Conserved Protein Domain Family
GT29_ST8SIA4
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cd23988: GT29_ST8SIA4 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4
ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467716
Aligned: 5 rows
Threshold Bit Score: 593.469
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              ###       
Q92187        76 SLVLEIRKNILRFldaerdvsvvkssfkPGDVIHYVLDRrrTLNISHDlhSLLPEVSPMknrrfKTCAVVGNSGIlldse 155 human
XP_018119959  76 SLALEIRKDILRFldaerdvsvvkssfkPGDVIHYVLDRrrTLNISQNlhSLLPEVSPMksrrfRTCAVVGNSGIllssg 155 African clawed ...
XP_007891306  74 SLVIKIRKDILRFldaerdisvvksslkPGDIIHYVLDRrrTLNISRNlhSLLPEVSPMknkrfNACAVVGNSGIllgsg 153 elephant shark
AAH98613      71 TLVSIIRKDILRFldaerdvsviksnfkPGDTIRYVLDRrrTFSVSQTlhSLLPEVSPLknktfKTCAVVGNSGIllksg 150 zebrafish
NP_989614     76 TLVLEIRKSILRFldaerdvsvvkssfkPGDVIHYVLDRrrTLNISQDlhSLLPEVSPMknrrfKTCAVVGNSGIlldsg 155 chicken

Feature 1                     ##                    #                                            
Q92187       156 CGKEIDShNFVIRCNlAPVVEfaaDVGtKSDFITMNPsvvqrafggfrnesDREKFVHRLSmlndSVLWIPAfmvkGGEK 235 human
XP_018119959 156 CGKEIDShDFVIRCNlAPVVEfaaDVGtKSDFITMNPsvvqrafggfrnesDREKFVHRLSmlndSVLWIPAfmvkGGEK 235 African clawed ...
XP_007891306 154 CGKEIDShEFVIRCNlAPLVEytdDVGsKSDFVTMNPsvvqrafgslqnetDRENFVRRLAvlndSVLWIPAfmvkGGER 233 elephant shark
AAH98613     151 CGKEIDNhSFVIRCNlAPLEGfadDVGlRSDFTTMNPsviqrvygglreetQQENLIQRLRqlndSVLWIPAfmvkGGMK 230 zebrafish
NP_989614    156 CGKEIDThDFVIRCNlAPVVEfaaDVGnKSDFITMNPsvvqrafggfrnesDREKFGHRLSmlndSVLWIPAfmvkGGEK 235 chicken

Feature 1                                                   ###                 ##            ###
Q92187       236 HVEWVNALILknklkVRTAYPslRLIHAVRGYWltnkvpikrpSTGLLMYTLATRfCDEIHLYGFWPFpkdlngkaVKYH 315 human
XP_018119959 236 HVEWVNALILknqlkVRTAYPslRLIHAVRGYWltnkvqikrpSTGLLMYTLATRfCDEIHLYGFWPFpkdvhgnqVKYH 315 African clawed ...
XP_007891306 234 HVEWVNELILknklsIQTAYPslRLIHAVRGYWltnkvyikrpSTGLLMYTLATRfCDEIHLYGFWPFpkdangtpVKYH 313 elephant shark
AAH98613     231 HVDTVNELILkhklkVRTAYPslRLIHAVRGFWltnkinikrpTTGLLMYTMATRfCDEIYLYGFWPFpkdasgnpVQYH 310 zebrafish
NP_989614    236 HLEWVNALILknklkVRTAYPslRLIHAVRGYWltnkvhikrpSTGLLMYTLATRfCDEIHLYGFWPFpkdlhgkpVKYH 315 chicken

Feature 1                       #                      
Q92187       316 YYDDLkyryfsnaspHRMPLEFKTLNVLHnrGALKLTT 353 human
XP_018119959 316 YYDELkykyfsnagpHRMPLEFKTLNLLHnkGALKLTT 353 African clawed frog
XP_007891306 314 YYDNLkyryfsnagpHRMPLEFKTLKSLHdrGALKLTT 351 elephant shark
AAH98613     311 YFDGLkyryfsnagpHRMPLEFQTLQRLHskGALKLTT 348 zebrafish
NP_989614    316 YYDDLkyryfsnaspHRMPLEFKTLYVLHnrGALKLTT 353 chicken

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