5V3C


Conserved Protein Domain Family
TGT

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pfam01702: TGT 
Queuine tRNA-ribosyltransferase
This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine. It catalyzes the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues.
Statistics
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PSSM-Id: 460299
Aligned: 513 rows
Threshold Bit Score: 186.534
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5V3C_A        13 Eg---kARTGTIEM------KR-Gv---IRTPAFMPVgTAAT-VKA-L-KPETVR-A--T-G--ADI---ILGNTY-HLM 66  Zymomonas mobilis
3_pfamImport   1 L-----SRVTRLFSr-------------TQTPCYLPPsIAGN-VPH-L-TPGGT--F--L-R--------LLGEVFtDVQ 46 
XP_001778430   9 Sg---hGRVGSLRL------AS-Gl--eFETPSLLMI-TRRG-LP--VvIPPEMLmD--L-HpdSRA---CQFTPM-HFL 65 
ERM99654      11 G-----ARTGVFTV------GSsp--lpIETPSLLLS-TRKG-LP--FfTPPDLLlSlnN-HnnSHL---LQISPL-HFA 68 
XP_002325954  11 SkgnsaARTGVFQL---------GncpqIETPALLLS-TRKG-LPHfI-SPDLL----------PSL---PIPDSS-LLH 64 
EFX83257      11 Ss----ARLGSLTEfa--riPE-Av---FETPLLLLH-TRGAsVPH-L-SYDLL-------Q--------MVSTGH-HML 61 
ETN59481      11 Cs----GRLGLWNGle--rlPNvA----LQTPGLIFH-TKGGsVPH-V-SKEVLQqLssA-PqfLQM---SISNTI-HMQ 72 
B0WAN0        11 Cs----GRLGSLSGvdrlasSAk-----FQTPTLVLH-TKGGsVPH-L-SKEVL--HylT-G--AEP---QLMQ-Y-SLN 68  southern house ...
Q16RF5        11 Cs----GRLGTLNVkn--afSNvS----ISTPALVLHaKGGS-IPF-L-SREVLQyL--TaE--TPImqhSLTNTD-HME 72  yellow fever mo...
XP_009020042   6 CksaskYRLGELED------ELgNv---FKTPACIFY-TGGGqIPY-M-TKDILEdSslLpS--------ILQMSL-NQF 64 
5V3C_A        67 --LRPGAER-------I-------------AKLG-GLHSFMG-------Wd---rP-----ILT-DSG-----GYQvmsl 102 Zymomonas mobilis
3_pfamImport  47 dlTAQVVDF---------------------ADIS-SLVQLAT-------Ht---rPf---rELL-NVA-----DYAlvls 85 
XP_001778430  66 --EDPLAAV-------V-------------AKAG-GVHKLAS-------LtgfamV-----AVArDSL-----GNEiag- 104
ERM99654      69 --GCPSEKT-------I-------------SDIG-GVHELLG-------Lq---dC-----SFI-GVA-----RDSivcl 104
XP_002325954  65 --VSPLHFMegissktI-------------SSIG-GIHKMIG-------LhdfglA-----AVA--RD-----SIQclpe 109
EFX83257      62 --QMPLVTL-------VdhtknvkafgkgiAEFA-GLKEYLN-------Y-----V-----SVQ-DSGtttpeGYH---- 109
ETN59481      73 eaV-QGCQK--------------------------TLGEFVAq-----------nDavsmlVLR-DPS-----EVPvsg- 107
B0WAN0        69 g-TVHMEEA-------V-------------RGCGdGLSGFVAqkesvslL-----------VLR-DPAepcqpGYH---- 111 southern house ...
Q16RF5        73 ------EAV-------R-------------ACDE-GISSFVG-------Hke-siSl---lVLK-DPA-----EQCkps- 107 yellow fever mo...
