Conserved Protein Domain Family
HSD3

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pfam15244: HSD3 
Spermatogenesis-associated protein 7, or HSD3
Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterized by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).
Statistics
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PSSM-Id: 464584
Aligned: 12 rows
Threshold Bit Score: 524.749
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHH63817       9 ATSVLPRYGPPCLFKGHLSTKSN----AFCTDSSSlRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSMSTSVKYADQQ 84 
XP_003472388   9 ASPVLPRCSPPCLFKGHLSTKSN----AFCTDSSSlRLTTLQLIKNHMAVHYNKILSAKAAVDCSIPVSMSASIKYADQQ 84 
Q80VP2         9 ATSVLPRYSPPCLFTGHLSTKSN----AFCTDSSSlRLSTLQLVKNHMAIHYNKILSAKAAVDCSIPVSVNTSIKYADQQ 84  house mouse
XP_007472732  14 TNYVMPRYVPSSPFTGHLSTKSN----AFCTDSSSlRLSTLYLIKNHMAVHYNKILSAKAVVDCSMPVSMISSVKYSDQQ 89 
3_pfamImport   1 EYRAIPRYGPASPFKGHLSTKSN----AFCIDSSSrRLSNQYLIRDHMAVHYNKILSAKAAVDCSVPKSRVNSIKFSDQQ 76 
2_pfamImport   1 HTSVISFFKSASPFKGQLSTKSN----AFCIDSSR-SLTNQYLIRDHLMFHYNRILSAKAAVDCSVPRSRLNSIKLADQQ 75 
XP_004010880  23 AASVLPTFDPSCLFKGHLSTKSN----AFCTDSSSlRLSSLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQ 98 
XP_006087046   9 SSSVLPRSVPPCLFKGHLSTKSN----AFCTDSSSlRLSTLHMVKNHMAVHYNKILSAKAVVDCSVPLSIGACIKYADQQ 84 
XP_023483992   9 ATSVLLRCSPPDLFKGHLSTKSN----AFCTDSSSlRLSTLHLVKNHMAVHYNKILSAKAIVDCSVPLSMSTSIKYADQQ 84 
XP_015205573  14 NVTPVPRYSLAGPFKGHMSIKSS----PYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQ 88  spotted gar
XP_010587096   4 SRRVLPRYDPPCLLKGHLSTKSN----AFCTDSSSlRLNTLHLVKTHMAAHYNKILSAKAAVDCSVPVSISTSIKYADQQ 79  African savanna...
XP_015205572  14 NVTPVPRYSLAGPFKGHMSIKSSrksaAYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQ 92  spotted gar
EHH63817      85 RREKLKKELARCEKEFKLTKTAMRANSKNNSKSLFNTLQKPSGEPQIEdDMLKEEMNGFSSFARSLVPSSERlHLSLHKS 164
XP_003472388  85 RREKLKKELERCEKEFKLNKTSIQANSKKRLKSIFNTLQKPAGEPQNQ-GMLIEEMNGFPSFTKALLPSSET-QLRLRKS 162
Q80VP2        85 RREKLRKELARCEKEFKLSKSAMQTNSKMNSKFFVNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGlHLSLPES 163 house mouse
XP_007472732  90 RREKLKKELAQCEKELKSAKISTQTSNKFSPSPRLSPSRKLSEELPDK-DEETEEENDFPSLSKSLPPASDKqFPDFSIL 168
3_pfamImport  77 RREKLKKEVEKCEKEMISSRNGSRTSSRESRRPMSAFYRKPASGELGR-DIEEATSNNPRSRCKVILQYFSRlELGVWNA 155
2_pfamImport  76 RREKLKKKIARYEKEMSVGKNASRSSSRESGKLLSTSFGKPS----DKgGRYVDKINSFNYFTAKTTIVAAYkLSCVKKH 151
XP_004010880  99 RREKLKKELARCGRELKFTKTTVH--PKSHSKSLLNTLQKPSGEPQDEnGLLIEEVNEFPSFTQSPVISSER--LSLPKS 174
XP_006087046  85 RREKLRKEIAQCERELQGTKTTVQANSKNNSKSLLNTLQKPAEEPRNEgNMLIEEVNEYASFARSPGTSSERlHLSLPKS 164
XP_023483992  85 RREKLKKELAQCERGLKLTKTAMRANSKNNSKSL-NTLQKPSGEPHDEdGVLLKEVNGFPSFTRSRVTSSERlHLSAPKS 163
XP_015205573  89 RRERLKKKVSQCETKVISAQTGLQKTSTNNTRPSSADIVQSCASLQGNdEGDCFHYLESHLISSPRFAASCHsSQFLCQS 168 spotted gar
XP_010587096  80 RREKLKRELARCEKELRLAKTIRQANSKNNSRSILSTLQKPAGEPQDEaDVLIEGIREFPSFARSRVPSSERlLLGPCKS 159 African savanna...
XP_015205572  93 RRERLKKKVSQCETKVISAQTGLQKTSTNNTRPSSADIVQSCASLQGNdEGDCFHYLESHLISSPRFAASCHsSQFLCQS 172 spotted gar
EHH63817     165 DKVITNGPEKNSSSS-PSSVDYAASGPRK---------------------PGSGTLYGR-RPRSTFPNSHRFQLVISKAP 221
XP_003472388 163 DRVPMNGASQNGSSS-PSSVDCITSDPRN---------------------LGPGAVHGR-RPRSAFPSSHRFQVVISKAP 219
Q80VP2       164 SKMLMSGTQKHASTS----------PSRH---------------------SGCGHGCDR-RPR----SAHQFQVALAKTP 207 house mouse
XP_007472732 169 EKSFRNETRRSYSTS------GTSSPRRQ---------------------FCVSSRNAAtGSTKNTKNPRMFQLFASKAP 221
3_pfamImport 156 SQSVSSSPKKASNASlLSSSTSTSSLQRL---------------------HSKMSWSSS-SDSITNKHSQKMHNAESKAS 213
2_pfamImport 152 SRNRSNASNSNSSVS------TSSTPRKR---------------------SGVSSCCSS-DSFVSISHSQRRQESNSKIY 203
XP_004010880 175 QNVLTNCTEKNSSCS-MSSMDYAASGSKK---------------------PSSGTSYGR-GPRGTFPGSQKFQLVISKAP 231
XP_006087046 165 NDSLTGGTEKNFGSF-LSSIDCTTSRPRK---------------------THSATSNSR-RPRST--NSHRSQLVVKKTS 219
XP_023483992 164 SKVLTNSPEKNSSSS-QSSMDYTTSGPRK---------------------PCSGTVYGR-RPRSTVPNSYRFELVISKAP 220
XP_015205573 169 SRSGQKATKPFYRSSsESGFRSPFTRREH---------------------STQSYTSSS-GIFKSKISYNSFHDPNQKTY 226 spotted gar
XP_010587096 160 DKVLTSGTEENSSSS-LTSMGHTVSRPRKlssarpysrgprsagprsacpS-----------------PHRFQLVISKAP 221 African savanna...
XP_015205572 173 SRSGQKATKPFYRSSsESGFRSPFTRREH---------------------STQSYTSSS-GIFKSKISYNSFHDPNQKTY 230 spotted gar
EHH63817     222 SGDLLDKHAELFSNKQlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFADQRIEAETQTEL----------SFKSELGT 289
XP_003472388 220 SGDLLEKHADFFSNKQlPFTPRTLKTEAKSFLSQYRYYTPAKRR--KDITDPQIEGETQTELs---------SCHSDLGT 288
Q80VP2       208 SGDLLEKHSDLFSNKQsPFTPRTLKTEAKSFLSQYRYYTPAKRR--KDFSDQRMEAETQTELs---------SFNSELGT 276 house mouse
XP_007472732 222 SGDLLEKHSAHFTNQElPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFQDQLIEAETQTELs---------SFKTHFIR 290
3_pfamImport 214 SKDLLEAHSEYFTNGQqPFTPRTLKSDAKSFLSQYRYYMPARSKl-LDVFNQQVEAETQTDI----------IFSP-LGN 281
2_pfamImport 204 SGDLLDRHSELFTSSRkPFTPRTLISDAKSALLGYRYYTAAQRKr-KKHCKRHVEAETQTDVi---------SFPSADKG 273
XP_004010880 232 SGDLLDKHSEHFSNRHlPFTPRTLKTEAKSFLSQYRYYTPARRK--KNFTNRRIEAETQTELs---------SFKSDFET 300
XP_006087046 220 SGDLLDKHSKLFSNGHlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFTDQRIEAETQTELs---------SFKPDFET 288
XP_023483992 221 SGDLLDKHSELFSNRHlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDLTDQRIQAETQAGLi--------sSFKPDFET 290
XP_015205573 227 SGDLLQKHSHCFTEDK-PFTPKTLKKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDNn---------SFSDNVGS 296 spotted gar
XP_010587096 222 TGDLLDKHSELFSNKElPFTPRTLKTDAKSFLSRYRYYTPARRK--K---AQRIEAETQTEVs---------SFNSDFET 287 African savanna...
XP_015205572 231 SGDLLQKHSHCFTEDK-PFTPKTLKKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDNnsfsdnvgspQEKSi--- 306 spotted gar
EHH63817     290 AETKNVTESE--------MNIK-Q--ASNCVTYDAKEKIAPLPLQG----HDLTWDEIKDdALQHSSPRAVCQYSLK-PP 353
XP_003472388 289 SEIKKLTDSE--------VNTE-Q--ASNYMTYGTKEKLTPLSLQG----HDLTWDEIKDsAPRPSSQRTVCQYSAQ-RP 352
Q80VP2       277 AEKTSSKDSE--------VNIN-Q--VPNYTRNGAEDKIAPLPSQG----QNLAWDSIQDgILQQSSERASCKLSTE-FS 340 house mouse
XP_007472732 291 AELNNM-GSE--------VIID-EsdTSNYKIYGMKENFTPSQTLG----NSITWDKVKDdILHYPLSRASIPYYLQ-PS 355
3_pfamImport 282 AATRDFACSS--------LFSKiFlvICKNVTYTKKKNFAFCA-------------EYKSsALKHC---VVCKCSAQ-RQ 336
2_pfamImport 274 SERKVMTEQQ--------KMTV-K--AIYCVANDTESLTQKSASSS----EFFYWNRVSElLLLIFLIREASLYSEQ-LS 337
XP_004010880 301 VEIKNATDSE--------MNIR-Q--ASGCVSDGTKGRRAPLPLQG----HELLWDKMRDgALQCSSSRAVCQYSLQ-PP 364
XP_006087046 289 VETKDFTESE--------VTIK-Q--ASSCMTYGTKENITPSPSQE----KGLPWEEVKDgALQCSSARALCQYSVQpPP 353
XP_023483992 291 VETKNFKDSE--------L----Q--ASSCMTVGTQGKISPLPVEV----PGSPWDKVKDgARQCSss------------ 340
XP_015205573 297 PQEKSILPQDsftdhewsFEEH-L--IEDHLSYENLSKI---QNTG-----------MGNtDQLYSLSRI-PPERMK-SP 357 spotted gar
XP_010587096 288 AETENLTDSE--------VNIQ-Q--APSCLTHGTREK-TPLPSQK----YGLTWDEIKEgVLQRSAPRTISKYSLQ--P 349 African savanna...
XP_015205572 307 lPQDSFTDHE--------WSFE-EhlIEDHLSYENLSKIQNTGMGNtdqlYSLS---------------RIPPERMK-SP 361 spotted gar
EHH63817     354 ATSKiysdEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKH-LEEEKMRHLLHVLKVDLG 420
XP_003472388 353 WENKis-nEEELLYLSFIEDITNEILKLGLFSSRFLDRLFERHVKENKHrLKEEKMRHLLHGLKIDLG 419
Q80VP2       341 PDSKiysdEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIKKNKHhLEEGKMRYLLHGLKVDLG 408 house mouse
XP_007472732 356 PVKKiqseEEELLYLSFIEDVTDEILKLGLFSNRVLERLFERHIEKNKHhLEEKKMRHMLHVLKVDLG 423
3_pfamImport 337 AIRKiqaeEEELMYLSFIQDITDEILRLGLFSNRALEMLFERHIEQNKRhLNETKMRHLLEILKIDLG 404
2_pfamImport 338 ARMNieavEDDHLYLTFIEDVTNDILDIGLFSNRVLEQLFECHIQENKNrLDESKMRHLLDVLKEDLG 405
XP_004010880 365 SGRKmysdEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHhLEEEKMRRLLHVLKVDLG 432
XP_006087046 354 SRRKiysdEEELLYLSFIEDVTDEILKLGLFSNRSLERLFERHIRQNKHhLEEGKMRHLLHILKVNLG 421
XP_023483992 341 -------sEEELLYLSFIEDITDEILKLGLFSNRFLERLFERHIKQNKHhLEEEKMRHLLRVLKVDLG 401
XP_015205573 358 TMRKvtaeEEELRYLEFIADVTNEILTMGLYSNRVLERVFERHFEMNKHrLDNDKMRHLLDVLRHDLG 425 spotted gar
XP_010587096 350 SGRKihsdEEELLYLSFIEDITDEILKLGFFSNRFLERLFERHIKENKHhLEERKMRHLLHVLKVNLG 417 African savanna elephant
XP_015205572 362 TMRKvtaeEEELRYLEFIADVTNEILTMGLYSNRVLERVFERHFEMNKHrLDNDKMRHLLDVLRHDLG 429 spotted gar
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