILKELrkcnd---------------------------- 186 Intoshia linei
RAW35940     122 TALVVDCGWmETRLLPVFKGVPLPy--lYETVPAGSRNCCKVIQRELnssrdqpm------------------------- 174 Phytophthora ca...
XP_025600877 190 AALVVDIGAsETRFAAVAELGSLHlpyrLMSSTRSRRSVVGRLKLLLlrfgkhvaatpasa------------------- 250 Tilletiopsis wa...
Feature 1                                   #  ##                                                
5AFU_J       180 ----------keqslpsvmgsIPEGVLEDIKVRTCFvsdltrglkiqaak--------fnidgnterpsppPNVDYPLDG 241 pig
CBY07791     170 -------------------ksVTEDFLEDVISRLSFlrsrahllnp----------------petlekqdeKTITIDVNS 214 Oikopleura dioica
XP_004363931 274 -----------------psvqFTSQTIEDIKVRACYvrasrepatt---------------nrtlvyslqgAPESQPLVL 321 Capsaspora owcz...
EWM27115     176 -----------gclsgqrgdrLPLELLQDIVMRACFvvgk----------------------------edfQVDAEPIAY 216 Nannochloropsis...
XP_013760563 213 rewagaalgssggrggdepgeLPRDVVEDFKVKACFvrlgegdk-------------------ldagatppPDTSADVHL 273 Thecamonas trah...
CEH18326     259 --------srkqrtskiraelLDDAFLDDIIAKAIFvaqkpiedveeqrr--------setadvdtsdqarPAAATPTPS 322 Ceraceosorus bo...
KRX00266     273 ------kkyekmqqyqylnkyINFNTLEDLKFRYCKilsrkqkaeffss----------eeniqkmkqqqlNFVINKNIN 336 Pseudocohnilemb...
OAF69496     187 ----------------ledvtISESDLDKIRTKFCIlmdendedd------------------siteteflSSEGNKLSI 232 Intoshia linei
RAW35940     175 -------------dsseivtpATEAMAEDILERACFaqqkd-------------------------plpnvVDAEFHAQD 216 Phytophthora ca...
XP_025600877 251 --------srrsrtgpvkeemLSPAVLDDILDRWLLvpppgstappqapdifdvdallaqqhasfaassraKAMLYPLRA 322 Tilletiopsis wa...
Feature 1                                                                                        
5AFU_J       242 EKILHvlgsirds------------------------------------------------------------------- 254 pig
CBY07791     215 ENVLNvkrsavrd------------------------------------------------------------------- 227 Oikopleura dioica
XP_004363931 322 QESLIgspydvlf------------------------------------------------------------------- 334 Capsaspora owcz...
EWM27115     217 EEKGFkltltpelrt----------------------------------------------------------------- 231 Nannochloropsis...
XP_013760563 274 SHGLEtvydiqgcvrg---------------------------------------------------------------- 289 Thecamonas trah...
CEH18326     323 TFGLTptsgpqasssaldiegraydeskdealmrqlqsryahtskasslilpvpsressdphapvlqnstassasqqqhs 402 Ceraceosorus bo...
KRX00266     337 QKIPIsyydtvfa------------------------------------------------------------------- 349 Pseudocohnilemb...
OAF69496     233 SKIIRkqaf----------------------------------------------------------------------- 241 Intoshia linei
RAW35940     217 NDVLQvpgnlrtda------------------------------------------------------------------ 230 Phytophthora ca...
XP_025600877 323 PPKLEphaersapatlgalvaaaspsl----------------------------------------------------- 349 Tilletiopsis wa...
Feature 1                                                                  ### #                 
5AFU_J       255 ----------------vveilfeqDNEEKSVATLILDSLMq-cPIDTRKQLAeNLVIIGGTSMLPGFLHRLLAEIRYLve 317 pig
CBY07791     228 ----------------tvellfdrRAEDETISTKILDLLLe-sPIDNRRALAaHIILSGGLAKIKGIRRRVLDQIKGQl- 289 Oikopleura dioica
XP_004363931 335 ----------------addpvddgDEHEQSLVSSVLQALLe-sSVDDRAALAaNILLVGGTSGAAGFLKRFAVELNHTvn 397 Capsaspora owcz...
EWM27115     232 --------------tvaeglfaesVDDGESLPIAVLECLRr-cPRDVRRLLAsHVLVSGGVAMLPGFCPRLAEEVQQRar 296 Nannochloropsis...
XP_013760563 290 -------------laaevlfhsnnAAEIVSLPELVLLTLVa-aPMDVRGTLAqNIVVIGGSASLPGLHRRLGFELDALvs 355 Thecamonas trah...
CEH18326     403 qasgvivvpnwireravdvlfepgDDDEKSLPELICDALIn-lPIDMRIPLAkQMLVTGGVATMAGFAHRLKEEVTRLld 481 Ceraceosorus bo...
KRX00266     350 ----------------geilfgnvENEETNIAYSFLSALKkldPLTVKKQVQ-NVIFSGGVTQIKGFISRFREEIIYFld 412 Pseudocohnilemb...