XP_009020042  65 --VHAKDAI---------------------TSFGqGLSGFTNmkn-qpiYcstrdP-----SLT-LTS-----GYSk--- 106
5V3C_A       103 s-------sltkqSEEGVTFKSHLdGSrHMLSPERSIEIQHLLGSDIVMA-FD-ECTPYPATPSRAASSMERSMRWAKRS 173 Zymomonas mobilis
3_pfamImport  86 ardyisesnppssRATGFMIETS--GGrRAVSIEEFMQATELLQPQLVVPlAD-E-ISSEKGRNRHRAAVQTSLEWLDAC 161
XP_001778430 105 ----------eeaSNLGASFETSs-GR-RIVGLEKYMEVVNACKPDLWVSlPD-E-VPHWVPEKRNRESVDHTSQWLDHC 170
ERM99654     105 p-------hsegtNKFGASFETPs-GR-LLVKPRDYMEIISSLKPNLWTSlAD-E-VPSWVTEKRNRSSVDRTIRWLDDC 173
XP_002325954 110 ---------ssatNKLGASFETPC-GR-LLIKPAEYMGIISSLRPNLWATlAD-E-VPAWVSKKRNKNSVDRTVKWLDEC 176
EFX83257     110 -------------EKNSISLWTR--GGrKLIDPQTYISCIEALKPDMFQAiVD-GDTTQSSSAKRVRKSVDVTVKFAGIC 173
ETN59481     108 -----------vpERDAVPIYTRC-GR-RTVKVDAYMRLVETFQPDLYVPlYD-GDTELGCSKKREQKSVERTETLVQEC 173
B0WAN0       112 -------------EKDVVPVFGRs-GR-KNFTAESYMSLVEAFRPDVYVPlFDgD-TDGGSSKKREQRSQERTETFVEQC 175 southern house ...
Q16RF5       108 -----------fhEKDFVPIFSRS-GR-KNFTSERYMQLVEAFKPTVFVPlFD-GDTDLESSKKRLQKSLDRTEKFVEQC 173 yellow fever mo...
XP_009020042 107 -------------GNQGLSVWSL--GGkYVFEAEDYVDYVESLRPSIVEIlCE-DYSDVSATNKKIDKCTEKSFNFLKRC 170
5V3C_A       174 R----DAFDSrkeqAENAA-LFGIQQGSVFENLRQQSADALA--EIg--Fd----GYAVGGl--------aVGE--GQ-- 228 Zymomonas mobilis
3_pfamImport 162 Q-----ALN------SSGTpMCGVVVGGNDQTLRQMSAAETC--KRd--Iq----AVLLSG----------LGSctDR-- 210
XP_001778430 171 LslqhAEH---------GNrCLGVVVGAGSLEERARSAEQAA--TRn--Va----GFSLAGf--------gLGE------ 219
ERM99654     174 I-----ALDP-----AGGSsILGAIVGGSSIDERRRSAHEAA--ARn--Va----GYWIGGf--------gLGE--SL-- 223
XP_002325954 177 ValspA-----------SGvAFGAIVGGSDVEERRRCAQEVV--KRn--Vs----GYWIGGf--------gFGE--ST-- 225
EFX83257     174 A----DLKEKs--dVLKDTpMLACITGGYNTKERLRCINELK--GFg--Aa----GYVIEGfh-------tNGEs-AT-- 229
ETN59481     174 L----EWHRKseklSGHHTsLIAPVVGGYSEKLREKAIEWLRqtEHd--Fa----GYLIEGl--------hTYD--PSlv 233
B0WAN0       176 L----EVHRKs--eKLKGAsVLGPIVGGYNKKLREKSVQFVErlKDd--Fa----GYFIAGlhsygssaseVKE------ 237 southern house ...
Q16RF5       174 V----EAHRKs--aNLKESnLIGPVVGGYNLKLRSASVKFL---EQ---FkndleGYMIAGlhsnglsateLKE------ 235 yellow fever mo...
XP_009020042 171 I----ERFNKs--dVLKGSrLIAPLIGGYNRQKRADYAARVS--QFdqvF-----GYSLSGfh-------nFGT------ 224
5V3C_A       229 -----DEM---FRVl----DFSVPML-PDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRS-GRNGQAFT-------- 286 Zymomonas mobilis
3_pfamImport 211 -----AER---LQLi----DAVVDELsPASLPRVVTGIGHPLDVLDAVNRGIDAFVSPYPASV-TKAGSALVfwtsdded 277
XP_001778430 220 -----DVAqrgFHLe-----VAIAKL-PNDKLRHVCGLGSPEEVLQAVGAGIDLLDSTYPYML-TKECLAMTfplkmevp 287
ERM99654     224 -----DER---PSLl----NAVTDNL-PVEKPRQICGLGLPEEVLQGVAAGVDLFDSTYIYHL-TMGGFALTfaldteen 289
XP_002325954 226 -----DER---PALl----SAVTDIL-PKDGPRLISGLGLPEEVLQGVAAGIDLFDSSYIYHL-TIGGFALT-------- 283
EFX83257     230 -----NLL---WEDvepvlTETLGSL-PENLPRAFHGPITPIVLLKLVSKGIDIFDATFPWLVaERGGALVF-------- 292
ETN59481     234 sritsETI---LPIv----TPVCKAL-PEERVRLCFGAYDPTVVLELVSAGVDVFDTSYVYLKaAQQHRALIfsf----- 300
B0WAN0       238 -----APL---LDIv----SSVCQQL-PLEKPKFLFGAFTPQLVLELVVRGVDIFDTSYPYLK-TQQNRALN-------- 295 southern house ...
