2EG9


Conserved Protein Domain Family
Rib_hydrolayse

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pfam02267: Rib_hydrolayse 
ADP-ribosyl cyclase
ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.
Statistics
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PSSM-Id: 460517
Aligned: 27 rows
Threshold Bit Score: 286.098
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EG9_B        24 TKHFSDIFLGRCLIYTQIL----------RPEMRd-qNCQEILSTFKGAFVSKNPCDITREDYAPLVKLVTQTIPCDKTL 92  house mouse
EDV29266      24 THNIKEIFIGRCYGYIALQ----------NFTLRpgvTCPSLWQEFSRVFVNREPCEVDPTQYSRFLIESSSPVPPNKAL 93 
OCA47921      55 TKNLKDIVLGRCYNYIT-M----------NPNIWl-rNCDAIWERLTDAVYKKNPCNITEEDFKPLAALASQTIPCNKSL 122
XP_004347950  27 TAHLAEIFVGRCFDKSTVA------------------DCNAWWAAFNQVVADVDPLSVTAASFDPYFAIANFSTPVDKAM 88 
XP_011663015  28 TSNITDILTGRCEEYRKCLlgepclpfyrNV------KCRAAVESFFKGIRNMDPCATPDNAYDEFLNMVPPTTVRGTTM 101
EDV29267      24 TARIQEIFIGRCSEYQAVN------------KLQrqvDCIHVWNQFSRVFAFKEPCAVNASEYDNFIKEVSS-------V 84 
2_pfamImport   1 TPNIKHIVVGRCYNYITLV----------NPSLRi--DCEEIWRRFEESVVFRSSFNATV-DYSQMFDAIPQTWPCNTCL 67 
XP_015200534  51 GGSLKYVFITRCKEYLETH----------DEvrv-giDCNEVWDAFQSSFVAKDPCKISVEAYDGLMNTAKQKVPCNEMV 119
XP_003978724  32 QQTFKETFIARCHLAIKGQ----------YKg----sDCETIWSTFEQAYVGRDPCKIPTDAYNPLFQVAPITMTCGKAM 97 
3_pfamImport   1 T--FKETFVARCEDFNGT-------------------DCEKIWGLFEEAYVGRDPCKVPVAAYGPLIAAAPFPPKCNQRI 59 
2EG9_B        93 FWSKS--KHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGD-PSTS---DMNYVSCPHWsEN-CPNN---PITMFWKVIS 162 house mouse
EDV29266      94 FWSGV--YDFVSSYVQAVDDVLVISQTFTGFLLDKLTWCGRfKSTPqseGINYLYCNDS-QG-CSHR---NMLSFWALAS 166
OCA47921     123 LWSKT--NSLVHRYTKASQDFLTLEDTFLGSMFDGLMFCGK-SYSS---EMNYDSCPAW-DE-CDHN---AISAFWKTAS 191
XP_004347950  89 FWSGS--QYYVHQLSDAGLRYFTMEDTVGGFVQNGLHWCGS---SS---GYNYTSCPPGfRNtTTDTwygAELAFWQHAS 160
XP_011663015 102 FWSGVmgNNIPQDVAQVTPEFSVLEETFPGYMAGNLSWCGAtDGDGtglGLNFTVCPTWtSEtCPNN---TKAAFWARAS 178
EDV29267      85 FWSGT--YSFAHLYIRAVKNLETLENTFPGYLVNSLSWCGQ-LALP---GINYNDCHDP-QH-CNNK---NSGIFWSKMS 153
2_pfamImport  68 FWSKT--RNLMHSYAAVERHFWTLEDTLVGFMFNDLVWCGQ-EKHS---GFGFSSCPPW-AA-STHH---PVYSLWRHAS 136
XP_015200534 120 FWSKT--KQMAHKFTQAKKCFMTLEDTLLGFIMDGLTWCGS-QDGN---DTYTSGCPNW-NT-CEQN---PVRSFWSRAS 188
XP_003978724  98 FWSKT--KDVVHAYNENTKCFVTMEDTLLGSVLDNLIWCGK-EGSN---KTFTSGCPDW-NA-CKDN---PVRSFWTQGS 166
3_pfamImport  60 FWSKT--KAVVHDFTKKRKCFETVEDTLLGSVLDGQTWCGK-EGSN---ETFATGCPGW-TD-CETS---AVRSFWNGAS 128
2EG9_B       163 QKFAEDACGVVQVMLDGSLRE-PFYKDSTFGSVEVFSLDPNKVHKLQAWVMHDIEG--AS---SNACSSSSLNELKMIVQ 236 house mouse
EDV29266     167 REFAKSASGLVRVLLTSDNKTpAFNNQSIFGSIELPNLSPQKVSKVEIMVMHGLNSkpNQ---IDRCGIGSIKELQNILT 243
OCA47921     192 ATFAKASCGVVNVMLNGSADGgVARKESILRTVEVPSMNVNAVSEVRLWIMDNLEG--PD---KNSCNTESVLELKAYIE 266
XP_004347950 161 TTFARQATGRVSVLLGSPYGGsAYRNSSFFALYELPNMNTSLVTAIDVYVITNG---------TERCGSGSLVALVQDIK 231
XP_011663015 179 KMLATQAVGDVYVVLNAQRAGgAFNNGSIFATIEAPNLNQDVVTNVAIYLIPDFTLpiPNemyRETCTNGSVLYLQNFLM 258
EDV29267     154 TWFAQGSSGTVRVLLNSSRIP-AFAPYSFFARYELPNLSPSKVNKIEIIVVHDLDMkvNQ---SERCGAGSIKTLQDLIQ 229
2_pfamImport 137 QNFAEMACGNITVLLNGSISN-AFNRESMFGSVELDGLDPCRVDYVNIKVVTNLEG--PF---TESCSKGSIADLIQVLR 210
XP_015200534 189 AHFAESACGNVTAMLNGSIDK-PFSAKSIFGSVEIKKFNPMKINYVNVVLI--GRE--NY---PMSCKNDSLQELEKTLI 260
XP_003978724 167 TKFAEAACGDATVMLNGNIAT-PFDNSSVFGSVEVPKLNSAKVRKLTVVLV--TAT--TP---VSDCSNESLNELRQKLD 238
3_pfamImport 129 AAFADAACGDVTVMLNGAVAT-PFYNKSVFATIEVPRFRSPKVRSLKVVLVTQENS-------LTSCENESLKDLQRKLD 200
2EG9_B       237 KR-NMIFACVDNYRPARF 253 house mouse
EDV29266     244 SH-NFTWSCQDNPKSVLH 260
OCA47921     267 QH-NLAFSCVDNYKPVQL 283
XP_004347950 232 HHlGLTPSCYDNPDMVRF 249
XP_011663015 259 NM-NFNVTCEENPKEIMW 275
EDV29267     230 QR-NIAWSCSDNPSSVQD 246
2_pfamImport 211 SR-GFRWTCTHNDETLMI 227
XP_015200534 261 P--KFKYTCTTV-LLSTI 275
XP_003978724 239 S--KIGYECKEV-SETRI 253
3_pfamImport 201 G--GITYSCKAV-PEAQI 215
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