OAF69496     242 --------------------iqllDSSEGSIITLIDKVLQk-vPITFRHIIAnKLYFTGGLVHQDQFVPIVMQKLRKHlq 300 Intoshia linei
RAW35940     231 ---------------veqlilgdeGTEGTSIVDGIVQVLKk-aPLDVRAAMLeNLLLVGGTAMIPGLAQRVAAEVRETlr 294 Phytophthora ca...
XP_025600877 350 ---gtlvlpgwvreraaevlfekgDEDEASLVEAVLELLLh-lPIDLRRPLAsNILVVGGLCSLPDLAHRLRLELEAAle 425 Tilletiopsis wa...
Feature 1                                                                                        
5AFU_J       318 -------------------kPKYKKTLGTKTFRIHtpp------------------------------------------ 336 pig
CBY07791     290 -------------------kEERYKKLQELRFSIVdmp------------------------------------------ 308 Oikopleura dioica
XP_004363931 398 -------------------nTPRFKSLLPLLTPTDtrpafgv-------------------------------------- 420 Capsaspora owcz...
EWM27115     297 -------------------vRVRYQELCPLLLGHQgtsrahealapsahapsippppts--------------------- 336 Nannochloropsis...
XP_013760563 356 -------------------sDGRFRELAPLAGRFRfvps----------------------------------------- 375 Thecamonas trah...
CEH18326     482 nctidqphsvaltvprvgawPGRSEQSARKASRALadkdlnkaqvgaagtddrdtrgkdtterkappreimr-------- 553 Ceraceosorus bo...
KRX00266     413 -------------------nNKEFARIKYIRDHIKftni----------------------------------------- 432 Pseudocohnilemb...
OAF69496     301 l-----------------ngSNLSRHLSYYNTPLGk-------------------------------------------- 319 Intoshia linei
RAW35940     295 -------------------hDNEFASASTAVDRAQlvqa----------------------------------------- 314 Phytophthora ca...
XP_025600877 426 rvaa----------gaseraAGMQQQPALSQTRVGalasreerearrralldvqpqqqgdsseaasaaggdggsramvlp 495 Tilletiopsis wa...
Feature 1                                                #                                       
5AFU_J       337 -------------------------------------akaNCVAWLGGAIFGALQDILg------sRSVSKEYYNQTGr- 372 pig
CBY07791     309 -------------------------------------cqsNCISWLGGAIYASGESTWrtqidlanCALPKEETGELErr 351 Oikopleura dioica
XP_004363931 421 ---------------------------------vdsvfpvNTIAWVGGSLLGSLNANDe-------RFVTRETYQQTKs- 459 Capsaspora owcz...
EWM27115     337 -----------------srasppspsalclvagaallaprNVLAWVGGSIYAVLAETLpad---asPFLFRGSYMTAVst 396 Nannochloropsis...
XP_013760563 376 ------------------------------------phgpDHLAWTGASLVGAMTEYLp------qTSISRDEYLDEPk- 412 Thecamonas trah...
CEH18326     554 ---yapiahlwqhvslmndhmpyihsngqaqggdapafapNVVAWVGASLAGSIRTTSl-------SERTKEAWEEAEaq 623 Ceraceosorus bo...
KRX00266     433 ------------------------------------vypnNLLNWIGASLLGGLQGIEk-------FCVSNKQYQENNyt 469 Pseudocohnilemb...
OAF69496     320 ---------------------------------------pNYHAWLGGSIASSLPSDLyk-----dIEMTKQEYMSVKtv 355 Intoshia linei
RAW35940     315 ------------------------------------yfprNMLAWVGGSIYAATESARv-------SAISSKEYRSSKgt 351 Phytophthora ca...
XP_025600877 496 aasslsskltgdrwaplcsllphlrvlndhtlptciplspVAFAWSGVSLAGALASSAgel--cgtLTLTRDAFLAQRak 573 Tilletiopsis wa...
Feature 1                                                   
5AFU_J       373 ------------------------------------iPDWCSL 379 pig
CBY07791     352 lpsk---------------------------idpsriPDWCGA 367 Oikopleura dioica
XP_004363931 460 ------------------------------------iPNWADV 466 Capsaspora owczarzaki ATCC 30864
EWM27115     397 rgrssqdsgegqg---------grvpvlqeglstaggRDVLSD 430 Nannochloropsis gaditana
XP_013760563 413 ------------------------------------iPDWSVV 419 Thecamonas trahens ATCC 50062
CEH18326     624 ererlnrlganedaagarplfgsgrgsfvgvvggihtGAWGAL 666 Ceraceosorus bombacis
KRX00266     470 ------------------------------------iPDRFGT 476 Pseudocohnilembus persalinus
OAF69496     356 p----------------------------------mrYDWLHS 364 Intoshia linei
RAW35940     352 -----------------------------------svPDWLTV 359 Phytophthora cactorum
XP_025600877 574 eetrpptrpggv-----------grgsfmgvvgglhtGAWGAL 605 Tilletiopsis washingtonensis

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