6S2E


Conserved Protein Domain Family
Dcc1

?
pfam09724: Dcc1 
Sister chromatid cohesion protein Dcc1
Sister chromatid cohesion protein Dcc1 is a component of the Ctf18-RFC complex. This complex is required for the efficient establishment of chromosome cohesion during S-phase and for loading the replication clamp Pol30/PCNA, which functions in DNA replication and repair. Ctf18-RFC loads PCNA onto DNA in an ATP-dependent manner. It may also have PCNA-unloading activity.
Statistics
?
PSSM-Id: 462857
Aligned: 107 rows
Threshold Bit Score: 158.567
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6S2E_B        15 YKLIQLTPELLDIIqdpvQNHQLRFKSldKDKSEVVLCSHDKTWVLKQRKHSNTVLLmrefVPEQPITFdetllf--gls 92  Saccharomyces c...
XP_004229694  40 LMLLELDEKLLPDI----LNQRVTIRG--QPDEDAVLCSQTKTYAIKFVGTSNSLFLippsNLSIALGAspnsse---kd 110
ANM62315      33 LLLLEADDKLVSDI----FHQRVTLRG--LPDEDAVLCTKSKTYAIKFVGNSNSMFLippsifpg-----------daqv 95 
KRH56212      38 LLFLELDEKLLPDV----LNERVVLRG--QPDEDAVLCTQSKTYAMKFVGTSNSVLLvppaNHSEYYENqlknds---ns 108
XP_019081347  38 LILLEIDDKLLPDV----LHQRVTLRG--QPNEDAVLCTQSKTYSIKFVGNSNSVFLippvDQSALHEHpqysde---kd 108
XP_002298532  36 LMLLEIDEKLLPDI----LHERVALRG--QLDEDSVLCTQSKTYAIKFVGNSNSPFLippsGQFALCENsqdfd------ 103
EEF35904      37 LILLELDHNLLPDV----LHQRVTLRG--QPDEDAVLCTQSKTYSIKFVGTSNSSFLipqsGQFSMYDYpedcda---rv 107
XP_009405569  39 FLLLEADEALLPDI----LHNRVTIRG--QTDEEAVLCTPLATYAMKFVGTSNSVFLippgEPIPPCMEdtcndsksnts 112
ERN09144      41 FLLLELDPTLLPYF----YNNQVTVRG--DPDEEAVLCTPSSTYALKFVSTSNSVFLipppSFENPMQKp---------- 104
EFJ40141      25 LRLLEVDEKLLQEI----MEKGVVIKG--GEEEEAVLVTSCRTYSMKLVETTNLQLLvgpeEEEEEEFFpppqfr---sa 95 
6S2E_B        93 kpyMDVVGFAKTESEF-ETRETHGEL-NLNSV------PIYNGELDFSDKIM---KRsStk------------------- 142 Saccharomyces c...
XP_004229694 111 hdnAMVASVIKVVPGSmELVEVAPRLdKLKLLls---eNPYSFDEVSQM-------NtElthk----------------- 163
ANM62315      96 sdtNNNVSVLKIAPGNmELVEASPRLdKLKQIll---aNPFGAGEVEAMMDVdndDLdHsgkk----------------- 155
KRH56212     109 deeKVVAPVLKVVSGNmELIETAPRLdKLKSLls---eKPYKLEE-DDMg-----NLeEnqes----------------- 162
XP_019081347 109 ddqRVVASVIKVAPGNmELVEVAPRLdKLKLLll---eNPFTSEEVSEKe-----ELeGmeeq----------------- 163
XP_002298532 104 geindFAPVIKVAPGNmELVEVAPKLdRLKLLls---eNPYSYEDVLEMd-----FMeDvekn----------------- 158
EEF35904     108 harQLFAPIIKLAPGNmELTEVSPRLdKLRLLls---eNPYKSDGVLDMe-----DL-Dtgkd----------------- 161
XP_009405569 113 aahEVVPSVIKVASSNmELVLVAPHLdKLKSLln---eRPYKLDE----------DVeTdfqh----------------- 162
ERN09144     105 ----LSSPVIELSPGHmELLCVAPQLdKLKSLlstvtyNPNITDD-------------Egqee----------------- 150
EFJ40141      96 arlGGPVAVNATSTSHiELVEVAPRLdPIRDLiw---aHPYGVEDEQPAEGAgaeTDtEmaaagiadldtyieggrrstg 172
6S2E_B       143 --------------------viGTLEELLENSPCSALEGISKWHKIGGSVKDGVLCILSQDFLFKALHVLLMSAMAESLD 202 Saccharomyces c...
