Conserved Protein Domain Family
PIG-H

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pfam10181: PIG-H 
GPI-GlcNAc transferase complex, PIG-H component
PIG-H is a family of conserved proteins that complexes with three other proteins to form the GPI-GnT (glycosylphosphatidylinositol anchor biosynthesis transferase) complex. It appears to be a peripheral membrane protein facing the cytoplasm involved in the first step in GPI anchor formation.
Statistics
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PSSM-Id: 462983
Aligned: 92 rows
Threshold Bit Score: 55.1517
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESW97698     131 SLIIIPNLGVQSESYrvrksgsalvllllsrvlgkselsrhvPAAKTLNRQFFPMEDVHDLAIVEGF-KNFQVIFYLALM 209
CCJ28904       9 SLLVLHNIGLQITLHyfll---------------------------psrTRFIPLSDILDVVIHEGF-IGLEVRYYLALI 60 
Q6C439       121 SLFVVHGIGLQVYSSggyy--------------------------fmgqTTFLNLDSIIDLVIHEGF-KGLEVIFFMTIL 173 Yarrowia lipoly...
EMG48997      96 SIIVMKGIGVQLQSKkl-----------------------wkFQ---SSDSFIPIDNIIDLVIHEGFhDYGQVIFYLCIL 149
EGW34479     101 tMIVMKGIGVQLVTKkk-----------------------wrFQ--NSSQSFIPIKDMIDLVIHEGFhKYGQVIFYLCVL 155
XP_001527666  93 SLIVMRGIGAQLISKrl-----------------------waFQ---NSGKFLPLNSMIDLVIHEGFhDYGQVIFYLCFL 146
ABN68528     101 SITVMKGLGVQLSSRks-----------------------wkFQ--YRSECFIPVSNTIDLVIHEGFhGYGQVIFYLCIL 155
CCE41747      94 TLTIMKGIGAQLESRkm-----------------------lpFQ---SRTIFIPINNVIDLVIHEGFhNYGQVIFYLCFL 147
Q4CX60       152 eVMVIRGLGMQITNYn--------------------------VFGWICSQRFIELKLIRSLVIHDAF-FRYQAIFFLSAT 204 Trypanosoma cruzi
Q57U98       245 eVTAIRGLGLQLNSYn--------------------------ALGRLCFQRFVDIRLIRSLVIHDAF-FRTQVLFFLSAT 297 Trypanosoma brucei
ESW97698     210 VGDGQqd---dQlqIVVIFP 226
CCJ28904      61 IRNED------T--LQVIFE 72 
Q6C439       174 VKDKD------R--TVVIFP 185 Yarrowia lipolytica
EMG48997     150 TKANNd-----EnsITVLFP 164
EGW34479     156 TRSNDqsgnddSniIKVIFP 175
XP_001527666 147 TKSNTemptkkEdaIKVVFK 166
ABN68528     156 TKSSAvgktnnDniIKVAFP 175
CCE41747     148 TKNFQverpgkDsvIQVVFg 167
Q4CX60       205 IEN--------DatRLVLFE 216 Trypanosoma cruzi
Q57U98       298 VEN--------EasRLVLFE 309 Trypanosoma brucei
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