4IJ5,6M1X


Conserved Protein Domain Family
His_Phos_1

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pfam00300: His_Phos_1 
Histidine phosphatase superfamily (branch 1)
The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.
Statistics
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PSSM-Id: 459751
Aligned: 330 rows
Threshold Bit Score: 78.7903
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4IJ5_A              4 LILVRHAESEWnp---vgRYQ----GLLDPDLSERGKKQAKLLAQELSREHLDVI-----YSSPLKRTYLTALEIAEAKN 71  Hydrogenob...
jgi:Cyan7822_4494  32 VWIARHGNRLDfvnpewfNTAi---RRYDPPLSEDGIIQAQQLGQRLKSENIAHI-----FASPFLRTIQTANQVAEALD 103
tigr:GBAA_5203      4 IIVIRHCSATG--------------QERDAELTTDGKKQANTLATFLLEHHPQIDh---iISSPFVRAIDSIRPYARQAN 66 
WP_015736428        4 IYFVRHAESPF-------IEG----KERSRGLSAQGSLAAERVKEMLRDEGIDAI-----LSSPYQRAKDTVQPLADALG 67  Paenibacil...
Q8NT72              6 VHLVRHGEVHN-------PEKilygRMPGYRLSSRGRSQAARTAASFEGHDVTYI-----AASPLQRVQETSEPFIKVTG 73  Corynebact...
WP_012085042        8 VHLVRHGEVFN-------PDRvlygRLPGFRLSERGQAMATRLGEFFADRDVASV-----TASPLQRAQETAAPIARTHG 75  Kineococcu...
jgi:Caci_8083       8 VHLMRHGEVYN-------PDGilygRLPGFRLSDLGRKMAERVADHLADHDVKAV-----VASPLQRAQETAAPIAARHD 75 
jgi:Kfla_6329       7 VHLMRHGEVHN-------PTGvlygRIPDFHLSELGRKMADRVAEHVAGRDVVHL-----VSSPLERAQETMEPIARTFG 74 
CBT76682            6 VHLLRHGEVFN-------PDRmlygRIPGFGLSELGFQMADGAGEYFAKRQAEGGnvvrlVASPLVRAQQTAAPASKALG 78 
CCG05276            7 VHLLRHGEVHN-------PGGvlygRLPGYRLSDAGEQMAVRAADWFAGRDVVHL-----VSSPLERAQQTARPLAKAFG 74 
4IJ5_A             72 LEVIKEDRIIEIDHG-MWSGMl-VEEVME--KYPEDFRRWVEephkvEfqgGESLASVYNRVKGFLE-----EVRKRHWN 142 Hydrogenob...
jgi:Cyan7822_4494 104 LPIKLEAGLSEWLNP-AWMTEapQTHPKEllQLEYPRIDWRYtsrviPq-yPESEETMMRRSAETAR-----QLVTQFSE 176
tigr:GBAA_5203     67 LSIQEDERLAERILS-DVPm---DDWMQKleSTFTNIDIAFSg--------GESTKQATDRAISLIQ-----HVLKLNYT 129
WP_015736428       68 LPIAEQEDLRERMAG-DLQGH---SFLDAkkKLFQDSAFSFPg--------GESGKAAQSRAIRAFE-----IILNAYGG 130 Paenibacil...
Q8NT72             74 LELITDEDLLE-AGN-RFEGLrtKGWRSQlwNPVRWPLMYNPtl--pSw--GEHYTDILERMMAAVE-----RARVAAEG 142 Corynebact...
WP_012085042       76 LPLGTEPRIIE--AGnRFEGHrvTEGRGSirDPRVWPRLWNPvq-psW---GEPYEQQVARVSAVVR-----DARDTFPG 144 Kineococcu...
jgi:Caci_8083      76 LEIGTDERLIE-AAN-FFEGKk-FSVGDGvlKRPAVWFKLWNpfkpsW---GEPYKEQVKRMHAALL-----AAAELAPG 144
jgi:Kfla_6329      75 LTPDLDERVIE-AAN-LFEGRk-FGVGDGalKNPGTWWLLRNpvkpsW---GEPYQQIVRRMRDAIE-----TARQKAAG 143
CBT76682           79 LEIHTDERVIE--AGnKLQGLskVAEHLRkpKYWPLLVNPLKp---sW---GEPYAEQVARMRTAMAeqrkaAVAEHGEG 150
CCG05276           75 LEVATDERIIE--AGnAFEGLv-VGGGGGvfRAPRNWWRLRNpfqpsW---GEPYVEIAARMIAAVE-----AARDAARG 143
4IJ5_A            143 qtVVVVSHTVPMRAMYCAll-gVDLSKFWSFGC-DNASYSVIHMEERRNVILKLNIT 197 Hydrogenobacter thermophilus TK-6
jgi:Cyan7822_4494 177 d-ILLVGHGASVLGATWGlvegNPQIQA------SLCCLVKIVRNTHTWEMLLKGDT 226
tigr:GBAA_5203    130 t-TLLVTHGNLLTLILKYfdhtIGFHEWKAL---TNPDVYEIVIDEQCTIKRLWEAS 182
WP_015736428      131 krVAIGTHGDIMTLMLQHyderFDYHFWLGT---TLPDIYCAEFEEGRLVNLARLWS 184 Paenibacillus sp. Y412MC10
Q8NT72            143 heAILVTHQLPIVCVQRHar-gQSLSHNPATRQcDLASVTSLVFQDDQIVGVHYNEp 198 Corynebacterium glutamicum
WP_012085042      145 reSVLVSHQLPVWVTRLRaegrPLVHDPRKRQC-ALASVTSLEFSGRTLVSVAYTEP 200 Kineococcus radiotolerans
jgi:Caci_8083     145 heVVLVSHQLPIWISRLAaehrSFFHDPRKREC-TLASLTSFEITDGRITAVRYSEP 200
jgi:Kfla_6329     144 heALIVSHQLPIWTIRSAvenrRLWHDPRRRQC-SLASLTTFTFHGESIVSVGYAEP 199
CBT76682          151 aeVIIVSHQLPIWVTRRDaekkPLWHDPRQREC-TLASITSFDFEGDELVSVRYTEP 206
CCG05276          144 heAVLVSHQLPIWTTRLHvegrRFVHDPRRREC-SLASVTSLTYDGDRFVGVSYAEP 199
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