XP_004229694 164 ------------------nkglYSWSDLVEKVQASDEELCTGLRALAAVEIDGFWRSLDENFVDAILNMLLHNAVLNDWL 225
ANM62315     156 ------------------dlalYTWSDLVNTVQASDEELRNGLQSLSAIEIDGFWRVIDENYLDVILRMLLHNCVLKDWS 217
KRH56212     163 ------------------riglYNWNDLVDNIQASDEELLSGLQALSALEIYGYWRLVDGSYMDMILGMILKNAVLNDWS 224
XP_019081347 164 ------------------ktnlFKWNDLIDRVQASDDELRSGLRALSAVEIDGYWRIVDEKYMGTILNMLLHNSVLNDWS 225
XP_002298532 159 ------------------karlYNWDDLVERVQASDEELRNGLCALSAVEIDGFWRIVDEKYMDMILRMLLHNSILNDWS 220
EEF35904     162 ------------------ktglYTWDDLVGMVQASNNELRSGLQALSAVEIDGYWRIVDEKYMDTILRMLLHNSILNDWS 223
XP_009405569 163 ------------------nrglYRWQDLLEQIQASEQELRDGLKALSAAEIDGFWRIIDEKTMDEILNMVLNNSILHGWP 224
ERN09144     151 ------------------asclFTWSDLISKVQASDQELKDRLNSLSAIEINGKWRILDQGFMSDTLELLIRNATIHGWP 212
EFJ40141     173 aagaaagrggggggggggvkggYTFGELLERIQASPEELRNALAAEGALQLAGRWRAVDPNYLGSLLELVLLTAQQEGMP 252
6S2E_B       203 LqhLNV--EDTHHAVgkdIedefnpYTREIIETVLNKFAVqeqeae-----------nntwrLRIPFIAQWYGIQALRKY 269 Saccharomyces c...
XP_004229694 226 L--SALneDEVLPVLeadG------FPREIVKHCLGVYGSkvddeir---------ggctwrLEERPVCVHFARVILRG- 287
ANM62315     218 F--DDLdeDEVVNALvadE------FPSQLASHCLRVFGSkvnet-------------dkwkLEPRLVCLHFARQILRE- 275
KRH56212     225 L--NALneDEVVSTLesdG------FPGVLARHCLNVYGNrvnecm----------psfvwkLDEKRVCIHFARDILKG- 285
XP_019081347 226 L--DALgeDEVVGVLesdG------FPRTLGLHCLQVYGSkvdegv----------gscvwkLDERRLCIHFAREILKD- 286
XP_002298532 221 L--DALneDDVVSVLvsdG------FPDKLACHCLHVYGSkvdgdvg---------rscvwrLDESRVCVHFARQILST- 282
EEF35904     224 L--DFLneDEVTNLLasdG------FPHKLAHHCLNVYGTkvnggvg---------tgyvwkLDERRVCVHFARETLRA- 285
XP_009405569 225 L--NALeeDEVVSILeadG------YPRNITLHCLETFGNmvessg-----------csfwsLDEKKVCLRFALQALGG- 284
ERN09144     213 L--GALreDLVLPVLeadG------VSLEFGCHCLKAFGRekdv--------------gvwaLCERAVCVNYARKILGKV 270
EFJ40141     253 V--GCLreDVLVESLrqdG------YHPDVVRHCLSVYGKsavgaesdggpggargnprvwcLDETKVCVHFASRVMGG- 323
6S2E_B       270 vsgISMPIDEFLIKWKSLFPPFFP-CdidIDMLRGYHFKptd-------------------------------ktVQYIA 317 Saccharomyces c...
XP_004229694 288 ---EKMKLERFMEEWRKKVPEGMNaS---FDVLEGEVLTekig----------------------------ietrIYAFS 333
ANM62315     276 ---EKMRLESFMEEWKKKIPDGMEeR---FEMLEGEVLTekig----------------------------ietrVYTFS 321
KRH56212     286 ---GKRKLESFMDEWRQKIPDGMQpT---FDLVEGEVLTekig----------------------------vetwVHAFS 331
XP_019081347 287 ---GKRKMESFMEEWIQKIPDGMQaS---FDMLEGEVLTekfg----------------------------vetwVRAFS 332
XP_002298532 283 ---GKKKMETFMAEWLQRIPGRMQaS---FNMLEGEVLTeklg----------------------------vetwVYSFS 328
EEF35904     286 ---GKKKMEDFMGEWLKKIPDGMEaK---FDMLEGEVLTeklg----------------------------vetwVRPFS 331
XP_009405569 285 ---GKMKLEIFLQKWRHCVPSGMHaD---LKMLEGEVLYeklg----------------------------fetwIRSFR 330
ERN09144     271 ---GKMKSENFLMKLQRRVPEGFAvG---MEMLEGEVLAervg----------------------------aevwVRAFS 316
EFJ40141     324 ---RTMLLNDFIEAWKRAVPYGLTpS---LDMLRSEALIdvygnpanppvewghaqtrtdtqthtyeegsgadarISPFP 397
6S2E_B       318 KSTLPMDPKERFKVLFRLQSQWDLEDIKPLI 348 Saccharomyces cerevisiae S288C
XP_004229694 334 VSSLSSVPAERFSKLFQEKPKWEWKELQPFV 364
ANM62315     322 VRSLPSTPEERFSVLFKHRSKWEWKDLEPYL 352
KRH56212     332 VASLPSTPAERFSILFRERPKWEWKDLQPYI 362
XP_019081347 333 VSSLPSNPAARFSMLFQERPKWEWKDLQPYI 363
XP_002298532 329 VSSLPLTPAERFNMLFRERSKWEWKDLQPYI 359
EEF35904     332 ISSLPSTPAERFSMLFRERSKWEWKDLHPYI 362
XP_009405569 331 VSALPSTPAERFAALFIERPRWNWKDLEPYI 361
ERN09144     317 VSSLPSDPAERFSILFKERQRWESQDLEPYI 347
EFJ40141     398 ASSLPREPGERFAALFRVRPRWEWTHMEPYL 428
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap