6Y7F


Conserved Protein Domain Family
ELO

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pfam01151: ELO 
GNS1/SUR4 family
Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.
Statistics
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PSSM-Id: 460083
Aligned: 139 rows
Threshold Bit Score: 118.488
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Y7F_A        29 LLMSSPLPQTILLGFYVYF-VtSLGPKLME---NRKPF--El------------------kKAMITYNFFIVLFSVYMCY 84 
CAP33333      10 AVNVSFIPIHLLGILYVFIaF-NFRPSHNS---DR--------------------------SYLKEWYYFNCIFQLVLGL 59 
XP_001563354  19 YLLKNIDLVGYIASFYLVM-V-GKGDRILSwwnARKPLapNaaakqngankemvaalkscyTAASMYHLVVSIAGAAISC 96 
XP_001614732  17 LAGKYEKTILLISLLYIPA-V-LALQKVMR---RRKEI--Ea------------------kALKVAWNVCLSALSLMGVL 71 
Q9HB03        29 FFEEYWATSFPIALIYLVL-I-AVGQNYMK---ERKGF--Nl------------------qGPLILWSFCLAIFSILGAV 83  human
Q20300        18 VARGLEGFSAKLAVGYIAT-I-FGLKYYMK---DRKAF--Dl------------------sTPLNIWNGILSTFSLLGFL 72  Caenorhabditis ...
XP_002633891  23 HIAQTQWPAFWISMAYVVV-I-FGIKAAMV---NRKPF--Dl------------------tGPLNYWNAALAIFSTAGSV 77 
XP_002633947  61 FIHEHFGLFVQMTIAYVIV-I-FSIKRCMR---DREPF--Kl------------------tNALRFWNFFLSVFSIYGSW 115
XP_002633945  39 FFADHFDVTIQASILYMVV-V-FGTKWFMR---NRQPF--Ql------------------tVPLNIWNFILAAFSIAGAI 93 
XP_002632413  27 YMSTFVPLSYKIMVGYLIT-I-YFGQKLMA---HRKPF--Dl------------------qNTLALWNFGFSLFSGIAAY 81 
6Y7F_A        85 EFVmsGWGIGY--S--FRCDiVD-YSRSPTA--LRMaRtCWLYYFSKFIELLDTIFFVLR-----------K--KnsQVT 144
CAP33333      60 LMIpeILISLFs-G--WHYSvCQ-AGSLYTG--FLSgTvVFIWTITKIVDLFETLLLLYD-----------A--R--RPL 118
XP_001563354  97 MLVpaMAQSLL--AnsFFEVmCLwDDTRIYK--GYVaFaLSAAVMVKVVEQLDTFFLILRdyivaspaqkeKqvR--RVQ 170
XP_001614732  72 LILiyDPHVLK--SiiLEETeYR----------PETrAvISIFTLTKVVEYGDTVFLILK-----------K--K--KLT 124
Q9HB03        84 RMWgiMGTVLLtgG--LKQTvCF--INFIDN--STVkFwSWVFLLSKVIELGDTAFIILR-----------K--R--PLI 142 human
Q20300        73 FTFptLLSVIRkdG--FSHTySH-VSELYTD--STSgYwIFLWVISKIPELLDTVFIVLR-----------K--R--PLI 132 Caenorhabditis ...
XP_002633891  78 FTSfgLLHEFVtrG--FFESyIH--IGDFYN--GFSgFfTWLFVLSKVAEFGDTLFIVLR-----------K--K--PLM 136
XP_002633947 116 AMFpfMVEQIRrfG--LYGCgCE----ALSTlpSQAeYwLFLTVLSKALEFVDTFFLVLR-----------K--K--PLI 174
XP_002633945  94 KMTpeFFGTIAnkG--LVASyCK--VFDFTK--GENgYwVWLFMASKLFELVDTVFLVLR-----------K--R--PLM 152
XP_002632413  82 KLIpeLVSVFMkdG--FVASyCQ-NETYYTD--PSTgFwGWAFVMSKAPELGDTMFLVLR-----------K--K--PVI 141
6Y7F_A       145 FLHVFHHTIMPWTWWFGVKFAAgGLGTFHALLNTAVHVVMYSYYGL--SALgpayQKYL--WWKKYLTSL--QLVQFVIV 218
CAP33333     119 TIHIIHHFLSLSYAFTFYSQNFaIHRWI-VFFNLTAHVFLYAYLSG---------YKILnrWTPCWVAVCssQMLQLILP 188
XP_001563354 171 PSHWWFQGLIALYFWHTYSIGT-SCFTMIATLTMVMSAARNFVYMQqdTAQah-gKSAAavKLNSAIVAL--DMMEWIGC 246
XP_001614732 125 FLHSYHHLSVVIYCLYSQKELV-SHAHYFVFLNLVVHAIMYFYFGF--IYI----VPKIlyKVRQFITCL--QILQMFIG 195
Q9HB03       143 FIHWYHHSTVLVYTSFGYKNKVpAGGWFVT-MNFGVHAIMYTYYTL--KAA----NVKPpkMLPMLITSL--QILQMFVG 213 human
Q20300       133 FMHWYHHALTGYYALVCYHEDAvHMVWV-VWMNYIIHAFMYGYYLL--KSL----KVPIppSVAQAITTS--QMVQFAVA 203 Caenorhabditis ...
XP_002633891 137 FLHWYHHVLTMNYAFMSFEANLgFNTWI-TWMNFSVHSIMYGYYML--RSF----GVKVpaWIARNITTM--QILQFVIT 207
XP_002633947 175 FLHWYHHVATFLFFCVTYPTPS-SQIRVGAIVNLFVHAFMYPYYFI--RSM----NIKLpaKISMAVTVL--QLTQFVCF 245
XP_002633945 153 FLHWYHHILTMIYAWYSHPLTP-GFNRYGIYLNFVVHAFMYSYYFL--RSM----KIRVpgVIAQAITSL--QILQFIIS 223
XP_002632413 142 FMHWYHHALTFVYAVVTYSEHQaWARWSLA-LNLAVHTIMYFYFAV--RAL----NIQTprPVAKFITTI--QIVQFVIS 212
6Y7F_A       219 AIHIsq----fFFME--DCKY--QfPVFACIIMSYSFMFLLLFLHFWYR---AY----TKGQRLPK 269
CAP33333     189 FIATlfaaakmTRGT--QCDA--N-ALGIFTLQIGLSVMILLFADFYWSrlqEF----RRKNMKKL 245
XP_001563354 247 SALSvyaslmnYTDKr-GCMT--M-QANVRMALVMYVTAVVLRLRELIK---GAeglaARESKKHQ 305
XP_001614732 196 IFIs------yYAIR--NVENqiY-VKNAIASFALYLTYAILFLNFYFN---NY----CKNVKSNV 245
Q9HB03       214 AIVsilt-yiwRQDQ--GCHT--T-MEHLFWSFILYMTYFILFAHFFCQ---TY----IRPKVKAK 266 human
Q20300       204 IFAQvhvsykhYVEGveGLAY--S-FRGTAIGFFMLTTYFYLWIQFYKE---HY----L-KNGGKK 258 Caenorhabditis elegans
XP_002633891 208 HFILfhvgylaMTGQ--SVDS--T-TGYYWFCLLMEISYVVLFGNFYYQ---SY----IKGGGKKF 261
XP_002633947 246 IYGCtlmyyslATNQy-TCDT--P-MFALNSTFGLSLSYFVLFANFFHK---SY----LQRGGKEK 300
XP_002633945 224 CAVLahlgylmHFTNa-NCDF--D-PSVFKLAVFMDTTYLALFINFFLQ---SY----VLRGGKDK 278
XP_002632413 213 CYIFghlvfikSANSvpGCAV--S-WNVLSIGGLMYISYLFLFAKFFYK---AY----IQKRSPTK 268
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