Q16RF5       236 -----SNL---VEVv----SHTCQSL-PTDKVRFMFGAFSPRIILKLVAQGIDVFDTSFAYLK-TQQNRALTfsfdvndk 301 yellow fever mo...
XP_009020042 225 -----ESFkmdFDYnkdfiDVVFEKV-PEDKLRILPGSFTPLQIIQAVRCHLDVFDSSYAYWA-CESKAALTlnleve-- 295
5V3C_A       287 -------------W--D-------------G--------------------------------------------PI-NI 293 Zymomonas mobilis
3_pfamImport 278 gisasernaererS--G-------------G--------------------------------------------VL-HL 297
XP_001778430 288 lr-nadrdmqptpD--H-------------Gvasg------------------------------------fslaKV-NL 314
ERM99654     290 -----yahssvlgY--A-------------Gdd----------------------------------------htKI-NL 308
XP_002325954 284 -------------FplDnktyasdlkltgmGsd----------------------------------------qtKI-NL 309
EFX83257     293 -------------P--N-------------SlskenapvtetlpsvkapavvatdqkvakladdnsndesvdrvyEI-NL 343
ETN59481     301 -----------nvS--ApeaeeqqessqhtT--------------------------------------------EL-DT 322
B0WAN0       296 ----------------FsfdtsdsnvvarkN--------------------------------------------EL-DL 314 southern house ...
Q16RF5       302 --------------------------------------------------------------------nvdsretEL-DI 312 yellow fever mo...
XP_009020042 296 --------ghdlaT--S-------------Gddl---------------------------------------dsNIvFL 313
5V3C_A       294 RNARFSEDLKPLDSECHCAVC-QKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRArY 372 Zymomonas mobilis
3_pfamImport 298 RESRYATDFGPLVAGCDCFACqK-YTRAYIHHLLNVREMLGDILLYLHNLQHYYRFFREIRTAIDTDSFAAFHAEFASkF 376
XP_001778430 315 RSATYGIDETPLVTGCKCYTCkR-HTKVYINQLLNSNETLAQTLLEIHNTYHYLEFFKAIRESIKADKFHEFRTWFTSqR 393
ERM99654     309 RATIYRKDLSPIIDNCDCYTC-QNHTRAYINHLLNVHEMLAQILLEIHNTHHYLGFFRMIREAIKRDEFESFQKSFLEgR 387
XP_002325954 310 KATVYRKDATPIVESCSCYTC-QNHTKAYINHLLNVHEMLAQILLEIHNTHHYLGFFRSIREAIKEGRFEQFREMFVEkR 388
EFX83257     344 KDKIYFSDTRPLLEGCSCYSC-RKYSRSYVHHLTATGELQGPILIMMHNLHHYINFFKSIQQAIKDNELQALQSKLDLfV 422
ETN59481     323 TDTRWAEDFSPLLAGCSCYTC-QKHSKAYVHHLYNTREMLGPILLMIHNLHHYMEFFKTIRHHVAQDTLPQLREHLSLqR 401
B0WAN0       315 TDACWAEDFTGFVDGCQCLACtK-HTKAYTHHLYNTREMLAPILLMIHNLHHYFEFFKAIRRHVAQDTVGELIA-HINkH 392 southern house ...
Q16RF5       313 RDPRWAEEFTGFVESCSCLACtK-HTKAYAHHLYNTREMLAPIILMMHNLHHYFEFFKAIRKHVSEDTLDQLVEHLQKqK 391 yellow fever mo...
XP_009020042 314 TEARYTHDDRPILSRCTCYTC-KNHARSYIRHLLLTKELLGSILLSIHNHHHLNEFFICMRLAMESDGLDHFEAKIKEkS 392
5V3C_A       373 FA 374 Zymomonas mobilis
3_pfamImport 377 EE 378
XP_001778430 394 QE 395
ERM99654     388 RS 389
XP_002325954 389 RI 390
EFX83257     423 SS 424
ETN59481     402 TL 403
B0WAN0       393 VV 394 southern house mosquito
Q16RF5       392 DV 393 yellow fever mosquito
XP_009020042 393 LP 394
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